4.4.1.1: cystathionine gamma-lyase
This is an abbreviated version!
For detailed information about cystathionine gamma-lyase, go to the full flat file.
Word Map on EC 4.4.1.1
-
4.4.1.1
-
sulfide
-
h2s
-
nahs
-
beta-synthase
-
sulfur
-
homocysteine
-
transsulfuration
-
pyridoxal
-
propargylglycine
-
dl-propargylglycine
-
gasotransmitter
-
cystathionine-beta-synthase
-
sulfurtransferase
-
gaseous
-
3-mercaptopyruvate
-
sulfur-containing
-
hydrosulfide
-
treponema
-
hyperhomocysteinemia
-
adenosyltransferase
-
l-methionine
-
desulfuration
-
glibenclamide
-
beta-lyase
-
denticola
-
vasorelaxation
-
hypotaurine
-
rhodanese
-
persulfide
-
alpha-ketobutyrate
-
d-cysteine
-
ppg
-
s-sulfhydration
-
h2s-producing
-
h2s-generating
-
medicine
-
cowden
-
gamma-synthase
-
synthesis
-
sulfhydrylase
-
analysis
-
aminooxyacetic
-
o-acetylserine
-
h2s-induced
-
remethylation
-
agriculture
-
cysteinesulfinate
-
nutrition
-
l-homoserine
-
biotechnology
-
cys3
-
aldimine
- 4.4.1.1
- sulfide
- h2s
- nahs
- beta-synthase
- sulfur
- homocysteine
-
transsulfuration
- pyridoxal
- propargylglycine
- dl-propargylglycine
-
gasotransmitter
- cystathionine-beta-synthase
- sulfurtransferase
-
gaseous
- 3-mercaptopyruvate
-
sulfur-containing
- hydrosulfide
- treponema
- hyperhomocysteinemia
-
adenosyltransferase
- l-methionine
-
desulfuration
- glibenclamide
-
beta-lyase
- denticola
-
vasorelaxation
- hypotaurine
- rhodanese
- persulfide
- alpha-ketobutyrate
- d-cysteine
- ppg
-
s-sulfhydration
-
h2s-producing
-
h2s-generating
- medicine
-
cowden
-
gamma-synthase
- synthesis
-
sulfhydrylase
- analysis
-
aminooxyacetic
- o-acetylserine
-
h2s-induced
-
remethylation
- agriculture
-
cysteinesulfinate
- nutrition
- l-homoserine
- biotechnology
- cys3
-
aldimine
Reaction
Synonyms
AFUA_8G04340, C-S-lyase, C-S-lyase1, C-S-lyase2, C-S-lyase3, C-S-lyase4, cgl, CGL like protein, CS-LIKE, CSE, CSEgamma, CTH, CTT, cystalysin, cystathionase, cystathioninase, cystathionine beta/gamma-lyase, cystathionine gamma lyase, cystathionine gamma-lyase, cystathionine gamma-lyase-like protein, cystathionine-gamma-lyase, cysteine desulfhydrase, cysteine lyase, cystine desulfhydrase, dehydratase, homoserine, DES1, desulfhydrase, cysteine, EC 4.2.1.15, gamma-CTL, gamma-CTLase, gamma-cystathionase, hCSE, homoserine deaminase, homoserine deaminase-cystathionase, homoserine dehydratase, human cystathionine-gamma-lyase, L-Cys desulfhydrase, L-cysteine desulfhydrase, L-cysteine desulphydrase, L-cysteine-desulfhydrase, LCD, lyase, cystathionine gamma-, PRB-RA, Probasin-related antigen, TGME49_112930, XometC, yCGL
ECTree
4.4.1.1 cystathionine gamma-lyaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.4.1.1 - cystathionine gamma-lyase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DL-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystine + 2 H2O
2 NH3 + 2 pyruvate + 2 hydrogen sulfide
-
-
-
?
L-homoserine
2-oxobutyrate + NH3
-
the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term
-
-
?
L-homoserine + 2-mercaptoethanol
S-hydroxyethyl-L-homocysteine
-
8% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + 4-mercaptobutanoate
S-carboxy-n-propyl-L-homocysteine
-
14% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + thioglycerol
S-(2,3-dihydroxypropyl)-L-homocysteine
-
5% of the activity with L-homocysteine and L-Cys
-
?
lanthionine + H2O
NH3 + ?
131% of activity compared to cystathionine
-
?
O-succinyl-L-homoserine
?
-
decomposed most rapidly of all the above substrates
-
-
?
