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4.4.1.1: cystathionine gamma-lyase

This is an abbreviated version!
For detailed information about cystathionine gamma-lyase, go to the full flat file.

Word Map on EC 4.4.1.1

Reaction

2-aminobut-2-enoate
=
2-iminobutanoate

Synonyms

AFUA_8G04340, C-S-lyase, C-S-lyase1, C-S-lyase2, C-S-lyase3, C-S-lyase4, cgl, CGL like protein, CS-LIKE, CSE, CSEgamma, CTH, CTT, cystalysin, cystathionase, cystathioninase, cystathionine beta/gamma-lyase, cystathionine gamma lyase, cystathionine gamma-lyase, cystathionine gamma-lyase-like protein, cystathionine-gamma-lyase, cysteine desulfhydrase, cysteine lyase, cystine desulfhydrase, dehydratase, homoserine, DES1, desulfhydrase, cysteine, EC 4.2.1.15, gamma-CTL, gamma-CTLase, gamma-cystathionase, hCSE, homoserine deaminase, homoserine deaminase-cystathionase, homoserine dehydratase, human cystathionine-gamma-lyase, L-Cys desulfhydrase, L-cysteine desulfhydrase, L-cysteine desulphydrase, L-cysteine-desulfhydrase, LCD, lyase, cystathionine gamma-, PRB-RA, Probasin-related antigen, TGME49_112930, XometC, yCGL

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.1 cystathionine gamma-lyase

Expression

Expression on EC 4.4.1.1 - cystathionine gamma-lyase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
0.001 mg/ml lipopolysaccharide stimulates the CSE mRNA and protein levels 2.5fold, L-arginine (0.1-1 mM) dose-dependently enhances CSE mRNA and protein expression in lipopolysaccharide-treated primary macrophages
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aortas from atherogenic apolipoprotein E knockout mice fed a high-fat diet show reduced CSEgamma mRNA expression and protein abundance
butyrate significantly increases CSE protein expression
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butyrate upregulates CSE expression
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cobalt-60 gamma radiation at doses of 14 Gy and 25 Gy decrease the cystathionine-gamma-lyase activity by 15.1% and 20.5%, respectively, and cystathionine-gamma-lyase mRNA expression by 29.3% and 38.2%, respectively
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CSE activity and protein levels in the colonic tissue do not notably change in the mice with colitis
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CSE expression and H2S production are increased during adipocyte differentiation, and the pattern of CSE mRNA expression is similar to that of CCAAT/enhancer-binding protein C/EBPbeta and C/EBPdelta, key regulators for adipogenesis. C/EBPbeta and gamma bind to the CCAAT box in CSE promoter and stimulate CSE gene transcription
CSE expression is significantly downregulated in patients with chronic kidney disease
CSE expression s lower, by 15.8%, 19.5% and 23.2%, following 24 h treatment with 0.1, 1 and 10 ng/ml transforming growth factor-beta1
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CSE mRNA and protein expression are upregulated by S-propargyl-cysteine
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CSEgamma expression is upregulated by pan-histone deacetylase inhibitors and by class II-specific HDAC inhibitors, but not by other class-specific inhibitors. The histone deacetylase 6 selective inhibitor tubacin and histone deacetylase 6-specific siRNA increase CSEgamma expression and block oxidized LDL-mediated reductions in endothelial CSEgamma expression and CSEgamma promoter activity
cys-16+ transcript levels in a activator/regulator CYS3-defective DELTAcys-3 regulatory mutant are present at a low level under either derepressing or repressing conditions
dexamethasone (0.001 mM) causes an about 85% decrease in CSE mRNA and 95% decrease in CSE protein levels, 1 mM NG-nitro-L-arginine methyl ester decreases lipopolysaccharide-induced CSE expression in macrophages
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either the activity or protein expression of pancreatic CSE increase after the development of caerulein-induced pancreatitis in mice
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enzyme expression levels are present only at a low level under sulfur sufficient (repressing) conditions
enzyme expression levels increase under sulfur limiting (derepressing) conditions
glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase. Expression of cystathionine-gamma-lyase is 1.5fold increased following incubation of the cells with diethylmaleate for 3 h. Co-incubation of C6 cells with diethylmaleate and the JNK-inhibitor, SP600125, abolishes the increase in expression of cystathionine-gamma-lyase that is observed in the presence of diethylmaleate alone
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H2S fumigation stimulates the expression of drought associated genes. The enzyme is strongly induced by drought stress, with a maximum accumulation after 6 h, overview
higher rate of H2S production corresponds to an up-regulation of CSE expression in liver and kidney
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human aortic endothelial cells exposed to oxidized LDL show reduced CSEgamma mRNA expression and protein abundance
livers from streptozotocin-treated type I diabetic rats have lower levels of enzyme protein expression, enzyme activity, reduced tissue H2S formation, and increased reactive oxygen species production compared with those of controls
mice that undergo 30 min of renal ischaemia and 24 h of reperfusion exhibit a significant increase in the expression of cystathionine gamma-lyase protein in the kidney
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presence of homocysteine upregulates cystathionine gamma lyase but downregulates cystathionine beta synthase whereas H2S-donor Na2S/GYY4137 downregulates cystathionine gamma lyase but upregulates cystathionine beta. The Na2S-treatment downregulates specificity protein-1, an inducer for cystathionine gamma lyase, and upregulates microRNA miR-133a that targets specificity protein-1, and inhibits cardiomyocytes hypertrophy. In the homocysteine-treated cardiomyocytes, cystathionine beta synthase and miR-133a are downregulated and hypertrophy is induced
serum deprivation induces smooth muscle cell differentiation marker gene expressions and increases CSE expression and H2S production. The region between -226 to +140 base pair contains the core promoter for the CSE gene
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the enzyme expression levels gradually increases in an age-dependent manner
the expression level and activity of cystathionine gamma-lyase is significantly decreased by methylglyoxal treatment (0.01-0.05 mM)
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the expression of CSE is increased by NaHS
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the level of CSE mRNA expression in liver are increased by hepatic ischemia-reperfusion
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