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4.4.1.20: leukotriene-C4 synthase

This is an abbreviated version!
For detailed information about leukotriene-C4 synthase, go to the full flat file.

Word Map on EC 4.4.1.20

Reaction

leukotriene C4
=
leukotriene A4
 +
glutathione

Synonyms

(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening), EC 2.5.1.37, leukotriene A4:glutathione S-leukotrienyltransferase, leukotriene C4 synthase, leukotriene C4 synthetase, LT C4 synthase, LTC4 synthase, LTC4 synthetase, LTC4S, LTCS, synthase, leukotriene C4

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.20 leukotriene-C4 synthase

Expression

Expression on EC 4.4.1.20 - leukotriene-C4 synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression in mast cells is not apparent in healthy subjects
hepatic mRNA expression of LTC4S is decreased in presence of NO donor O2-vinyl-1-(pyrrolidin-1-yl)-diazen-1-ium-1,2-diolate, i.e. V-PYRRO/NO. Downregulation may occur via inhibiting NF-kappaB activation independent of IkappaBalpha during hepatic ischemia/reperfusion injury
G3V6E6
is not suppressed by pretreatment with the p38 inhibitor
LTC4s increases following spared nerve injury, significant increase 3 days after nerve injury and continues at least for 14 days. LTC4s mRNA is expressed constitutively throughout the grey matter and increases after nerve injury in dorsal horn. This increase in LTC4s mRNA mainly occurrs in cells with small nuclei
mRNA levels for the three key enzymes/proteins in the biosynthesis of cysteinyl-leukotrienes, 5-lipoxygenase, 5-LO-activating protein, and LTC4 synthase, are significantly increased in the wall of human abdominal aortic aneurysm
-
no upregulation by interleukin-4 in the THP-1 cell line
significantly elevated immunoexpression of LTC4 synthase observed in perennial allergic rhinitis biopsies