4.4.1.1: cystathionine gamma-lyase

This is an abbreviated version!
For detailed information about cystathionine gamma-lyase, go to the full flat file.

Reaction

Synonyms

AFUA_8G04340, C-S-lyase, C-S-lyase1, C-S-lyase2, C-S-lyase3, C-S-lyase4, cgl, CGL like protein, CS-LIKE, CSE, CSEgamma, CTH, CTT, cystalysin, cystathionase, cystathioninase, cystathionine beta/gamma-lyase, cystathionine gamma lyase, cystathionine gamma-lyase, cystathionine gamma-lyase-like protein, cystathionine-gamma-lyase, cysteine desulfhydrase, cysteine lyase, cystine desulfhydrase, dehydratase, homoserine, DES1, desulfhydrase, cysteine, EC 4.2.1.15, gamma-CTL, gamma-CTLase, gamma-cystathionase, hCSE, homoserine deaminase, homoserine deaminase-cystathionase, homoserine dehydratase, human cystathionine-gamma-lyase, L-Cys desulfhydrase, L-cysteine desulfhydrase, L-cysteine desulphydrase, L-cysteine-desulfhydrase, LCD, lyase, cystathionine gamma-, PRB-RA, Probasin-related antigen, TGME49_112930, XometC, yCGL

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.1 cystathionine gamma-lyase

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Results	in table
12	Activating Compound
5091	AA Sequence
33	Application
1	CAS Registry Number
38	Cloned(Commentary)
81	Cofactor
7	Crystallization (Commentary)
319	Disease/ Diagnostics
34	Expression
28	General Information
2	General Stability
14	IC50 Value
183	Inhibitors
50	kcat/KM [mM/s]
1	Ki Value [mM]
112	KM Value [mM]
12	Localization
4	Metals/Ions
47	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
382	Organism
11	Pathway
100	PDB ID
22	pH Optimum
8	pH Range
1	pI Value
1	Posttranslational Modification
74	Protein Variants
27	Purification (Commentary)
7	Reaction
9	Reaction Type
209	Reference
238	Source Tissue
16	Specific Activity [micromol/min/mg]
6	Storage Stability
331	Substrates and Products (Substrate)
31	Subunits
205	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
2	Temperature Range [°C]
19	Temperature Stability [°C]
61	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 4.4.1.1 - cystathionine gamma-lyase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

L-cystathione + H2O

L-cysteine + NH3 + 2-oxobutanoate

5 entries

L-cystathionine + H2O

2-oxobutyrate + L-cysteine + NH3

Rattus norvegicus

-

-

721432

-

-

?

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

10 entries

L-cystathionine + H2O

L-homocysteine + pyruvate + NH3

9 entries

L-cysteine + H2O

H2S + pyruvate + NH3

6 entries

L-cysteine + H2O

sulfide + NH3 + pyruvate

2 entries

L-cystine + H2O

pyruvate + NH3 + L-thiocysteine

Rattus norvegicus

-

-

721432

-

-

?

L-homoserine

2-oxobutyrate + NH3

Rattus norvegicus

-

the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term

721432

-

-

?

L-homoserine + H2O

2-oxobutanoate + NH3 + H2O

Lacticaseibacillus casei

B3TNN8; B3TNN9

-

708517

-

-

?

additional information

?

-

10 entries

L-cystathione + H2O

L-cysteine + NH3 + 2-oxobutanoate

Geotrichum candidum

-

-

674055

-

-

?

L-cystathione + H2O

L-cysteine + NH3 + 2-oxobutanoate

Lactococcus lactis

-

-

674055

-

-

?

L-cystathione + H2O

L-cysteine + NH3 + 2-oxobutanoate

Limosilactobacillus fermentum

-

-

674055

-

-

?

L-cystathione + H2O

L-cysteine + NH3 + 2-oxobutanoate

Limosilactobacillus reuteri

-

-

674055

-

-

?

L-cystathione + H2O

L-cysteine + NH3 + 2-oxobutanoate

Saccharomyces cerevisiae

-

-

674055

-

-

?

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

Cerebratulus marginatus

-

-

730944

-

-

r

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

Escherichia coli

-

-

729511

-

-

?

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

Homo sapiens

-

-

730038

-

-

r

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

Leishmania major

E9AFE7

-

730121

-

-

r

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

Leishmania mexicana

-

-

730121

-

-

r

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

Neurospora crassa

Q96VU7

-

729507

-

-

?