S-(2-aminoethyl)-L-cysteine + H2O
NH3 + pyruvate + cysteamine
-
-
-
?
S-methyl-L-cysteine + H2O
NH3 + pyruvate + methyl mercaptan
-
-
-
?
D-Cys + L-homoserine
D-allocystathionine
-
at 318% of the activity with L-homocysteine and L-cysteine
-
?
D-Cys + L-homoserine
D-allocystathionine
-
gamma-replacement
-
-
?
D-Cys + L-homoserine
D-allocystathionine
-
gamma-replacement
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
alpha,gamma-elimination
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
alpha,gamma-elimination
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
alpha,gamma-elimination
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
-
r
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
alpha,gamma-elimination
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
alpha,gamma-elimination
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
-
-
-
?
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
?
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
alpha,beta-elimination
-
?
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
15% of activity compared to cystathionine
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
measurement of hydrogen sulfide production
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
measurement of hydrogen sulfide production
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
-
-
690781, 691828, 691972, 692207, 693818, 693936, 694398, 695079, 708133, 708300, 708411, 708627, 709212, 709676, 709778, 710627
-
-
?
L-cystine + H2O
NH3 + ?
133% of activity compared to cystathionine
-
?
L-djenkolic acid + H2O
NH3 + ?
24% of activity compared to cystathionine
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
-
-
-
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
-
-
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
-
gamma-replacement reaction
-
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
-
gamma-replacement reaction
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
-
73% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine
-
-
-
?
L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine
-
187% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine
-
gamma-replacement reaction
-
-
?
L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine
-
gamma-replacement reaction
-
?
L-homoserine + D-homocysteine
meso-homolanthionine
-
-
-
?
L-homoserine + D-homocysteine
meso-homolanthionine
-
gamma-replacement reaction, 368% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + H2O
2-oxobutanoate + NH3 + H2O
-
-
-
?
L-homoserine + L-homocysteine
L-homolanthionine
-
gamma-replacement reaction, 314% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + thioglycolate
S-carboxymethyl-L-homocysteine
-
gamma-replacement reaction, 69% of the activity with L-homocysteine and L-Cys
-
?
additional information
?
-
-
enzyme activity is required for high-level cephalosporin biosynthesis but not for low-level production of the antibiotic
-
?
additional information
?
-
Acremonium chrysogenum C10 / ATCC 48272
-
enzyme activity is required for high-level cephalosporin biosynthesis but not for low-level production of the antibiotic
-
?
additional information
?
-
-
cysteine desulfhydrase in Rhodobacter sphaeroides can produce sulfide under aerobic conditions and precipitate metal sulfide complexes on the cell wall
-
-
?
additional information
?
-
-
hydrogen sulfide is a gas signalling molecule which is produced endogenously from L-cysteine
-
-
?
additional information
?
-
-
enzyme responsible for amino acid catabolism
-
-
?
additional information
?
-
-
enzyme responsible for amino acid catabolism
-
-
?
additional information
?
-
-
activity decreases in the following order of substrates: L-cystathione, L-djenkolic, L-cystine, L-cysteine, L-methionine, L-serine
-
?
additional information
?
-
-
enzyme is able to demethiolate methionine into methanethiol
-
-
?
additional information
?
-
-
enzyme is able to demethiolate methionine into methanethiol
-
-
?
additional information
?
-
-
the Streptomyces enzyme has a lower substrate specificity than the rat-liver one
-
-
?
additional information
?
-
-
hydrogen sulfide is a gas signalling molecule which is produced endogenously from L-cysteine
-
-
?
additional information
?
-
-
responsible for the formation of nanocrystals
-
-
?
additional information
?
-
-
Glu333 of cystathionine gamma-lyase acts as a determinant of specificity, it interacts with the distal amine moiety of L-cystathionine, which is not present in the alternative substrate O-acetyl-L-serine. Catalytic efficiency of the yeast enzyme for alpha,gamma-elimination of O-succinyl-L-homoserine, which possesses a distal carboxylate, but lacks an amino group, is 300fold lower than that of the physiological L-cystathionine substrate and 260fold higher than that of L-Hcys, which lacks both distal polar moieties. Proposed polar contacts of the yCGL active site that interact with or are influenced by E48 and E333 overview
-
-
?
additional information
?
-
-
the Streptomyces enzyme has a lower substrate specificity than the rat-liver one
-
-
?
additional information
?
-
catalyzes the second step in the reverse-transsulfuration pathway, which is essential for the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine
-
-
?
additional information
?
-
-
catalyzes the second step in the reverse-transsulfuration pathway, which is essential for the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine
-
-
?
