4.4.1.1: cystathionine gamma-lyase
This is an abbreviated version!
For detailed information about cystathionine gamma-lyase, go to the full flat file.
Word Map on EC 4.4.1.1
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4.4.1.1
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sulfide
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h2s
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nahs
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beta-synthase
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sulfur
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homocysteine
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transsulfuration
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pyridoxal
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propargylglycine
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dl-propargylglycine
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gasotransmitter
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cystathionine-beta-synthase
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sulfurtransferase
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gaseous
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3-mercaptopyruvate
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sulfur-containing
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hydrosulfide
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treponema
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hyperhomocysteinemia
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adenosyltransferase
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l-methionine
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desulfuration
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glibenclamide
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beta-lyase
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denticola
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vasorelaxation
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hypotaurine
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rhodanese
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persulfide
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alpha-ketobutyrate
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d-cysteine
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ppg
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s-sulfhydration
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h2s-producing
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h2s-generating
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medicine
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cowden
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gamma-synthase
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synthesis
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sulfhydrylase
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analysis
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aminooxyacetic
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o-acetylserine
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h2s-induced
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remethylation
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agriculture
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cysteinesulfinate
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nutrition
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l-homoserine
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biotechnology
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cys3
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aldimine
- 4.4.1.1
- sulfide
- h2s
- nahs
- beta-synthase
- sulfur
- homocysteine
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transsulfuration
- pyridoxal
- propargylglycine
- dl-propargylglycine
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gasotransmitter
- cystathionine-beta-synthase
- sulfurtransferase
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gaseous
- 3-mercaptopyruvate
-
sulfur-containing
- hydrosulfide
- treponema
- hyperhomocysteinemia
-
adenosyltransferase
- l-methionine
-
desulfuration
- glibenclamide
-
beta-lyase
- denticola
-
vasorelaxation
- hypotaurine
- rhodanese
- persulfide
- alpha-ketobutyrate
- d-cysteine
- ppg
-
s-sulfhydration
-
h2s-producing
-
h2s-generating
- medicine
-
cowden
-
gamma-synthase
- synthesis
-
sulfhydrylase
- analysis
-
aminooxyacetic
- o-acetylserine
-
h2s-induced
-
remethylation
- agriculture
-
cysteinesulfinate
- nutrition
- l-homoserine
- biotechnology
- cys3
-
aldimine
Reaction
Synonyms
AFUA_8G04340, C-S-lyase, C-S-lyase1, C-S-lyase2, C-S-lyase3, C-S-lyase4, cgl, CGL like protein, CS-LIKE, CSE, CSEgamma, CTH, CTT, cystalysin, cystathionase, cystathioninase, cystathionine beta/gamma-lyase, cystathionine gamma lyase, cystathionine gamma-lyase, cystathionine gamma-lyase-like protein, cystathionine-gamma-lyase, cysteine desulfhydrase, cysteine lyase, cystine desulfhydrase, dehydratase, homoserine, DES1, desulfhydrase, cysteine, EC 4.2.1.15, gamma-CTL, gamma-CTLase, gamma-cystathionase, hCSE, homoserine deaminase, homoserine deaminase-cystathionase, homoserine dehydratase, human cystathionine-gamma-lyase, L-Cys desulfhydrase, L-cysteine desulfhydrase, L-cysteine desulphydrase, L-cysteine-desulfhydrase, LCD, lyase, cystathionine gamma-, PRB-RA, Probasin-related antigen, TGME49_112930, XometC, yCGL
ECTree
4.4.1.1 cystathionine gamma-lyaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 4.4.1.1 - cystathionine gamma-lyase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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expression of both cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase, the activity of 3-mercaptopyruvate sulfurtransferase is higher than that of cystathionine gamma-lyase
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mainly expressed in airway and vascular smooth muscle cells in rat lung tissue
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whole cells, cell lysate of a culture broth, cell wall of a subcellular fraction
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high expression in cerebral organs and in the epithelium of the lateral cephalic slits through which these organs open to the outside, highest in the cerebral organs in the cells lining the inner channel and also in the rear cluster of neuro-glandular cells
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of the canals of the cerebral organs, enzyme expression
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CSE is localized in the muscular trabeculae and the smooth-muscle component of the penile artery
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only in the anterior- and the postero-lateral areas of the body
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order of hydrogen sulfide production rates for different tissues are: liver (777 nM/min/g), followed by uterus (168 nM/min/g), fetal membranes (22.3 nM/min/g), placenta (11.1 nM/min/g), compared to human placenta (200 nM/min/g)
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in neurons and nerve fibers of the lateral nerve cords immediately behind the ventral ganglia
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pregnant myometrium, primarily localized to smooth muscle cells of pregnant myometrium
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peripheral blood mononuclear cells, PBMC, isolated from healthy subjects and type 1 diabetic patients
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primarily localized to smooth muscle cells of pregnant myometrium
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order of hydrogen sulfide production rates for different tissues are: liver (777 nM/min/g), followed by uterus (168 nM/min/g), fetal membranes (22.3 nM/min/g), placenta (11.1 nM/min/g), compared to human placenta (200 nM/min/g)
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expression of both cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase, the activity of 3-mercaptopyruvate sulfurtransferase is higher than that of cystathionine gamma-lyase
additional information
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predominantly localized to the endothelial layer of blood vessels
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with a decreasing activity in tail artery, aorta and mesenteric arteries
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activity in human brain is 100fold higher than that observed in mouse brain
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in the brain, where CSE levels are low, localizations are predominantly in white matter
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cystathionine-beta-synthase and cystathionine-gamma-lyase are expressed in the normal human colon. Expression is significantly decreased in the ganglionic and aganglionic bowel of patients with Hirschsprung Disease
only in adult tissue, not detectable in fetal, premature and full-term neonatal liver
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5584, 34486, 34488, 34490, 34491, 34492, 34493, 34494, 34495, 34496, 34498, 34500, 34501, 672489, 690352, 690781, 693818, 694398, 708300, 709778, 721432
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order of hydrogen sulfide production rates for different tissues are: liver (777 nM/min/g), followed by uterus (168 nM/min/g), fetal membranes (22.3 nM/min/g), placenta (11.1 nM/min/g), compared to human placenta (200 nM/min/g)
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mainly expressed in airway and vascular smooth muscle cells in rat lung tissue
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order of hydrogen sulfide production rates for different tissues are: liver (777 nM/min/g), followed by uterus (168 nM/min/g), fetal membranes (22.3 nM/min/g), placenta (11.1 nM/min/g), compared to human placenta (200 nM/min/g)
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expression of both cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase, the activity of 3-mercaptopyruvate sulfurtransferase is higher than that of cystathionine gamma-lyase. The low level of cystathionine gamma-lyase and low GSH/GSSG ratio correspond with the highest cystathionine gamma-lyase activity mong the cell lines tested
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expression of both cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase, the activity of 3-mercaptopyruvate sulfurtransferase is higher than that of cystathionine gamma-lyase. Very low activity of cystathionine gamma-lyase
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order of hydrogen sulfide production rates for different tissues are: liver (777 nM/min/g), followed by uterus (168 nM/min/g), fetal membranes (22.3 nM/min/g), placenta (11.1 nM/min/g), compared to human placenta (200 nM/min/g)
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mainly expressed in airway and vascular smooth muscle cells in rat lung tissue
additional information
the enzyme expression levels gradually increases in an age-dependent manner, expression profiling, overview
additional information
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the enzyme expression levels gradually increases in an age-dependent manner, expression profiling, overview
additional information
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the enzyme expression levels gradually increases in an age-dependent manner, expression profiling, overview
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