Reference on EC 4.4.1.1 - cystathionine gamma-lyase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Braunstein, A.E.; Goryachenkova, E.V.
The beta-replacement-specific pyridoxal-P-dependent lyases
Adv. Enzymol. Relat. Areas Mol. Biol.
56
1-89
1984
Rattus norvegicus
Nagasawa, T.; Kanzaki, H.; Yamada, H.
Cystathionine gamma-lyase from Streptomyces phaeochromogenes
Methods Enzymol.
143
486-492
1987
Streptomyces phaeochromogenes
Stipanuk, M.H.; Beck, P.W.
Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat
Biochem. J.
206
267-277
1982
Rattus norvegicus
Flavin, M.; Slaughter, C.
gamma-Cystathionase (Neurospora)
Methods Enzymol.
17B
433-439
1971
Klebsiella aerogenes, Neurospora sp., Neurospora sp. ATCC -10816
-
Towatari, T.; Tanaka, K.; Yoshikawa, D.; Katunuma, N.
Purification and properties of a new cathepsin from rat liver
J. Biochem.
84
659-671
1978
Rattus norvegicus
Kanzaki, H.; Nagasawa, T.; Yamada, H.
Insight into the active site of Streptomyces cystathionine gamma-lyase based on the results of studies on its substrate specificity
Biochim. Biophys. Acta
913
45-50
1987
Streptomyces phaeochromogenes, Rattus norvegicus
Fearon, C.W.; Rodkey, J.A.; Abeles, R.H.
Identification of the active-site residue of gamma-cystathionase labeled by the suicide inactivator beta, beta, beta-trifluoroalanine
Biochemistry
21
3790-3794
1982
Rattus norvegicus
Alston, T.A.; Maramatsu, H.; Ueda, T.; Bright, H.J.
Inactivation of gamma-cystathionase by gamma-fluorinated amino acids
FEBS Lett.
128
293-297
1981
Rattus norvegicus
Silverman, R.B.; Abeles, R.H.
Mechanism of inactivation of gamma-cystathionase by beta,beta,beta-trifluoroalanine
Biochemistry
16
5515-5520
1977
Rattus norvegicus
Silverman, R.B.; Abeles, R.H.
Inactivation of pyridoxal phosphate dependent enzymes by mono- and polyhaloalanines
Biochemistry
15
4718-4723
1976
Rattus norvegicus
Beeler, T.; Churchich, J.E.
Reactivity of the phosphopyridoxal groups of cystathionase
J. Biol. Chem.
251
5267-5271
1976
Rattus norvegicus
Brown, F.C.; DeFoor, M.C.
Gamma-cystathionase of rat liver. The role of sulfhydryl groups in the catalytic function
Eur. J. Biochem.
46
317-322
1974
Rattus norvegicus
Brown, F.C.
gamma-Cystathionase of rat liver: effects of pyridoxal phosphate and other compounds on reaction rates
Arch. Biochem. Biophys.
171
378-384
1975
Rattus norvegicus
Heinonen, K.
Studies on cystathionase activity in rat liver and brain during development. Effects of hormones and amino acids in vivo
Biochem. J.
136
1011-1015
1973
Rattus norvegicus
Churchich, J.E.; Dupourque, D.
Dissociation of cystathionase
Biochem. Biophys. Res. Commun.
46
524-530
1972
Rattus norvegicus
Flavin, M.; Segal, A.
Purification and properties of the cystathionine gamma-cleavage enzyme of Neurospora
J. Biol. Chem.
239
2220-2227
1964
Neurospora sp.
Matsuo, Y.; Greenberg, D.M.
A crystalline enzyme that cleaves homoserine and cystathionine
J. Biol. Chem.
234
507-515
1958
Rattus norvegicus
Matsuo, Y.; Greenberg, D.M.
A crystalline enzyme that cleaves homoserine and cystathionine
J. Biol. Chem.
234
516-519
1958
Rattus norvegicus
Bikel, I.; Pavlatos, T.N.; Livingston, D.M.
Purification and subunit structure of mouse liver cystathionase
Arch. Biochem. Biophys.
186
168-174
1978
Mus musculus
Rennenberg, H.
Cysteine desulfhydrase activity in cucurbit plants: stimulation by preincubation with L- or D-cysteine
Phytochemistry
22
1557-1560
1983
Cucumis sativus, Cucurbita pepo
-
Yamada, H.; Kanzaki, H.; Nagasawa, T.
Synthesis of L-cystathionine by the gamma-replacement reaction of cystathionine gamma-lyase from Streptomyces phaeochromogenes
J. Biotechnol.
1
205-217
1984
Streptomyces phaeochromogenes
-
Kanzaki, H.; Kobayashi, M.; Nagasawa, T.; Yamada, H.
Synthesis of S-substituted L-homocysteine derivatives by cystathionine gamma-lyase of Streptomyces phaeochromogenes
Agric. Biol. Chem.
50
391-397
1986
Streptomyces phaeochromogenes
-
Smacchi, E.; Gobbetti, M.
Purification and characterization of cystathionine gamma-lyase from Lactobacillus fermentum DT41
FEMS Microbiol. Lett.
166
197-202
1998
Limosilactobacillus fermentum, Limosilactobacillus fermentum DT41
Chu, L.; Ebersole, J.L.; Kurzban, G.P.; Holt, S.C.
Cystalysin, a 46-kDa L-cysteine desulfhydrase from Treponema denticola: biochemical and biophysical characterization
Clin. Infect. Dis.
28
442-450
1999
Treponema denticola, Treponema denticola LC-67
Steegborn, C.; Clausen, T.; Sondermann, P.; Jacob, U.; Worbs, M.; Marinkovic, S.; Huber, R.; Wahl, M.C.
Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration
J. Biol. Chem.
274
12675-12684
1999
Homo sapiens
Bruinenberg, P.G.; de Roo, G.; Limsowtin, G.K.Y.
Purification and characterization of cystathionine gamma-lyase from Lactococcus lactis subsp. cremonis SK11: possible role in flavor compound formation during cheese maturation
Appl. Environ. Microbiol.
63
561-566
1997
Lactococcus lactis
Yamagata, S.; D'Andrea, R.J.; Fujisaki, S.; Isaji, M.; Nakamura, K.
Cloning and bacterial expression of the CYS3 gene encoding cystathionine gamma-lyase of Saccharomyces cerevisiae and the physicochemical and enzymatic properties of the protein
J. Bacteriol.
175
4800-4808
1993
Saccharomyces cerevisiae
Nagasawa, T.; Kanzaki, H.; Yamada, H.
Cystathionine gamma-lyase of Streptomyces phaeochromogenes. The occurrence of cystathionine gamma-lyase in filamentous bacteria and its purification and characterization
J. Biol. Chem.
259
10393-10403
1984
Amycolatopsis lactamdurans, Gordonia rubripertincta, Micromonospora chalcea, Micromonospora coerulea, Mycolicibacterium phlei, Mycolicibacterium smegmatis, Nocardia asteroides, Nocardia erythropolis, Nocardia globerula, Nonomuraea angiospora, Streptomyces lydicus, Streptomyces microflavus, Streptomyces netropsis, Streptomyces olivochromogenes, Streptomyces phaeochromogenes, Streptomyces rimosus, Streptomyces virginiae, Streptosporangium roseum
Yoshida, Y.; Negishi, M.; Amano, A.; Oho, T.; Nakano, Y.
Differences in the betaC-S lyase activities of viridans group streptococci
Biochem. Biophys. Res. Commun.
300
55-60
2002
Streptococcus gordonii, Streptococcus mutans, Streptococcus oralis, Streptococcus salivarius, Streptococcus sobrinus, Streptococcus anginosus
Levonen, A.L.; Lapatto, R.; Saksela, M.; Raivio, K.O.
Human cystathionine gamma-lyase: developmental and in vitro expression of two isoforms
Biochem. J.
347
291-295
2000
Homo sapiens (P32929), Homo sapiens
Messerschmidt, A.; Worbs, M.; Steegborn, C.; Wahl, M.C.; Huber, R.; Laber, B.; Clausen, T.
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison
Biol. Chem.
384
373-386
2003
Saccharomyces cerevisiae
Yamagata, S.; Isaji, M.; Yamane, T.; Iwama, T.
Substrate inhibition of L-cysteine alpha,beta-elimination reaction catalyzed by L-cystathionine gamma-lyase of Saccharomyces cerevisiae
Biosci. Biotechnol. Biochem.
66
2706-2709
2002
Saccharomyces cerevisiae
Dobric, N.; Limsowtin, G.K.; Hillier, A.J.; Dudman, N.P.; Davidson, B.E.
Identification and characterization of a cystathionine beta/gamma-lyase from Lactococcus lactis ssp. cremoris MG1363
FEMS Microbiol. Lett.
182
249-254
2000
Lactococcus lactis (A2RM21), Lactococcus lactis
Wang, J.; Hegele, R.A.
Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)
Hum. Genet.
112
404-408
2003
Homo sapiens
Liu, G.; Casqueiro, J.; Banuelos, O.; Cardoza, R.E.; Gutierrez, S.; Martin, J.F.
Targeted inactivation of the mecB gene, encoding cystathionine-gamma-lyase, shows that the reverse transsulfuration pathway is required for high-level cephalosporin biosynthesis in Acremonium chrysogenum C10 but not for methionine induction of the cephalosporin genes
J. Bacteriol.
183
1765-1772
2001
Acremonium chrysogenum, Acremonium chrysogenum C10 / ATCC 48272
Yamagata, S.; Yasugahira, T.; Okuda, Y.; Iwama, T.
Conversion of the aminocrotonate intermediate limits the rate of gamma-elimination reaction catalyzed by L-cystathionine gamma-lyase of the yeast Saccharomyces cerevisiae
J. Biochem.
134
607-613
2003
Saccharomyces cerevisiae
De Angelis, M.; Curtin, A.C.; McSweeney, P.L.; Faccia, M.; Gobbetti, M.
Lactobacillus reuteri DSM 20016: purification and characterization of a cystathionine gamma-lyase and use as adjunct starter in cheesemaking
J. Dairy Res.
69
255-267
2002
Limosilactobacillus reuteri
Barber, T.; Triguero, A.; Martinez-Lopez, I.; Torres, L.; Garcia, C.; Miralles, V.J.; Vina, J.R.
Elevated expression of liver gamma-cystathionase is required for the maintenance of lactation in rats
J. Nutr.
129
928-933
1999
Rattus norvegicus
Yoshida, Y.; Nakano, Y.; Amano, A.; Yoshimura, M.; Fukamachi, H.; Oho, T.; Koga, T.
lcd from Streptococcus anginosus encodes a C-S lyase with alpha,beta-elimination activity that degrades L-cysteine
Microbiology
148
3961-3970
2002
Streptococcus anginosus
Yamagata, S.; Akamatsu, T.; Iwama, T.
Immobilization of Saccharomyces cerevisiae cystathionine gamma-lyase and application of the product to cystathionine synthesis
Appl. Environ. Microbiol.
