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4.4.1.20: leukotriene-C4 synthase

This is an abbreviated version!
For detailed information about leukotriene-C4 synthase, go to the full flat file.

Word Map on EC 4.4.1.20

Reaction

leukotriene C4
=
leukotriene A4
 +
glutathione

Synonyms

(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening), EC 2.5.1.37, leukotriene A4:glutathione S-leukotrienyltransferase, leukotriene C4 synthase, leukotriene C4 synthetase, LT C4 synthase, LTC4 synthase, LTC4 synthetase, LTC4S, LTCS, synthase, leukotriene C4

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.20 leukotriene-C4 synthase

Specific Activity

Specific Activity on EC 4.4.1.20 - leukotriene-C4 synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000399
-
differentiated cells
0.00786
-
-
0.044
mutant R104K, 22°C, pH not specified in the publication
0.0562
with leukotriene A4 free acid as substrate
0.0813
with leukotriene A4 methyl ester as substrate
0.29
-
crude enzyme from homogenate, at 25°C
0.4
mutant R104T, 22°C, pH not specified in the publication
0.729
-
-
1.6
mutant R104S, 22°C, pH not specified in the publication
1.74
-
-
10
mutant R51Q, 22°C, pH not specified in the publication
10.5
mutant R31Q, 22°C, pH not specified in the publication
2
mutant R104A, 22°C, pH not specified in the publication
20
mutant R51A, 22°C, pH not specified in the publication
28
-
recombinant enzyme, after 97fold purification, at 25°C
30.5
-
-
35
wild-type, 22°C, pH not specified in the publication
4.135
-
-
4.3
mutant R31A, 22°C, pH not specified in the publication