Information on EC 4.4.1.1 - cystathionine gamma-lyase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
4.4.1.1
-
RECOMMENDED NAME
GeneOntology No.
cystathionine gamma-lyase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-aminobut-2-enoate = 2-iminobutanoate
show the reaction diagram
spontaneous
-
-
-
2-iminobutanoate + H2O = 2-oxobutanoate + NH3
show the reaction diagram
spontaneous
-
-
-
L-cystathionine + H2O = L-cysteine + 2-oxobutanoate + NH3
show the reaction diagram
L-cystathionine = L-cysteine + 2-aminobut-2-enoate
show the reaction diagram
(1a)
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alpha,beta-elimination
-
-
alpha,gamma-elimination
-
-
elimination
-
-
of H2S or RSH, C-S bond cleavage
-
hydrolysis
transamination
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
-
-
Cysteine and methionine metabolism
-
-
cysteine metabolism
-
-
Glycine, serine and threonine metabolism
-
-
Metabolic pathways
-
-
Selenocompound metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
A multifunctional pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-cysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also catalyses the conversion of L-homoserine to 2-oxobutanoate and ammonia, of L-cystine to thiocysteine, pyruvate and ammonia, and of L-cysteine to pyruvate, hydrogen sulfide and ammonia.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-96-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
C10
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
infected with Pyrenopeziza brassicae
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain ATCC 334
B3TNN8 and B3TNN9
UniProt
Manually annotated by BRENDA team
DT41
-
-
Manually annotated by BRENDA team
BR11
-
-
Manually annotated by BRENDA team
gene LmjF35.3230 or Lmj_CGL
UniProt
Manually annotated by BRENDA team
Mus musculus C57/BL6
C57/Bl6 strain
-
-
Manually annotated by BRENDA team
gene cys-16+
UniProt
Manually annotated by BRENDA team
gene cys-16+
UniProt
Manually annotated by BRENDA team
Neurospora sp. ATCC-10816
ATCC-10816
-
-
Manually annotated by BRENDA team
no activity in Pseudomonas putida
-
-
-
Manually annotated by BRENDA team
no activity in Pseudomonas putida S-313
-
-
-
Manually annotated by BRENDA team
Nocardia erythropolis
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain PAO1
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
-
-
-
Manually annotated by BRENDA team
LC-67
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
additional information
the Leishmania major enzyme is able to rescue the wild-type phenotype of a Saccharomyces cerevisiae enzyme-null mutant
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(DL)-homocysteine
H2S + ?
show the reaction diagram
3-chloro-2-aminobutanoate
?
show the reaction diagram
-
-
-
-
?
3-chloro-DL-alanine + H2O
NH3 + ?
show the reaction diagram
-
-
-
?
alpha,beta-diaminopropionate
?
show the reaction diagram
-
beta,gamma-elimination
-
-
?
beta-chloro-L-Ala
?
show the reaction diagram
beta-chloro-L-alanine + H2O
pyruvate + NH3 + HCl
show the reaction diagram
-
-
-
-
?
beta-methylcystine
?
show the reaction diagram
-
-
-
-
?
cysteine
H2S
show the reaction diagram
-
-
-
-
?
cystine
H2S + NH3 + pyruvate + L-thiocysteine
show the reaction diagram
D-Cys + D-homoserine
D-cystathionine
show the reaction diagram
-
-
-
?
D-Cys + L-homoserine
D-allocystathionine
show the reaction diagram
djenkolic acid
?
show the reaction diagram
DL-cystathionine
?
show the reaction diagram
-
-
-
?
DL-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
show the reaction diagram
-
-
-
?
DL-vinylglycine
?
show the reaction diagram
homocysteine
?
show the reaction diagram
-
beta,gamma-elimination
-
-
?
L-Cys
H2S + NH3 + pyruvate
show the reaction diagram
L-Cys + D-homoserine
L-allocystathionine
show the reaction diagram
-
-
-
?
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
show the reaction diagram
L-cystathionine
2-oxobutyrate + L-cysteine + NH3
show the reaction diagram
-
-
-
-
?