70
3766-3768
2004
Saccharomyces cerevisiae
Ishii, I.; Akahoshi, N.; Yu, X.N.; Kobayashi, Y.; Namekata, K.; Komaki, G.; Kimura, H.
Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression
Biochem. J.
381
113-123
2004
Mus musculus (Q8VCN5), Mus musculus
Cellini, B.; Bertoldi, M.; Montioli, R.; Borri Voltattorni, C.
Probing the role of Tyr 64 of Treponema denticola cystalysin by site-directed mutagenesis and kinetic studies
Biochemistry
44
13970-13980
2005
Treponema denticola
Okuno, T.; Motobayashi, S.; Ueno, H.; Nakamuro, K.
Identification of mouse selenomethionine alpha,gamma-elimination enzyme: cystathionine gamma-lyase catalyzes its reaction to generate methylselenol
Biol. Trace Elem. Res.
108
245-257
2005
Mus musculus
Okuno, T.; Ueno, H.; Nakamuro, K.
Cystathionine gamma-lyase contributes to selenomethionine detoxification and cytosolic glutathione peroxidase biosynthesis in mouse liver
Biol. Trace Elem. Res.
109
155-171
2006
Mus musculus
Goto, T.; Osada, Y.; Funatsu, H.; Sugiyama, H.; Takagi, S.; Mochizuki, A.
Characterization of cystathionine g-lyase in the liver of rainbow trout Oncorhynchus mykiss
Fish. Sci.
71
245-247
2005
Oncorhynchus mykiss
-
Cellini, B.; Bertoldi, M.; Paiardini, A.; D'Aguanno, S.; Voltattorni, C.B.
Site-directed mutagenesis provides insight into racemization and transamination of alanine catalyzed by Treponema denticola cystalysin
J. Biol. Chem.
279
36898-36905
2004
Treponema denticola
Yang, G.; Cao, K.; Wu, L.; Wang, R.
Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1
J. Biol. Chem.
279
49199-49205
2004
Rattus norvegicus (Q9EQS4)
Bloem, E.; Riemenschneider, A.; Volker, J.; Papenbrock, J.; Schmidt, A.; Salac, I.; Haneklaus, S.; Schnug, E.
Sulphur supply and infection with Pyrenopeziza brassicae influence L-cysteine desulphydrase activity in Brassica napus L
J. Exp. Bot.
55
2305-2312
2004
Brassica napus
Chen, C.; Xin, H.; Zhu, Y.
Hydrogen sulfide: third gaseous transmitter, but with great pharmacological potential
Acta Pharmacol. Sin.
28
1709-1716
2007
Rattus norvegicus
Hassan, S.S.; el-Baz, A.F.; Abd-Rabboh, H.S.
A novel potentiometric biosensor for selective L-cysteine determination using L-cysteine-desulfhydrase producing Trichosporon jirovecii yeast cells coupled with sulfide electrode
Anal. Chim. Acta
602
108-113
2007
Cutaneotrichosporon jirovecii
Yanfei, W.; Lin, S.; Junbao, D.; Chaoshu, T.
Impact of L-arginine on hydrogen sulfide/cystathionine-gamma-lyase pathway in rats with high blood flow-induced pulmonary hypertension
Biochem. Biophys. Res. Commun.
345
851-857
2006
Rattus norvegicus
Akahoshi, N.; Izumi, T.; Ishizaki, Y.; Ishii, I.
Differential induction of cystathionine gamma-lyase in the livers and kidneys of mouse dams during gestation and lactation
Biol. Pharm. Bull.
29
1799-1802
2006
Mus musculus, Rattus norvegicus
Gente, S.; La Carbona, S.; Gueguen, M.
Levels of cystathionine gamma lyase production by Geotrichum candidum in synthetic media and correlation with the presence of sulphur flavours in cheese
Int. J. Food Microbiol.
114
136-142
2007
Saccharomyces cerevisiae, Geotrichum candidum, Limosilactobacillus fermentum, Limosilactobacillus reuteri, Lactococcus lactis
Pong, W.W.; Stouracova, R.; Frank, N.; Kraus, J.P.; Eldred, W.D.
Comparative localization of cystathionine beta-synthase and cystathionine gamma-lyase in retina: differences between amphibians and mammals
J. Comp. Neurol.
505
158-165
2007
Ambystoma tigrinum, Mus musculus
Diwakar, L.; Ravindranath, V.
Inhibition of cystathionine-gamma-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS
Neurochem. Int.
50
418-426
2007
Homo sapiens, Mus musculus
Vermeij, P.; Kertesz, M.A.
Pathways of assimilative sulfur metabolism in Pseudomonas putida
J. Bacteriol.
181
5833-5837
1999
no activity in Pseudomonas putida, Pseudomonas aeruginosa, no activity in Pseudomonas putida S-313
Ngo, P.T.; Kim, J.K.; Kim, H.; Jung, J.; Ahn, Y.J.; Kim, J.G.; Lee, B.M.; Kang, H.W.; Kang, L.W.
Expression, crystallization and preliminary X-ray crystallographic analysis of XometC, a cystathionine gamma-lyase-like protein from Xanthomonas oryzae pv. oryzae
Acta Crystallogr. Sect. F
64
750-753
2008
Xanthomonas oryzae pv. oryzae (Q5H4T8), Xanthomonas oryzae pv. oryzae
Siebert, N.; Cantre, D.; Eipel, C.; Vollmar, B.
H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of K(ATP) channels
Am. J. Physiol. Gastrointest. Liver Physiol.
295
G1266-G1273
2008
Rattus norvegicus
Olson, K.R.; Healy, M.J.; Qin, Z.; Skovgaard, N.; Vulesevic, B.; Duff, D.W.; Whitfield, N.L.; Yang, G.; Wang, R.; Perry, S.F.
