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Literature summary for 4.4.1.20 extracted from
- Leukotriene C4 synthase: characterization in mouse mastocytoma cells (1990), Methods Enzymol., 187, 306-312.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| indomethacin | poor inhibitor | Mus musculus |  |
| Rose bengal | IC50: 0.05 mM | Mus musculus | |
| Triphenyltin chloride | poor inhibitor | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mastocytoma cell | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 30.5 | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + glutathione | - |
Mus musculus | leukotriene C4 + H2O | - |
? | |
| leukotriene A4 methyl ester + glutathione | - |
Mus musculus | leukotriene C4 methyl ester + H2O | - |
? | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
IC50: 0.05 mM | Mus musculus | Rose bengal | |
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