L-cystathionine
homocysteine + pyruvate + NH3
show the reaction diagram
L-cystathionine
L-cysteine + 2-oxobutanoate + NH3
show the reaction diagram
L-cystathionine
L-homocysteine + pyruvate + NH3
show the reaction diagram
L-cystathionine
L-homoserine + L-cysteine
show the reaction diagram
-
-
-
?
L-cystathionine + H2O
?
show the reaction diagram
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH
show the reaction diagram
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
show the reaction diagram
L-cystathionine + H2O
L-cysteine + ?
show the reaction diagram
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + NH3 + 2-oxobutanoate
show the reaction diagram
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
show the reaction diagram
L-cysteine + H2O
H2S + pyruvate + NH3
show the reaction diagram
L-cysteine + H2O
sulfide + NH3 + pyruvate
show the reaction diagram
L-cysteine + L-cysteine
H2S + L-lanthionine
show the reaction diagram
-
-
-
-
?
L-cysteine + L-cysteine
L-lanthionine + H2S
show the reaction diagram
-
-
-
-
?
L-cystine
?
show the reaction diagram
L-cystine
H2S + NH3 + pyruvate
show the reaction diagram
L-cystine
H2S + NH3 + pyruvate + L-thiocysteine
show the reaction diagram
-
-
-
?
L-cystine
pyruvate + NH3
show the reaction diagram
-
-
-
-
?
L-cystine
thiocysteine + pyruvate + NH3
show the reaction diagram
-
-
-
-
?
L-cystine + H2O
NH3 + ?
show the reaction diagram
L-cystine + H2O
NH3 + pyruvate + hydrogen sulfide
show the reaction diagram
-
-
-
?
L-cystine + H2O
thiocysteine + pyruvate + NH3
show the reaction diagram
-
-
-
-
?
L-djenkolic acid + H2O
NH3 + ?
show the reaction diagram
L-homocysteine
?
show the reaction diagram
L-homocysteine + H2O
H2S + ?
show the reaction diagram
-
-
-
-
?
L-homocysteine + H2O
NH3 + 2-oxobutanoate + H2S
show the reaction diagram
-
-
-
-
?
L-homocysteine + L-cysteine
L-cystathionine + H2S
show the reaction diagram
-
-
-
-
?
L-homocysteine + L-homocysteine
L-homolanthionine + H2S
show the reaction diagram
-
-
-
-
?
L-homocystine
?
show the reaction diagram
-
-
-
-
?
L-homoserine
2-oxobutyrate + NH3
show the reaction diagram
-
the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term
-
-
?
L-homoserine
?
show the reaction diagram
L-homoserine + 2-mercaptoethanol
S-hydroxyethyl-L-homocysteine
show the reaction diagram
-
8% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + 2-mercaptopropionate
S-methylcarboxymethyl-L-homocysteine
show the reaction diagram
L-homoserine + 3-mercaptopropionate
S-carboxyethyl-L-homocysteine
show the reaction diagram
L-homoserine + 4-mercaptobutanoate
S-carboxy-n-propyl-L-homocysteine
show the reaction diagram
-
14% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + D-homocysteine
meso-homolanthionine
show the reaction diagram
L-homoserine + H2O
2-oxobutanoate + NH3 + H2O
show the reaction diagram
L-homoserine + H2O
H2O + NH3 + 2-oxobutanoate
show the reaction diagram
-
-
-
-
?
L-homoserine + H2O
NH3 + ?
show the reaction diagram
-
-
-
?
L-homoserine + L-Cys
L-cystathionine
show the reaction diagram
L-homoserine + L-homocysteine
L-homolanthionine
show the reaction diagram
L-homoserine + thioglycerol
S-(2,3-dihydroxypropyl)-L-homocysteine
show the reaction diagram
-
5% of the activity with L-homocysteine and L-Cys
-
?
L-homoserine + thioglycolate
S-carboxymethyl-L-homocysteine
show the reaction diagram
L-Met
methanethiol + ?
show the reaction diagram
L-methionine + H2O
NH3 + ?
show the reaction diagram
L-serine + H2O
NH3 + ?
show the reaction diagram
-
-
-
?