Hydrogen sulfide as an oxygen sensor in trout gill chemoreceptors
Am. J. Physiol. Regul. Integr. Comp. Physiol.
295
R669-R680
2008
Danio rerio, Oncorhynchus mykiss
Perry, S.F.; McNeill, B.; Elia, E.; Nagpal, A.; Vulesevic, B.
Hydrogen sulfide stimulates catecholamine secretion in rainbow trout (Oncorhynchus mykiss)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
296
R133-R140
2009
Oncorhynchus mykiss
Wrobel, M.; Lewandowska, I.; Bronowicka-Adamska, P.; Paszewski, A.
The level of sulfane sulfur in the fungus Aspergillus nidulans wild type and mutant strains
Amino Acids
37
565-571
2008
Aspergillus nidulans (B2LXT6), Aspergillus nidulans
Feng, X.; Chen, Y.; Zhao, J.; Tang, C.; Jiang, Z.; Geng, B.
Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator
Biochem. Biophys. Res. Commun.
380
153-159
2009
Rattus norvegicus
Zhu, W.; Lin, A.; Banerjee, R.
Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase
Biochemistry
47
6226-6232
2008
Homo sapiens (P32929), Homo sapiens
Bai, H.J.; Zhang, Z.M.; Yang, G.E.; Li, B.Z.
Bioremediation of cadmium by growing Rhodobacter sphaeroides: kinetic characteristic and mechanism studies
Biores. Technol.
99
7716-7722
2008
Cereibacter sphaeroides
Wang, Y.F.; Mainali, P.; Tang, C.S.; Shi, L.; Zhang, C.Y.; Yan, H.; Liu, X.Q.; DU, J.B.
Effects of nitric oxide and hydrogen sulfide on the relaxation of pulmonary arteries in rats
Chin. Med. Sci.
121
420-423
2008
Rattus norvegicus
Li, Y.; Zhao, Q.; Liu, X.L.; Wang, L.Y.; Lu, X.F.; Li, H.F.; Chen, S.F.; Huang, J.F.; Gu, D.F.
Relationship between cystathionine gamma-lyase gene polymorphism and essential hypertension in Northern Chinese Han population
Chin. Med. Sci.
121
716-720
2008
Homo sapiens
Bai, H.J.; Zhang, Z.M.; Guo, Y.; Yang, G.E.
Biosynthesis of cadmium sulfide nanoparticles by photosynthetic bacteria Rhodopseudomonas palustris
Colloids Surf. B Biointerfaces
70
142-146
2008
Rhodopseudomonas palustris
Hiraishi, H.; Miyake, T.; Ono, B.
Transcriptional regulation of Saccharomyces cerevisiae CYS3 encoding cystathionine gamma-lyase
Curr. Genet.
53
225-234
2008
Saccharomyces cerevisiae (P31373), Saccharomyces cerevisiae
Chen, Y.H.; Wu, R.; Geng, B.; Qi, Y.F.; Wang, P.P.; Yao, W.Z.; Tang, C.S.
Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma
Cytokine
45
117-123
2009
Rattus norvegicus
Bucci, M.; Mirone, V.; Di Lorenzo, A.; Vellecco, V.; Roviezzo, F.; Brancaleone, V.; Ciro, I.; Cirino, G.
Hydrogen Sulphide Is Involved in Testosterone Vascular Effect
Eur. Urol.
56
378-383
2008
Rattus norvegicus
Monjok, E.M.; Kulkarni, K.H.; Kouamou, G.; McKoy, M.; Opere, C.A.; Bongmba, O.N.; Njie, Y.F.; Ohia, S.E.
Inhibitory action of hydrogen sulfide on muscarinic receptor-induced contraction of isolated porcine irides
Exp. Eye Res.
87
612-616
2008
Sus scrofa
Kaneko, Y.; Kimura, T.; Taniguchi, S.; Souma, M.; Kojima, Y.; Kimura, Y.; Kimura, H.; Niki, I.
Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose
FEBS Lett.
583
377-382
2009
Mus musculus
Lo, R.; Turner, M.S.; Barry, D.G.; Sreekumar, R.; Walsh, T.P.; Giffard, P.M.
Cystathionine {gamma}-lyase is a component of cystine-mediated oxidative defense in Lactobacillus reuteri BR11
J. Bacteriol.
191
1827-1837
2009
Limosilactobacillus reuteri, Limosilactobacillus reuteri BR11
Sun, Q.; Collins, R.; Huang, S.; Holmberg-Schiavone, L.; Anand, G.S.; Tan, C.H.; van-den-Berg, S.; Deng, L.W.; Moore, P.K.; Karlberg, T.; Sivaraman, J.
Structural basis for the inhibition mechanism of human cystathionine {gamma}-lyase, an enzyme responsible for the production of H2S
J. Biol. Chem.
284
3076-3085
2009
Homo sapiens
Linden, D.R.; Sha, L.; Mazzone, A.; Stoltz, G.J.; Bernard, C.E.; Furne, J.K.; Levitt, M.D.; Farrugia, G.; Szurszewski, J.H.
Production of the gaseous signal molecule hydrogen sulfide in mouse tissues
J. Neurochem.
106
1577-1585
2008
Mus musculus, Mus musculus C57/BL6
Webb, G.D.; Lim, L.H.; Oh, V.M.; Yeo, S.B.; Cheong, Y.P.; Ali, M.Y.; El Oakley, R.; Lee, C.N.; Wong, P.S.; Caleb, M.G.; Salto-Tellez, M.; Bhatia, M.; Chan, E.S.; Taylor, E.A.; Moore, P.K.
Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery
J. Pharmacol. Exp. Ther.
324
876-882
2008
Rattus norvegicus, Homo sapiens (P32929), Homo sapiens
Tripatara, P.; Patel, N.S.; Collino, M.; Gallicchio, M.; Kieswich, J.; Castiglia, S.; Benetti, E.; Stewart, K.N.; Brown, P.A.; Yaqoob, M.M.; Fantozzi, R.; Thiemermann, C.
Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction
Lab. Invest.
88
1038-1048
2008
Rattus norvegicus
Wu, L.; Yang, W.; Jia, X.; Yang, G.; Duridanova, D.; Cao, K.; Wang, R.
Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats
Lab. Invest.
89
59-67
2009
Rattus norvegicus
Kulkarni, K.H.; Monjok, E.M.; Zeyssig, R.; Kouamou, G.; Bongmba, O.N.; Opere, C.A.; Njie, Y.F.; Ohia, S.E.
Effect of hydrogen sulfide on sympathetic neurotransmission and catecholamine levels in isolated porcine iris-ciliary body
Neurochem. Res.
34
400-406
2009
Sus scrofa
Lee, A.T.; Shah, J.J.; Li, L.; Cheng, Y.; Moore, P.K.; Khanna, S.
A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain
Neuroscience
152
89-96
2008
Rattus norvegicus
Tamizhselvi, R.; Moore, P.K.; Bhatia, M.
Inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury
Pancreas
36
e24-e31
2008
Mus musculus (Q8VCN5)
Patel, P.; Vatish, M.; Heptinstall, J.; Wang, R.; Carson, R.J.
The endogenous production of hydrogen sulphide in intrauterine tissues
Reprod. Biol. Endocrinol.
7
10
2009
Homo sapiens, Rattus norvegicus
Yang, G.; Wu, L.; Jiang, B.; Yang, W.; Qi, J.; Cao, K.; Meng, Q.; Mustafa, A.K.; Mu, W.; Zhang, S.; Snyder, S.H.; Wang, R.
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase
Science
322
587-590
2008
Mus musculus
Xu, M.; Wu, Y.M.; Li, Q.; Wang, X.; He, R.R.
Electrophysiological effects of hydrogen sulfide on pacemaker cells in sinoatrial nodes of rabbits
Sheng Li Xue Bao
60
175-180
2008
Oryctolagus cuniculus
Li, L.; Whiteman, M.; Moore, P.K.
Dexamethasone inhibits lipopolysacharide-induced hydrogen sulfide biosynthesis in intact cells and in an animal model of endotoxic shock
J. Cell. Mol. Med.
13
2684-2692
2008
Rattus norvegicus
Cao, Q.; Zhang, L.; Yang, G.; Xu, C.; Wang, R.
Butyrate-stimulated H2S production in colon cancer cells
Antioxid. Redox Signal.
12
1101-1109
2010
Homo sapiens
Farsi, A.; Lodha, P.H.; Skanes, J.E.; Los, H.; Kalidindi, N.; Aitken, S.M.
Interconversion of a pair of active-site residues in Escherichia coli cystathionine gamma-synthase, E. coli cystathionine beta-lyase, and Saccharomyces cerevisiae cystathionine gamma-lyase and development of tools for the investigation of their mechanisms
Biochem. Cell Biol.
87
445-457
2009
Saccharomyces cerevisiae
Chang, T.; Untereiner, A.; Liu, J.; Wu L.
Interaction of methylglyoxal and hydrogen sulfide in rat vascular smooth muscle cells
Antioxid. Redox Signal.
12
1093-1100
2010
Rattus norvegicus
Li, Q.; Sun. B.; Wang, X.; Jin, Z.; Zhou, Y.; Dong, L.; Jiang, L.H.; Rong, W.
A crucial role for hydrogen sulfide in oxygen sensing via modulating large conductance calcium-activated potassium channels
Antioxid. Redox Signal.
12
1179-1189
2010
Mus musculus
Bauer, C.C.; Boyle, J.P.; Porter, K.E., Peers, C.
Modulation of Ca2+ signalling in human vascular endothelial cells by hydrogen sulfide
Atherosclerosis
209
374-380
2010
Homo sapiens
Mancardi, D.; Penna, C.; Merlino, A.; Del Soldato, P.; Wink, D.A.; Pagliaro, P.
Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide
Biochim. Biophys. Acta
87
864-872
2009
Mus musculus
Zhu, X.Y.; Liu, S.J.; Liu, Y.J.; Wang, S.; Ni, X.
Glucocorticoids suppress cystathionine gamma-lyase expression and H2S production in lipopolysaccharide-treated macrophages
Cell. Mol. Life Sci.
67
1119-1132
2010
Mus musculus
Zhong, G.Z.; Yang, X.C.; Jia, L.P.; Chen, F.R.; Cui, M..
Inhibition of the cystathionine-gamma-lyase/hydrogen sulfide pathway in rat vascular smooth muscle cells by cobalt-60 gamma radiation
Chin. Med. J.
122
326-330
2009
Rattus norvegicus
Ohia, S.E.; Opere, C.A.; Monjok, E.M.; Kouamou, G.; Leday, A.M.; Njie-Mbye, Y.F.
Role of hydrogen sulfide production in inhibitory action of L-cysteine on isolated porcine irides
Curr. Eye Res.
35
402-407
2010
Sus scrofa
Martin, G.R.; McKnight, G.W.; Dicay, M.S.; Coffin, C.S.; Ferraz, J.G.; Wallace, J.L.
Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract
Dig. Liver Dis.
