4.4.1.1: cystathionine gamma-lyase

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For detailed information about cystathionine gamma-lyase, go to the full flat file.

Reaction

Synonyms

AFUA_8G04340, C-S-lyase, C-S-lyase1, C-S-lyase2, C-S-lyase3, C-S-lyase4, cgl, CGL like protein, CS-LIKE, CSE, CSEgamma, CTH, CTT, cystalysin, cystathionase, cystathioninase, cystathionine beta/gamma-lyase, cystathionine gamma lyase, cystathionine gamma-lyase, cystathionine gamma-lyase-like protein, cystathionine-gamma-lyase, cysteine desulfhydrase, cysteine lyase, cystine desulfhydrase, dehydratase, homoserine, DES1, desulfhydrase, cysteine, EC 4.2.1.15, gamma-CTL, gamma-CTLase, gamma-cystathionase, hCSE, homoserine deaminase, homoserine deaminase-cystathionase, homoserine dehydratase, human cystathionine-gamma-lyase, L-Cys desulfhydrase, L-cysteine desulfhydrase, L-cysteine desulphydrase, L-cysteine-desulfhydrase, LCD, lyase, cystathionine gamma-, PRB-RA, Probasin-related antigen, TGME49_112930, XometC, yCGL

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.1 cystathionine gamma-lyase

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12	Activating Compound
5091	AA Sequence
33	Application
1	CAS Registry Number
38	Cloned(Commentary)
81	Cofactor
7	Crystallization (Commentary)
319	Disease/ Diagnostics
34	Expression
28	General Information
2	General Stability
14	IC50 Value
183	Inhibitors
50	kcat/KM [mM/s]
1	Ki Value [mM]
112	KM Value [mM]
12	Localization
4	Metals/Ions
47	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
382	Organism
11	Pathway
100	PDB ID
22	pH Optimum
8	pH Range
1	pI Value
1	Posttranslational Modification
74	Protein Variants
27	Purification (Commentary)
7	Reaction
9	Reaction Type
209	Reference
238	Source Tissue
16	Specific Activity [micromol/min/mg]
6	Storage Stability
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31	Subunits
205	Synonyms
1	Systematic Name
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2	Temperature Range [°C]
19	Temperature Stability [°C]
61	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.4.1.1 - cystathionine gamma-lyase

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SYSTEMATIC NAME

IUBMB Comments

L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)

A multifunctional pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-cysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also catalyses the conversion of L-homoserine to 2-oxobutanoate and ammonia, of L-cystine to thiocysteine, pyruvate and ammonia, and of L-cysteine to pyruvate, hydrogen sulfide and ammonia.