Lanthionine
?
show the reaction diagram
lanthionine + H2O
NH3 + ?
show the reaction diagram
131% of activity compared to cystathionine
-
?
meso-cystine
?
show the reaction diagram
mixed disulfide of L-cystine and L-homocystine
?
show the reaction diagram
-
-
-
-
?
O-acetyl-L-homoserine
?
show the reaction diagram
-
-
-
-
?
O-acetyl-L-homoserine + H2O
NH3 + ?
show the reaction diagram
-
-
-
?
O-acetyl-L-serine + H2O
acetate + pyruvate + NH3
show the reaction diagram
-
-
-
-
?
O-succinyl-L-homoserine
?
show the reaction diagram
-
decomposed most rapidly of all the above substrates
-
-
?
O-succinyl-L-homoserine + H2O
NH3 + ?
show the reaction diagram
-
-
-
?
S-(2-aminoethyl)-L-cysteine + H2O
NH3 + pyruvate + cysteamine
show the reaction diagram
-
-
-
?
S-aminoethyl-L-Cys
?
show the reaction diagram
S-methyl-L-Cys
?
show the reaction diagram
S-methyl-L-cysteine + H2O
NH3 + pyruvate + methyl mercaptan
show the reaction diagram
-
-
-
?
seleno-L-methionine
methylselenol + 2-oxobutyrate + NH3
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-cystathione + H2O
L-cysteine + NH3 + 2-oxobutanoate
show the reaction diagram
L-cystathionine
2-oxobutyrate + L-cysteine + NH3
show the reaction diagram
-
-
-
-
?
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH
show the reaction diagram
L-cystathionine + H2O
L-cysteine + 2-oxobutanoate + NH3
show the reaction diagram
L-cystathionine + H2O
L-homocysteine + pyruvate + NH3
show the reaction diagram
L-cysteine + H2O
H2S + pyruvate + NH3
show the reaction diagram
L-cysteine + H2O
sulfide + NH3 + pyruvate
show the reaction diagram
L-cystine
pyruvate + NH3
show the reaction diagram
-
-
-
-
?
L-homoserine
2-oxobutyrate + NH3
show the reaction diagram
-
the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term
-
-
?
L-homoserine + H2O
2-oxobutanoate + NH3 + H2O
show the reaction diagram
B3TNN8 and B3TNN9
-
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
Ca2+ promotes activation of CSE, H2S production by CSE is a Ca2+-dependent phenomenon
HgCl2
-
a potent irreversible enzyme inhibitor, but HgCl2 is also a strong inactivator of cystathionine gamma-lyase
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(DL)-propargylglycine
-
chronical treatment of rats with CGL inhibitor (DL)-propargylglycine or cystathionine beta-synthase inhibitor aminooxyacetic acid or a combination of both. Only the rats with combination therapy show a decrease in urinary sulfate excretion rate, which is associated with an increase in mean arterial pressure. Urine flow and sodium excretion are also increased in combination group as consequent to the increase in mean arterial pressure. Glomerular filtration rate does not alter due to these treatments, renal blood flow is lowered only in the combination group compared to the control group
1,10-phenanthroline
-
2 mM, 20% inhibition
1-nitroso-2-naphthol-3,6-disulfonic acid
-
2 mM, 55% inhibition
2-(prop-2-yn-1-ylamino)acetic acid
-
-
3-methyl-2-benzothiazolinone
-
31% residual activity at 5 mM
3-Methyl-2-benzothiazolinone hydrazone
4-chloromercuribenzoate
-
-
5,5'-dithiobis(2-nitrobenzoate)
8-Hydroxyquinoline-5-sulfonic acid
-
2 mM, 13% inhibition
acetoacetate
-
treatment with 0.025-0.035 mM H2O2, 4-8 mM acetoacetate and high D-glucose of 25 mM causes a significant decrease in enzyme protein expression, enzyme activity, and H2S levels, and an increase in intracellular reactive oxygen species production compared with those in normal controls
AgNO3
-
alpha,beta-elimination L-homoserine
Ala
-
competitive
alpha-amino-gamma-aminooxybutanoate
-
-
aminoethoxyvinylglycine
-
-
Aminooxyacetate
-
-
aminooxyacetic acid
beta,beta,beta-trifluoroalanine
beta-cyano-L-Ala
-
alpha,beta-elimination L-homoserine
Beta-cyano-L-alanine
Beta-cyanoalanine
beta-trifluoromethyl-D,L-Ala
-
i.e. 2-amino-4,4,4-trifluorobutanoate
Ca2+
-
0.1 mM, weak
carboxymethoxylamine