42
103-109
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Tripatara, P.; Patel, N.S.; Brancaleone, V.; Renshaw, D.; Rocha, J.; Sepodes, B.; Mota-Filipe, H.; Perretti, M.; Thiemermann, C.
Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study
Eur. J. Pharmacol.
606
205-209
2009
Mus musculus
Li, X.; Jin, H.; Bin, G.; Wang, L.; Tang, C.; Du, J.
Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow
Exp. Biol. Med.
234
504-512
2009
Rattus norvegicus
Irmler, S.; Schfer, H.; Beisert, B.; Rauhut, D.; Berthoud, H.
Identification and characterization of a strain-dependent cystathionine beta/gamma-lyase in Lactobacillus casei potentially involved in cysteine biosynthesis
FEMS Microbiol. Lett.
295
67-76
2009
Lacticaseibacillus casei (B3TNN8 and B3TNN9), Lacticaseibacillus casei
Nishimura, S.; Fukushima, O.; Ishikura, H.; Takahashi, T.; Matsunami, M.; Tsujiuchi, T.; Sekiguchi, F.; Naruse, M.; Kamanaka, Y.; Kawabata, A.
Hydrogen sulfide as a novel mediator for pancreatic pain in rodents
Gut
58
762-770
2009
Mus musculus, Rattus norvegicus
Chiku, T.; Padovani, D.; Zhu, W.; Singh, S.; Vitvitsky, V.; Banerjee, R.
H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia
J. Biol. Chem.
284
11601-11612
2009
Homo sapiens
Singh, S.; Padovani, D.; Leslie, R.A.; Chiku, T.; Banerjee, R.
Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions
J. Biol. Chem.
284
22457-22466
2009
Homo sapiens
Elsey, D.J.; Fowkes, R.C.; Baxter, G.F.
L-cysteine stimulates hydrogen sulfide synthesis in myocardium associated with attenuation of ischemia-reperfusion injury
J. Cardiovasc. Pharmacol. Ther.
15
53-59
2010
Rattus norvegicus
Wang, Q., Liu, H.R., Mu, Q., Rose, P., Zhu, Y.Z.
S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway
J. Cardiovasc. Pharmacol.
54
139-146
2009
Rattus norvegicus
Stipanuk, M.H.; Ueki, I.
Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur
J. Inherit. Metab. Dis.
34
17-32
2010
Homo sapiens
Huang, S.; Chua, J.H.; Yew, W.S.; Sivaraman, J.; Moore, P.K.; Tan, C.H.; Deng, L.W.
Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production
J. Mol. Biol.
396
708-718
2009
Homo sapiens
Gadalla, M.M.; Snyder, S.H.
Hydrogen sulfide as a gasotransmitter
J. Neurochem.
113
14-26
2010
Mus musculus
Xia, M.; Chen, L.; Muh, R.W.; Li, P.L.; Li, N.
Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys
J. Pharmacol. Exp. Ther.
329
1056-1062
2009
Rattus norvegicus
Srilatha, B.; Hu, L.; Adaikan, G.P.; Moore, P.K.
Initial characterization of hydrogen sulfide effects in female sexual function
J. Sex Med.
6
1875-1884
2009
Oryctolagus cuniculus
Kang, K.; Zhao, M.; Jiang, H.; Tan, G.; Pan, S.; Sun, X.
Role of hydrogen sulfide in hepatic ischemia-reperfusion-induced injury in rats
Liver Transpl.
15
1306-1314
2009
Rattus norvegicus
Lee, S.M.; Hwang, B.J.; Kim, Y.; Lee, H.S.
The cmaR gene of Corynebacterium ammoniagenes performs a novel regulatory role in the metabolism of sulfur-containing amino acids
Microbiology
155
1878-1889
2009
Corynebacterium ammoniagenes (B7UDE6)
Kraus, J.P.; Hasek, J.; Kozich, V.; Collard, R.; Venezia, S.; Janoskov, B.; Wang, J.; Stabler, S.P.; Allen, R.; Jakobs, C.; Finn, C.T.; Chien, Y.H.; Hwu, W.L.; Hegele, R.A.; Mudd, S.H.
Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies
Mol. Genet. Metab.
97
250-259
2009
Homo sapiens (P32929), Homo sapiens
Perna, A.F.; Luciano, M.G.; Ingrosso, D.; Pulzella, P.; Sepe, I.; Lanza, D.; Violetti, E.; Capasso, R.; Lombardi, C.; De Santo, N.G.
Hydrogen sulphide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes
Nephrol. Dial. Transplant.
24
3756-3763
2009
Homo sapiens (P32929), Homo sapiens
Lee, M.; Schwab, C.; Yu, S.; McGeer, E.; McGeer, P.L.
Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide
Neurobiol. Aging
30
1523-1534
2009
Homo sapiens
Tyagi, N.; Givvimani, S.; Qipshidze, N.; Kundu, S.; Kapoor, S.; Vacek, J.C.; Tyagi, S.C.
Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice
Neurochem. Int.
56
301-307
2010
Mus musculus
Kandil, S., Brennan, L., McBean, G.J.
Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells
Neurochem. Int.
56
611-619
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Opere, C.A.; Monjok, E.M.; Kulkarni, K.H.; Njie, Y.F.; Ohia, S.E.
Regulation of [3H] D-aspartate release from mammalian isolated retinae by hydrogen sulfide
Neurochem. Res.
34
1962-1968
2009
Sus scrofa
Fang, L.P.; Lin, Q.; Tang, C.S.; Liu, X.M.
Hydrogen sulfide attenuates epithelial-mesenchymal transition of human alveolar epithelial cells
Pharmacol. Res.