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

Neurospora crassa 74OR23-1a

Q96VU7

-

729507

-

-

?

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

Rattus norvegicus

-

-

730038

-

-

r

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

Rattus norvegicus Sprague-Dawley

-

-

730038

-

-

r

L-cystathionine + H2O

L-cysteine + 2-oxobutanoate + NH3

Saccharomyces cerevisiae

-

-

729315

-

-

r

L-cystathionine + H2O

L-homocysteine + pyruvate + NH3

Geotrichum candidum

-

-

674055

-

-

?

L-cystathionine + H2O

L-homocysteine + pyruvate + NH3

Homo sapiens

-

-

710078

-

-

?

L-cystathionine + H2O

L-homocysteine + pyruvate + NH3

Lacticaseibacillus casei

B3TNN8; B3TNN9

-

708517

-

-

?

L-cystathionine + H2O

L-homocysteine + pyruvate + NH3

Lactococcus lactis

-

-

674055

-

-

?

L-cystathionine + H2O

L-homocysteine + pyruvate + NH3

Limosilactobacillus fermentum

-

-

674055

-

-

?

L-cystathionine + H2O

L-homocysteine + pyruvate + NH3

Limosilactobacillus reuteri

-

-

674055

-

-

?

L-cystathionine + H2O

L-homocysteine + pyruvate + NH3

Mus musculus

-

-

672489, 707177, 710078

-

-

?

L-cystathionine + H2O

L-homocysteine + pyruvate + NH3

Rattus norvegicus

-

-

672489, 709213, 710078

-

-

?

L-cystathionine + H2O

L-homocysteine + pyruvate + NH3

Saccharomyces cerevisiae

-

-

674055

-

-

?

L-cysteine + H2O

H2S + pyruvate + NH3

Cerebratulus marginatus

-

-

730944

-

-

?

L-cysteine + H2O

H2S + pyruvate + NH3

Escherichia coli

-

-

729511

-

-

?

L-cysteine + H2O

H2S + pyruvate + NH3

Homo sapiens

-

-

730038

-

-

?

L-cysteine + H2O

H2S + pyruvate + NH3

Rattus norvegicus

-

-

730038

-

-

?

L-cysteine + H2O

H2S + pyruvate + NH3

Rattus norvegicus Sprague-Dawley

-

-

730038

-

-

?

L-cysteine + H2O

H2S + pyruvate + NH3

Saccharomyces cerevisiae

-

-

729315

-

-

?

L-cysteine + H2O

sulfide + NH3 + pyruvate

Lacticaseibacillus casei

B3TNN8; B3TNN9

-

708517

-

-

?

L-cysteine + H2O

sulfide + NH3 + pyruvate

Rattus norvegicus

-

-

708411

-

-

?

additional information

?

-

Acremonium chrysogenum

-

enzyme activity is required for high-level cephalosporin biosynthesis but not for low-level production of the antibiotic

651676

-

651676

?

additional information

?

-

Acremonium chrysogenum C10 / ATCC 48272

-

enzyme activity is required for high-level cephalosporin biosynthesis but not for low-level production of the antibiotic

651676

-

651676

?

additional information

?

-

Cereibacter sphaeroides

-

cysteine desulfhydrase in Rhodobacter sphaeroides can produce sulfide under aerobic conditions and precipitate metal sulfide complexes on the cell wall

691353

-

-

?

additional information

?

-

Homo sapiens

-

hydrogen sulfide is a gas signalling molecule which is produced endogenously from L-cysteine

695079

-

-

?

additional information

?

-

Limosilactobacillus fermentum

-

enzyme responsible for amino acid catabolism

34506

-

-

?

additional information

?

-

Limosilactobacillus fermentum DT41

-

enzyme responsible for amino acid catabolism

34506

-

-

?

additional information

?

-

Rattus norvegicus

-

hydrogen sulfide is a gas signalling molecule which is produced endogenously from L-cysteine

695079

-

-

?

additional information

?

-

Rhodopseudomonas palustris

-

responsible for the formation of nanocrystals

691890

-

-

?

additional information

?

-

Xanthomonas oryzae pv. oryzae

Q5H4T8

catalyzes the second step in the reverse-transsulfuration pathway, which is essential for the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine

690270

-

-

?

additional information

?

-

Xanthomonas oryzae pv. oryzae

-

catalyzes the second step in the reverse-transsulfuration pathway, which is essential for the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine

690270

-

-

?