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4.4.1.1: cystathionine gamma-lyase

This is an abbreviated version!
For detailed information about cystathionine gamma-lyase, go to the full flat file.

Word Map on EC 4.4.1.1

Reaction

2-aminobut-2-enoate
=
2-iminobutanoate

Synonyms

AFUA_8G04340, C-S-lyase, C-S-lyase1, C-S-lyase2, C-S-lyase3, C-S-lyase4, cgl, CGL like protein, CS-LIKE, CSE, CSEgamma, CTH, CTT, cystalysin, cystathionase, cystathioninase, cystathionine beta/gamma-lyase, cystathionine gamma lyase, cystathionine gamma-lyase, cystathionine gamma-lyase-like protein, cystathionine-gamma-lyase, cysteine desulfhydrase, cysteine lyase, cystine desulfhydrase, dehydratase, homoserine, DES1, desulfhydrase, cysteine, EC 4.2.1.15, gamma-CTL, gamma-CTLase, gamma-cystathionase, hCSE, homoserine deaminase, homoserine deaminase-cystathionase, homoserine dehydratase, human cystathionine-gamma-lyase, L-Cys desulfhydrase, L-cysteine desulfhydrase, L-cysteine desulphydrase, L-cysteine-desulfhydrase, LCD, lyase, cystathionine gamma-, PRB-RA, Probasin-related antigen, TGME49_112930, XometC, yCGL

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.1 cystathionine gamma-lyase

Inhibitors

Inhibitors on EC 4.4.1.1 - cystathionine gamma-lyase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(DL)-propargylglycine
-
chronical treatment of rats with CGL inhibitor (DL)-propargylglycine or cystathionine beta-synthase inhibitor aminooxyacetic acid or a combination of both. Only the rats with combination therapy show a decrease in urinary sulfate excretion rate, which is associated with an increase in mean arterial pressure. Urine flow and sodium excretion are also increased in combination group as consequent to the increase in mean arterial pressure. Glomerular filtration rate does not alter due to these treatments, renal blood flow is lowered only in the combination group compared to the control group
1,10-phenanthroline
-
2 mM, 20% inhibition
1-nitroso-2-naphthol-3,6-disulfonic acid
-
2 mM, 55% inhibition
2-(4-methoxyanilino)-2-oxoethyl-(2E)-2-[(3-fluoropyridin-2-yl)methylidene]hydrazine-1-carbodithioate
compound shows at least 400fold selectivity for CSEgamma over inhibition of cystathionine beta-synthase
2-(prop-2-yn-1-ylamino)acetic acid
-
-
3-methyl-2-benzothiazolinone
-
31% residual activity at 5 mM
3-Methyl-2-benzothiazolinone hydrazone
4-chloromercuribenzoate
-
-
5,5'-dithiobis(2-nitrobenzoate)
6-diazo-5-oxonorleucine
-
-
8-Hydroxyquinoline-5-sulfonic acid
-
2 mM, 13% inhibition
acetoacetate
-
treatment with 0.025-0.035 mM H2O2, 4-8 mM acetoacetate and high D-glucose of 25 mM causes a significant decrease in enzyme protein expression, enzyme activity, and H2S levels, and an increase in intracellular reactive oxygen species production compared with those in normal controls
AgNO3
-
alpha,beta-elimination L-homoserine
Ala
-
competitive
alpha-amino-gamma-aminooxybutanoate
-
-
aminoethoxyvinylglycine
-
-
Aminooxyacetate
-
-
aminooxyacetic acid
beta,beta,beta-trifluoroalanine
beta-cyano-L-Ala
-
alpha,beta-elimination L-homoserine
Beta-cyano-L-alanine
Beta-cyanoalanine
beta-trifluoromethyl-D,L-Ala
-
i.e. 2-amino-4,4,4-trifluorobutanoate
Ca2+
-
0.1 mM, weak
carboxymethoxylamine
-
-
Cd2+
-
strong
CH3-Hg-S-Cys
-
the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor
Co2+
-
0.1 mM, weak
Cr2+
-
0.1 mM, weak
Cu2+
-
strong
cycloserine
Cys-S-Hg-S-Cys
-
the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor
cysteamine
-
-
D-glucose
-
treatment with 0.025-0.035 mM H2O2, 4-8 mM acetoacetate and high D-glucose of 25 mM causes a significant decrease in enzyme protein expression, enzyme activity, and H2S levels, and an increase in intracellular reactive oxygen species production compared with those in normal controls
dichloro-D,L-Ala
-
-
DL-Penicillamine
-
3% residual activity at 5 mM
DL-propargylalanine
-
-
DL-propargylglycine
EDTA
-
2 mM, 13% inhibition
Fe2+
-
0.1 mM, weak
Fe3+
-
0.1 mM, weak
Gly
-
competitive
H2O2
-
treatment with 0.025-0.035 mM H2O2, 4-8 mM acetoacetate and high D-glucose of 25 mM causes a significant decrease in enzyme protein expression, enzyme activity, and H2S levels, and an increase in intracellular reactive oxygen species production compared with those in normal controls
HgCl2
-
a potent irreversible enzyme inhibitor, but HgCl2 is also a strong inactivator of cystathionine gamma-lyase
hydroxylamine
iodoacetamide
-
22% residual activity at 2.5 mM
iodoacetate
-
-
Iodosobenzoate
-
-
isoniazid
-
-
Isonicotinic acid hydrazide
-
-
L-aminoethoxyvinylglycine
-
-
L-Asn
-
weak
L-beta-oxalyl amino-L-alanine
-
inhibition only after long exposure
L-cysteine
L-Met
-
weak
L-propargylglycine
-
-
L-Thr
-
weak
L-Val
-
weak
Mercurials
-
-
-
Mg2+
-
0.1 mM, weak
Mn2+
-
0.1 mM, weak
N-ethylmaleimide
N-prop-2-yn-1-ylglycine
-
-
NEM
-
0.05 mM, inhibition is partly relieved by 0.2 mM 2,3-dimercaptopropanol
NH4Cl/NH4OH buffer
-
-
Ni2+
-
0.1 mM, weak
O2
-
homogenized gills produces H2S enzymatically, and H2S production is inhibited by O2, whereas mitchondrial H2S consumption is O2 dependent
Penicillamine
phenylhydrazine
propargyl glycine
-
-
propargylglycine
Semicarbazide
Ser
-
competitive
Sodium bisulfite
-
-
Sodium borohydride
-
-
Sodium cyanide
-
alpha,beta-elimination, 1 mM, 82% inhibition
streptozotocin
-
livers from streptozotocin-treated type I diabetic rats have lower levels of enzyme protein expression, enzyme activity, reduced tissue H2S formation, and increased reactive oxygen species production compared with those of controls
trifluoro-Ala
trifluoroalanine
-
-
additional information
-