61
298-305
2009
Homo sapiens
Alvarez, C.; Calo, L.; Romero, L.C.; Garca, I.; Gotor, C.
An O-acetylserine(thiol)lyase homolog with L-cysteine desulfhydrase activity regulates cysteine homeostasis in Arabidopsis
Plant Physiol.
152
656-669
2009
Arabidopsis thaliana
dEmmanuele di Villa Bianca, R.; Sorrentino, R.; Maffia, P.; Mirone, V.; Imbimbo, C.; Fusco, F.; De Palma, R.; Ignarro, L.J.; Cirino, G.
Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation
Proc. Natl. Acad. Sci. USA
106
4513-4518
2009
Homo sapiens
Taniguchi, E.; Matsunami, M.; Kimura, T.; Yonezawa, D.; Ishiki, T.; Sekiguchi, F.; Nishikawa, H.,; Maeda, Y.; Ishikura, H.; Kawabata, A.
Rhodanese, but not cystathionine-gamma-lyase, is associated with dextran sulfate sodium-evoked colitis in mice: a sign of impaired colonic sulfide detoxification?
Toxicology
264
96-103
2009
Mus musculus, Rattus norvegicus
Roy, A.; Khan, A.H.; Islam, M.T.; Prieto, M.C.; Majid, D.S.
Interdependency of cystathione gamma-lyase and cystathione beta-synthase in hydrogen sulfide-induced blood pressure regulation in rats
Am. J. Hypertens.
25
74-81
2012
Rattus norvegicus
Jurkowska, H.; Placha, W.; Nagahara, N.; Wrobel, M.
The expression and activity of cystathionine-gamma-lyase and 3-mercaptopyruvate sulfurtransferase in human neoplastic cell lines
Amino Acids
41
151-158
2011
Homo sapiens
Knoll, C.; du Toit, M.; Schnell, S.; Rauhut, D.; Irmler, S.
Cloning and characterisation of a cystathionine beta/gamma-lyase from two Oenococcus oeni oenological strains
Appl. Microbiol. Biotechnol.
89
1051-1060
2011
Oenococcus oeni, Oenococcus oeni R1105
Mani, S.; Yang, G.; Wang, R.
A critical life-supporting role for cystathionine ?-lyase in the absence of dietary cysteine supply
Free Radic. Biol. Med.
50
1280-1287
2011
Mus musculus
Yang, G.; Pei, Y.; Teng, H.; Cao, Q.; Wang, R.
Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells
J. Biol. Chem.
286
26450-26460
2011
Homo sapiens
You, X.J.; Xu, C.; Lu, J.Q.; Zhu, X.Y.; Gao, L.; Cui, X.R.; Li, Y.; Gu, H.; Ni, X.
Expression of cystathionine beta-synthase and cystathionine gamma-lyase in human pregnant myometrium and their roles in the control of uterine contractility
PLoS ONE
6
e23788
2011
Homo sapiens
Bridges, C.C.; Krasnikov, B.F.; Joshee, L.; Pinto, J.T.; Hallen, A.; Li, J.; Zalups, R.K.; Cooper, A.J.
New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine gamma-lyase
Arch. Biochem. Biophys.
517
20-29
2012
Rattus norvegicus
Jin, Z.; Shen, J.; Qiao, Z.; Yang, G.; Wang, R.; Pei, Y.
Hydrogen sulfide improves drought resistance in Arabidopsis thaliana
Biochem. Biophys. Res. Commun.
414
481-486
2011
Arabidopsis thaliana (Q9M1R1), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q9M1R1)
Lee, Z.W.; Low, Y.L.; Huang, S.; Wang, T.; Deng, L.W.
The cystathionine beta-lyase/hydrogen sulfide system maintains cellular glutathione status
Biochem. J.
460
425-435
2014
Homo sapiens (P32929)
Hopwood, E.M.; Ahmed, D.; Aitken, S.M.
A role for glutamate-333 of Saccharomyces cerevisiae cystathionine gamma-lyase as a determinant of specificity
Biochim. Biophys. Acta
1844
465-472
2014
Saccharomyces cerevisiae
Reveal, B.S.; Paietta, J.V.
Analysis of the sulfur-regulated control of the cystathionine gamma-lyase gene of Neurospora crassa
BMC Res. Notes
5
339
2012
Neurospora crassa (Q96VU7), Neurospora crassa, Neurospora crassa 74OR23-1a (Q96VU7)
Asimakopoulou, A.; Panopoulos, P.; Chasapis, C.T.; Coletta, C.; Zhou, Z.; Cirino, G.; Giannis, A.; Szabo, C.; Spyroulias, G.A.; Papapetropoulos, A.
Selectivity of commonly used pharmacological inhibitors for cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE)
Br. J. Pharmacol.
169
922-932
2013
Escherichia coli
Manna, P.; Gungor, N.; McVie, R.; Jain, S.K.
Decreased cystathionine-gamma-lyase (CSE) activity in livers of type 1 diabetic rats and peripheral blood mononuclear cells (PBMC) of type 1 diabetic patients
J. Biol. Chem.
289
11767-11778
2014
Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Giordana, L.; Mantilla, B.S.; Santana, M.; Silber, A.M.; Nowicki, C.
Cystathionine gamma-lyase, an enzyme related to the reverse transsulfuration pathway, is functional in Leishmania spp.
J. Eukaryot. Microbiol.
61
204-213
2014
Leishmania mexicana, Leishmania major (E9AFE7)
Chernyshev, A.; Kotsyuba, E.
Cystathionine beta-synthase and cystathionine gamma-lyase in tissues of the nemertean Cerebratulus marginatus Renier, 1804 (nemertea)
Russ. J. Mar. Biol.