-
-
Cd2+
-
strong
CH3-Hg-S-Cys
-
the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor
Co2+
-
0.1 mM, weak
Cr2+
-
0.1 mM, weak
Cu2+
-
strong
cycloserine
Cys-S-Hg-S-Cys
-
the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor
cysteamine
-
-
D-glucose
-
treatment with 0.025-0.035 mM H2O2, 4-8 mM acetoacetate and high D-glucose of 25 mM causes a significant decrease in enzyme protein expression, enzyme activity, and H2S levels, and an increase in intracellular reactive oxygen species production compared with those in normal controls
dichloro-D,L-Ala
-
-
DL-Penicillamine
-
3% residual activity at 5 mM
DL-propargylalanine
-
-
DL-propargylglycine
EDTA
-
2 mM, 13% inhibition
Fe2+
-
0.1 mM, weak
Fe3+
-
0.1 mM, weak
Gly
-
competitive
H2O2
-
treatment with 0.025-0.035 mM H2O2, 4-8 mM acetoacetate and high D-glucose of 25 mM causes a significant decrease in enzyme protein expression, enzyme activity, and H2S levels, and an increase in intracellular reactive oxygen species production compared with those in normal controls
HgCl2
-
a potent irreversible enzyme inhibitor, but HgCl2 is also a strong inactivator of cystathionine gamma-lyase
hydroxylamine
iodoacetamide
-
22% residual activity at 2.5 mM
Iodosobenzoate
-
-
Isoniazid
-
-
Isonicotinic acid hydrazide
-
-
L-aminoethoxyvinylglycine
-
-
L-Asn
-
weak
L-beta-oxalyl amino-L-alanine
-
inhibition only after long exposure
L-cysteine
L-Met
-
weak
L-Propargylglycine
-
-
L-Thr
-
weak
L-Val
-
weak
Mercurials
-
-
-
Mg2+
-
0.1 mM, weak
Mn2+
-
0.1 mM, weak
N-ethylmaleimide
N-prop-2-yn-1-ylglycine
-
-
NEM
-
0.05 mM, inhibition is partly relieved by 0.2 mM 2,3-dimercaptopropanol
NH4Cl/NH4OH buffer
-
-
-
Ni2+
-
0.1 mM, weak
O2
-
homogenized gills produces H2S enzymatically, and H2S production is inhibited by O2, whereas mitchondrial H2S consumption is O2 dependent
Penicillamine
phenylhydrazine
propargyl glycine
-
-
propargylglycine
Semicarbazide
Ser
-
competitive
Sodium bisulfite
-
-
Sodium borohydride
-
-
Sodium cyanide
-
alpha,beta-elimination, 1 mM, 82% inhibition
streptozotocin
-
livers from streptozotocin-treated type I diabetic rats have lower levels of enzyme protein expression, enzyme activity, reduced tissue H2S formation, and increased reactive oxygen species production compared with those of controls
trifluoro-Ala
trifluoroalanine
-
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(S)-propargyl-cysteine
-
(S)-propargyl-cysteine increases CSE activity by 1.6fold in myocardial infarction rats
2-mercaptoethanol
-
increases activity
calcium-calmodulin
-
catalytic activity of pure CSE is increased more than 2fold by calcium and calmodulin, but not by either substance alone
-
CYS3
a bZIP transcriptional activator, is the key regulator and necessary for regulation expression of the sulfur-related genes, binds on a consensus sequence for CYS3 binding
-
L-cysteine
low concentration of cellular cysteine leads to elevation of cystathionine gamma-lyase
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.153 - 1.417
(DL)-homocysteine
28.41
3-chloro-DL-alanine
-
pH 8.0, 37C
2.39
beta-chloro-L-Ala
-
-
0.1 - 3.2
beta-chloro-L-alanine
1
cystathionine
-
-
0.76 - 25.3
D-alanine
3.27
DL-cystathionine
-
pH 8.0, 37C
0.209
DL-lanthionine
-
-
5.18
DL-vinylglycine
-
-
1 - 20
L-alanine
0.029 - 0.069
L-Cys
0.204 - 25.5
L-cystathionine
0.09 - 7.7
L-cysteine
0.032 - 1.29
L-cystine
5.4 - 8
L-homocysteine
12.5
L-homoserine
-
-
0.39
Lanthionine
-
-
0.12
meso-cystine
-
-
0.7 - 5.3
O-acetyl-L-serine
2.75
S-(2-aminoethyl)-L-cysteine
-
pH 8.0, 37C
13.13
S-methyl-L-cysteine
-
pH 8.0, 37C
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12
Cys
Treponema denticola
-
-
1.9
cystathionine
Homo sapiens
-
-
0.02 - 7.5
L-cystathionine
0.029 - 1.44
L-cysteine
0.82 - 3.7
L-homocysteine
0.0035 - 0.0142
O-acetyl-L-serine
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0037 - 4.3
