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analysis
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use in biosensor for measurement of L-cysteine
biotechnology
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use of strain as adjunct starter in cheese making
agriculture
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infection with Pyrenopeziza brassicae led to increased LCD activity
agriculture
enzyme is an antibacterial drug-target protein against Xanthomonas oryzae pv. oryzae. Bacterial blight caused by Xanthomonas oryzae pv. oryzae is the most destructive bacterial disease of rice
medicine
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enzyme participates in hydrogen sulfide production in the oral cavity
medicine
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enzyme participates in hydrogen sulfide production in the oral cavity
medicine
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enzyme participates in hydrogen sulfide production in the oral cavity
medicine
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enzyme participates in hydrogen sulfide production in the oral cavity
medicine
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enzyme participates in hydrogen sulfide production in the oral cavity
medicine
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enzyme participates in hydrogen sulfide production in the oral cavity
medicine
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molecular basis of cystathioninuria, MIM 219500, revealed by mutations of enzyme
medicine
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physiologic importance of increased expression and activity of enzyme during lactation
medicine
high doses of pyridoxine could be an effective therapy for cystathioninuric patients harboring the T67I mutation and be somewhat less effective in ameliorating the symptoms associated with the Q240E mutation
medicine
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inhibition of CSE expression and reduction in formation of the pro-inflammatory component of H(2)S activity contributes to the anti-inflammatory effect of dexamethasone in endotoxic shock. Whether H(2)S plays a part in the anti-inflammatory effect of this steroid in other forms of inflammation such as arthritis or asthma warrants further study
medicine
inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury
medicine
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CSE is not associated with dextran sulfate sodium-induced colitis in mice
medicine
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CSE is not associated with dextran sulfate sodium-induced colitis in mice
medicine
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chronical treatment of rats with CGL inhibitor (DL)-propargylglycine or cystathionine beta-synthase inhibitor aminooxyacetic acid or a combination of both. Only the rats with combination therapy show a decrease in urinary sulfate excretion rate, which is associated with an increase in mean arterial pressure. Urine flow and sodium excretion are also increased in combination group as consequent to the increase in mean arterial pressure. Glomerular filtration rate does not alter due to these treatments, renal blood flow is lowered only in the combination group compared to the control group
medicine
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cumulative administration of L-cysteine causes a dose-dependent decrease in the amplitude of spontaneous contractions in nonlabouring and labouring myometrium strips. L-cysteine at high concentration increases the frequency of spontaneous contractions and induces tonic contraction. These effects of L-cysteine are blocked by inhibitors of cystathionen beta-synthase and cystathionine gamma-lyase. Pretreatment of myometrium strips with glibenclamide, an inhibitor of ATP-sensitive potassium channels, abolishes the inhibitory effect of L-cysteine on spontaneous contraction amplitude. The effects of L-cysteine on the amplitude of spontaneous contractions and baseline muscle tone are less potent in labouring tissues than that in nonlabouring strips
medicine
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covalent binding of enzyme to polyethylene glycol moieties reduces the specific activity from 59.71 U/mg of free enzyme to 48.71 U/mg, with a PEGylation yield of 81.5 and 70.7% modification of surface epsilon-amino groups. The pH stability does not change upon modification, and at 50 ° C, the thermal stability of PEG-CGL is increased by 40% in comparison to free CGL. By in vitro proteolysis, PEG-CGL retains more than 50% of its initial activity compared to less than 10% of the free-CGL for acid protease for 30 min. The biochemical and hematological responses of rabbits indicate nil toxicity of free and PEG-CGL
medicine
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cystathionine-beta-synthase and cystathionine-gamma-lyase are expressed in the normal human colon. Expression is significantly decreased in the ganglionic and aganglionic bowel of patients with Hirschsprung Disease. Expression in smooth muscles, interstitial cells of Cajal, platelet-derived growth factor-alpha receptor-positive cells, enteric neurons and colonic epithelium is markedly decreased in Hirschsprung Disease specimens compared to controls
medicine
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covalent binding of enzyme to polyethylene glycol moieties reduces the specific activity from 59.71 U/mg of free enzyme to 48.71 U/mg, with a PEGylation yield of 81.5 and 70.7% modification of surface epsilon-amino groups. The pH stability does not change upon modification, and at 50 ° C, the thermal stability of PEG-CGL is increased by 40% in comparison to free CGL. By in vitro proteolysis, PEG-CGL retains more than 50% of its initial activity compared to less than 10% of the free-CGL for acid protease for 30 min. The biochemical and hematological responses of rabbits indicate nil toxicity of free and PEG-CGL
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nutrition
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Lactobacillus fermentum is contained in the natural starter used for producing Parmesan cheese and as adventitious non-starter lactic acid bacteria. It also populates several Italian and Swiss cheeses. EC 4.4.1.1 is stable in the conditions of cheese ripening and may contribute to the biosynthesis of sulfur-containing compounds
nutrition
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Lactobacillus fermentum is contained in the natural starter used for producing Parmesan cheese and as adventitious non-starter lactic acid bacteria. It also populates several Italian and Swiss cheeses. EC 4.4.1.1 is stable in the conditions of cheese ripening and may contribute to the biosynthesis of sulfur-containing compounds
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synthesis
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effective at the end of trans-sulfuration pathway
synthesis
effective at the end of trans-sulfuration pathway
synthesis
effective at the end of trans-sulfuration pathway
synthesis
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effective in detoxification and biotransformation of Se
synthesis
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effective in metabolism of Se compounds
additional information
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H2S donors elicit pharmacological effect on ocular smooth muscle is of great interest and merits further investigation
additional information
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H2S is a physiologic vasodilator and regulator of blood pressure
additional information
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H2S might be a novel insulin resistance regulator
additional information
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insulin release is impaired in diabetic animals and inhibition of abnormally increased endogenous pancreatic H2S production in diabetes may represent a novel avenue for diabetes treatment