40
53-58
2014
Cerebratulus marginatus
-
Bhattacharjee, A.; Sinha, A.; Ratia, K.; Yin, L.; Delgado-Rivera, L.; Petukhov, P.A.; Thatcher, G.R.J.; Wardrop, D.J.
2-Arylidene hydrazinecarbodithioates as potent, selective inhibitors of cystathionine gamma-lyase (CSE)
ACS Med. Chem. Lett.
8
1241-1245
2017
Homo sapiens (P32929)
Leucker, T.M.; Nomura, Y.; Kim, J.H.; Bhatta, A.; Wang, V.; Wecker, A.; Jandu, S.; Santhanam, L.; Berkowitz, D.; Romer, L.; Pandey, D.
Cystathionine gamma-lyase protects vascular endothelium a role for inhibition of histone deacetylase 6
Am. J. Physiol. Heart Circ. Physiol.
312
H711-H720
2017
Homo sapiens (P32929), Mus musculus (Q8VCN5)
Yuan, S.; Yurdagul, A.; Peretik, J.M.; Alfaidi, M.; Al Yafeai, Z.; Pardue, S.; Kevil, C.G.; Orr, A.W.
Cystathionine gamma-lyase modulates flow-dependent vascular remodeling
Arterioscler. Thromb. Vasc. Biol.
38
2126-2136
2018
Mus musculus (Q8VCN5)
Gong, D.; Cheng, H.P.; Xie, W.; Zhang, M.; Liu, D.; Lan, G.; Huang, C.; Zhao, Z.W.; Chen, L.Y.; Yao, F.; Tan, Y.L.; Li, L.; Xia, X.D.; Zheng, X.L.; Wang, Z.B.; Tang, C.K.
Cystathionine gamma-lyase(CSE)/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway
Biochem. Biophys. Res. Commun.
470
107-116
2016
Homo sapiens
Mo, S.; Hua, Y.
Cystathionine gamma lyase-H2S contributes to osteoclastogenesis during bone remodeling induced by mechanical loading
Biochem. Biophys. Res. Commun.
501
471-477
2018
Mus musculus (Q8VCN5)
Yan, W.; Stone, E.; Zhang, Y.J.
Structural snapshots of an engineered cystathionine-gamma-lyase reveal the critical role of electrostatic interactions in the active site
Biochemistry
56
876-885
2017
Homo sapiens (P32929)
Yang, G.; Ju, Y.; Fu, M.; Zhang, Y.; Pei, Y.; Racine, M.; Baath, S.; Merritt, T.J.S.; Wang, R.; Wu, L.
Cystathionine gamma-lyase/hydrogen sulfide system is essential for adipogenesis and fat mass accumulation in mice
Biochim. Biophys. Acta
1863
165-176
2018
Mus musculus (Q8VCN5)
El-Sayed, A.S.; Abdel-Azeim, S.; Ibrahim, H.M.; Yassin, M.A.; Abdel-Ghany, S.E.; Esener, S.; Ali, G.S.
Biochemical stability and molecular dynamic characterization of Aspergillus fumigatus cystathionine gamma-lyase in response to various reaction effectors
Enzyme Microb. Technol.
81
31-46
2015
Aspergillus fumigatus (Q4WCI1), Aspergillus fumigatus ATCC MYA-4609 (Q4WCI1)
Han, S.J.; Noh, M.R.; Jung, J.M.; Ishii, I.; Yoo, J.; Kim, J.I.; Park, K.M.
Hydrogen sulfide-producing cystathionine gamma-lyase is critical in the progression of kidney fibrosis
Free Radic. Biol. Med.
112
423-432
2017
Mus musculus (Q8VCN5)
Maresi, E.; Janson, G.; Fruncillo, S.; Paiardini, A.; Vallone, R.; Dominici, P.; Astegno, A.
Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine gamma-lyase from Toxoplasma gondii
Int. J. Mol. Sci.
19
2111
2018
Toxoplasma gondii (B6K8Y1), Toxoplasma gondii ATCC 50861 (B6K8Y1)
Kumar, P.; Jander, G.
Concurrent overexpression of Arabidopsis thaliana cystathionine gamma-synthase and silencing of endogenous methionine gamma-lyase enhance tuber methionine content in Solanum tuberosum
J. Agric. Food Chem.
65
2737-2742
2017
Arabidopsis thaliana
El-Sayed, A.S.; Yassin, M.A.; Khalaf, S.A.; El-Batrik, M.; Ali, G.S.; Esener, S.
Biochemical and pharmacokinetic properties of PEGylated cystathionine gamma-lyase from Aspergillus carneus KF723837
J. Mol. Microbiol. Biotechnol.
25
301-310
2015
Aspergillus carneus, Aspergillus carneus KF723837
Tomuschat, C.; ODonnell, A.M.; Coyle, D.; Puri, P.
Reduction of hydrogen sulfide synthesis enzymes cystathionine-beta-synthase and cystathionine-gamma-lyase in the colon of patients with Hirschsprungs disease
J. Pediatr. Surg.
53
525-530
2018
Homo sapiens
Marko, L.; Szijarto, I.A.; Filipovic, M.R.; Kassmann, M.; Balogh, A.; Park, J.K.; Przybyl, L.; Ndiaye, G.; Kraemer, S.; Anders, J.; Ishii, I.; Mueller, D.N.; Gollasch, M.
Role of cystathionine gamma-lyase in immediate renal impairment and ionflammatory response in acute ischemic kidney injury
Sci. Rep.
6
27517
2016
Mus musculus (Q8VCN5)
html completed