4.4.1.20: leukotriene-C4 synthase
This is an abbreviated version!
For detailed information about leukotriene-C4 synthase, go to the full flat file.
Word Map on EC 4.4.1.20
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4.4.1.20
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asthma
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lta4
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cysteinyl
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5-lipoxygenase
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arachidonic
-
eosinophil
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asthmatic
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flap
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bronchial
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eicosanoids
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aspirin
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cysteinyl-leukotrienes
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cys-lts
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cysltr1
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aspirin-induced
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bronchoconstriction
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5-lipoxygenase-activating
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aspirin-intolerant
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alox5ap
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montelukast
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1-chloro-2,4-dinitrobenzene
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mapeg
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aspirin-exacerbated
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rbl-1
-
medicine
-
bronchoconstrictors
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a23187-stimulated
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molecular biology
-
drug development
-
analysis
- 4.4.1.20
- asthma
- lta4
-
cysteinyl
-
5-lipoxygenase
-
arachidonic
-
eosinophil
-
asthmatic
- flap
- bronchial
-
eicosanoids
- aspirin
- cysteinyl-leukotrienes
-
cys-lts
-
cysltr1
-
aspirin-induced
-
bronchoconstriction
-
5-lipoxygenase-activating
-
aspirin-intolerant
-
alox5ap
- montelukast
- 1-chloro-2,4-dinitrobenzene
-
mapeg
-
aspirin-exacerbated
- rbl-1
- medicine
-
bronchoconstrictors
-
a23187-stimulated
- molecular biology
- drug development
- analysis
Reaction
Synonyms
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening), EC 2.5.1.37, leukotriene A4:glutathione S-leukotrienyltransferase, leukotriene C4 synthase, leukotriene C4 synthetase, LT C4 synthase, LTC4 synthase, LTC4 synthetase, LTC4S, LTCS, synthase, leukotriene C4
ECTree
4.4.1.20 leukotriene-C4 synthaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.4.1.20 - leukotriene-C4 synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
leukotriene A4 methylester + glutathione
leukotriene C4 methylester
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pH 7.4, 37°C
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-
r
leukotriene A4 + glutathione
leukotriene C4
glutathione-enzyme binding structure, overview
i.e. (5S)-hydroxy-(6R)-S-glutathionyl-7,9-trans-11,14-cis-eicosatetraenoic acid
-
?
leukotriene A4 + glutathione
leukotriene C4
-
mechanism of leukotriene A4 binding, docking and molecular dynamics simulations using the enzyme crystal structure, PDB ID 2PNO, overview
-
-
?
leukotriene A4 + glutathione
leukotriene C4
glutathione-enzyme binding structure, overview
i.e. (5S)-hydroxy-(6R)-S-glutathionyl-7,9-trans-11,14-cis-eicosatetraenoic acid
-
?
leukotriene A4 + glutathione
leukotriene C4
free acid, 4°C, pH 7.35
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-
r
leukotriene A4 + glutathione
leukotriene C4
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pH 7.4, room temperature
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-
r
leukotriene A4 methyl ester + glutathione
leukotriene C4 methyl ester
-
-
-
-
?
leukotriene A4 methyl ester + glutathione
leukotriene C4 methyl ester
-
-
-
?
leukotriene A4 methyl ester + glutathione
leukotriene C4 methyl ester
4°C, pH 7.35
-
-
r
leukotriene A4 methyl ester + glutathione
leukotriene C4 methyl ester + H2O
-
-
-
-
?
leukotriene A4 methyl ester + glutathione
leukotriene C4 methyl ester + H2O
-
-
-
-
?
leukotriene A4 methyl ester + glutathione
leukotriene C4 methyl ester + H2O
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6.5% of the activity with leukotriene A4
-
-
?
leukotriene A4 methyl ester + glutathione
leukotriene C4 methyl ester + H2O
-
-
-
-
?
leukotriene A4 methyl ester + glutathione
leukotriene C4 methyl ester + H2O
-
-
-
-
?
additional information
?
-
binding structure of product analogue S-hexyl GSH to the active site of the enzyme, overview
-
-
?
additional information
?
-
-
binding structure of product analogue S-hexyl GSH to the active site of the enzyme, overview
-
-
?