L-cystathionine
0.06 - 1.7
L-cysteine
0.0016 - 0.01
O-acetyl-L-serine
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
-
inhibition kinetics, overview
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0011
aminooxyacetic acid
Escherichia coli
-
pH 8.2, 37C
0.014
Beta-cyanoalanine
Escherichia coli
-
pH 8.2, 37C
0.065
DL-propargylglycine
Leishmania major
E9AFE7
pH 7.4, 37C
0.0048
hydroxylamine
Escherichia coli
-
pH 8.2, 37C
0.001
L-aminoethoxyvinylglycine
Escherichia coli
-
pH 8.2, 37C
0.04
propargylglycine
Escherichia coli
-
pH 8.2, 37C
0.289
trifluoroalanine
Escherichia coli
-
pH 8.2, 37C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
11.5
substrate cystathionine
24
-
purified liver enzyme, pH 7.4, 37C
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2 - 7.8
-
wild-type enzyme
8.9
-
Tris-HCl
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 8.5
-
pH 5.0: about 60% of maximal activity, pH 8.5: about 55% of maximal activity
5
-
20% residual activity
6
-
40% residual activity
6.5 - 8.5
-
pH 6.5: about 20% of maximal activity, pH 8.5: about 70% of maximal activity. No activity below pH 5.0 and above pH 9
6.5
-
substrate cystathionine, no activity below
8 - 9
-
pH 8.0: about 85% of maximal activity, pH 9.0: about 50% of maximal activity
9
-
90% residual activity
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
0.1 M potassium phosphate buffer
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 40
-
10C: about 35% of maximal activity, 40C: rapid decrease of activity above
30 - 55
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0.1 M potassium phosphate buffer, pH 7.8, 0.2 mM pyridoxal-5'-phosphate and 1 mM EDTA
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5
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isoelectric focusing
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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expression of both cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase, the activity of 3-mercaptopyruvate sulfurtransferase is higher than that of cystathionine gamma-lyase
Manually annotated by BRENDA team
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mainly expressed in airway and vascular smooth muscle cells in rat lung tissue
Manually annotated by BRENDA team
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cultured human aorta smooth muscle cell
Manually annotated by BRENDA team
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enzyme expression in numerous oval or polygonal cells
Manually annotated by BRENDA team
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whole cells, cell lysate of a culture broth, cell wall of a subcellular fraction
Manually annotated by BRENDA team
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high expression in cerebral organs and in the epithelium of the lateral cephalic slits through which these organs open to the outside, highest in the cerebral organs in the cells lining the inner channel and also in the rear cluster of neuro-glandular cells
Manually annotated by BRENDA team
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of the canals of the cerebral organs, enzyme expression
Manually annotated by BRENDA team
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CSE is localized in the muscular trabeculae and the smooth-muscle component of the penile artery
Manually annotated by BRENDA team
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only in the anterior- and the postero-lateral areas of the body
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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order of hydrogen sulfide production rates for different tissues are: liver (777 nM/min/g), followed by uterus (168 nM/min/g), fetal membranes (22.3 nM/min/g), placenta (11.1 nM/min/g), compared to human placenta (200 nM/min/g)
Manually annotated by BRENDA team