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Literature summary for 4.4.1.20 extracted from

  • Nicholson, D.W.; Ali, A.; Klemba, M.W.; Munday, N.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.
    Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells (1992), J. Biol. Chem., 267, 17849-17857.
    View publication on PubMed
Search for more literature for 4.4.1.20

Inhibitors

Inhibitors Comment Organism Structure
diethylcarbamazine IC50: 0.05 mM Homo sapiens
NEM IC50: 0.02 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0056
-
 leukotriene A4 pH 7.4, 25°C Homo sapiens
1.2
-
 glutathione pH 7.4, 25°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
membrane
-
 Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell monocytic leukemia cell line Homo sapiens
-
U-937 cell dimethyl sulfoxide-differentiated and undifferentiated Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000399
-
 differentiated cells Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4 + H2O
-
 ?
leukotriene A4 + glutathione
-
 Rattus norvegicus leukotriene C4 + H2O
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.02
-
 IC50: 0.02 mM Homo sapiens NEM
0.05
-
 IC50: 0.05 mM Homo sapiens diethylcarbamazine