4.4.1.1: cystathionine gamma-lyase

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For detailed information about cystathionine gamma-lyase, go to the full flat file.

Reaction

Synonyms

AFUA_8G04340, C-S-lyase, C-S-lyase1, C-S-lyase2, C-S-lyase3, C-S-lyase4, cgl, CGL like protein, CS-LIKE, CSE, CSEgamma, CTH, CTT, cystalysin, cystathionase, cystathioninase, cystathionine beta/gamma-lyase, cystathionine gamma lyase, cystathionine gamma-lyase, cystathionine gamma-lyase-like protein, cystathionine-gamma-lyase, cysteine desulfhydrase, cysteine lyase, cystine desulfhydrase, dehydratase, homoserine, DES1, desulfhydrase, cysteine, EC 4.2.1.15, gamma-CTL, gamma-CTLase, gamma-cystathionase, hCSE, homoserine deaminase, homoserine deaminase-cystathionase, homoserine dehydratase, human cystathionine-gamma-lyase, L-Cys desulfhydrase, L-cysteine desulfhydrase, L-cysteine desulphydrase, L-cysteine-desulfhydrase, LCD, lyase, cystathionine gamma-, PRB-RA, Probasin-related antigen, TGME49_112930, XometC, yCGL

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.1 cystathionine gamma-lyase

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Results	in table
12	Activating Compound
5091	AA Sequence
33	Application
1	CAS Registry Number
38	Cloned(Commentary)
81	Cofactor
7	Crystallization (Commentary)
319	Disease/ Diagnostics
34	Expression
28	General Information
2	General Stability
14	IC50 Value
183	Inhibitors
50	kcat/KM [mM/s]
1	Ki Value [mM]
112	KM Value [mM]
12	Localization
4	Metals/Ions
47	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
382	Organism
11	Pathway
100	PDB ID
22	pH Optimum
8	pH Range
1	pI Value
1	Posttranslational Modification
74	Protein Variants
27	Purification (Commentary)
7	Reaction
9	Reaction Type
209	Reference
238	Source Tissue
16	Specific Activity [micromol/min/mg]
6	Storage Stability
331	Substrates and Products (Substrate)
31	Subunits
205	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
2	Temperature Range [°C]
19	Temperature Stability [°C]
61	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 4.4.1.1 - cystathionine gamma-lyase

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0.0647

Lactococcus lactis

-

-

34509

0.49

2 entries

10

Rattus norvegicus

-

-

5584

11.5

Lactococcus lactis

A2RM21

substrate cystathionine

651351

13.8

Aspergillus fumigatus

Q4WCI1

pH 8.0, 37°C

747679

2.6

Streptomyces phaeochromogenes

-

-

34484, 586904

24

Rattus norvegicus

-

purified liver enzyme, pH 7.4, 37°C

721432

48.71

Aspergillus carneus

-

protein bound to polyethylene glycol, pH not specified in the publication, temperature not specified in the publication

748430

59.71

Aspergillus carneus

-

native enzyme, pH not specified in the publication, temperature not specified in the publication

748430

additional information

5 entries

0.49

Leishmania major

E9AFE7

cell-free extract of promastigotes, pH 8.0, 37°C

730121

0.49

Leishmania mexicana

-

cell-free extract of promastigotes, pH 8.0, 37°C

730121

additional information

Homo sapiens

-

-

34508

additional information

Limosilactobacillus fermentum

-

-

34506

additional information

Mus musculus

-

-

34502

additional information

Neurospora sp.

-

-

34487

additional information

Neurospora sp.

-

-

34499