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4.4.1.20: leukotriene-C4 synthase

This is an abbreviated version!
For detailed information about leukotriene-C4 synthase, go to the full flat file.

Word Map on EC 4.4.1.20

Reaction

leukotriene C4
=
leukotriene A4
+
glutathione

Synonyms

(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening), EC 2.5.1.37, leukotriene A4:glutathione S-leukotrienyltransferase, leukotriene C4 synthase, leukotriene C4 synthetase, LT C4 synthase, LTC4 synthase, LTC4 synthetase, LTC4S, LTCS, synthase, leukotriene C4

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.20 leukotriene-C4 synthase

KI Value

KI Value on EC 4.4.1.20 - leukotriene-C4 synthase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000037
2-benzoyl-5-(5-[(4-chlorophenyl)(methyl)amino]pyridine-2-carbonyl)benzoic acid
pH 7.8, temperature not specified in the publication, recombinant enzyme
0.01
2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione
IC50 value
0.0023
leukotriene A4
-
pH 7.4, 25°C
0.00036
leukotriene C2
-
-