4.2.1.20: tryptophan synthase
This is an abbreviated version!
For detailed information about tryptophan synthase, go to the full flat file.
Word Map on EC 4.2.1.20
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4.2.1.20
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pain
-
pyridoxal
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typhimurium
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myofascial
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alpha-subunits
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beta-subunits
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5'-phosphate
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aldimine
-
vanilloid
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indole-3-glycerol
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trapezius
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nociceptive
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nose
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cone-shaped
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melastatin
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palpation
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bienzyme
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epiphyses
-
quinonoid
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craniofacial
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miles
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pear-shaped
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tension-type
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polycystin
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sternocleidomastoid
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beta-site
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tryptophanase
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l-trp
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urea-induced
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temporalis
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suboccipital
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metacarpal
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bulbous
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phalanx
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tryptophanyl-trna
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taut
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assessor
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scapula
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chaffeensis
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indoline
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ehrlichia
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levator
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5'-phosphate-dependent
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eyebrows
-
masseter
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dimethylallyl
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trpcs
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capitis
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exostoses
-
polymodal
-
biotechnology
-
synthesis
-
analysis
- 4.2.1.20
- pain
- pyridoxal
- typhimurium
-
myofascial
- alpha-subunits
- beta-subunits
- 5'-phosphate
-
aldimine
-
vanilloid
-
indole-3-glycerol
-
trapezius
-
nociceptive
-
nose
-
cone-shaped
-
melastatin
-
palpation
-
bienzyme
-
epiphyses
-
quinonoid
-
craniofacial
- miles
-
pear-shaped
-
tension-type
-
polycystin
-
sternocleidomastoid
-
beta-site
- tryptophanase
- l-trp
-
urea-induced
-
temporalis
-
suboccipital
-
metacarpal
-
bulbous
-
phalanx
-
tryptophanyl-trna
-
taut
- assessor
-
scapula
- chaffeensis
- indoline
- ehrlichia
-
levator
-
5'-phosphate-dependent
-
eyebrows
-
masseter
-
dimethylallyl
-
trpcs
-
capitis
- exostoses
-
polymodal
- biotechnology
- synthesis
- analysis
Reaction
Synonyms
alpha2beta2 tryptophan synthase, alphaTS, AtTSB1, beta subunit of tryptophan synthase, indoleglycerol phosphate aldolase, It-TSA, L-serine hydro-lyase (adding indoleglycerol-phosphate), L-tryptophan synthetase, PtTSA, Rv1612, synthase, tryptophan, TrB, Trp synthase, Trp synthase beta, TrpA, trpB, TrpB1, TrpB2, TrpB2a, TrpB2i, TrpB2o, TRPS, tryptophan desmolase, tryptophan synthase, tryptophan synthase alpha subunit, tryptophan synthase alpha-subunit, tryptophan synthase alpha2beta2 complex, tryptophan synthase beta, tryptophan synthase beta 1, tryptophan synthase beta subunit, tryptophan synthetase, TS, TSA, TSase, TSB, TSB1, TSbeta
ECTree
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KM Value
KM Value on EC 4.2.1.20 - tryptophan synthase
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1.1
D-glyceraldehyde 3-phosphate
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cosubstrate L-Trp, i.e. reverse reaction
0.02
serine
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serine deaminase reaction
0.01
-
reaction of alpha2beta2 complex
0.04
1-(indol-3-yl)glycerol 3-phosphate
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reaction of alpha subunit
0.19
1-(indol-3-yl)glycerol 3-phosphate
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pH 7.5, 80°C, recombinant (TrpA-TrpB1)2 tetrameric complex, alpha-reaction
1.62
1-(indol-3-yl)glycerol 3-phosphate
-
pH 7.5, 80°C, recombinant TrpA, alpha-reaction
0.02
cosubstrate L-serine, pH 8.0, temperature not specified in the publication
1.4
1-C-(indol-3-yl)glycerol 3-phosphate
cosubstrate L-threonine, pH 8.0, temperature not specified in the publication
0.0076
indole
pH 7.5, 85°C, reaction catalyzed by TrpB2 in presence of subunit TrpA
0.0081
indole
pH 7.5, 85°C, reaction catalyzed by TrpB1
0.009
indole
mutant P12L/E17G/I68V/F274S/T292S/T321A, pH 8.0, 75°C
0.018
indole
-
cosubstrate L-Ser, presence of 20 mM Na+
0.025
indole
-
pH 7.5, 80°C, recombinant (TrpA-TrpB1)2 tetrameric complex, beta-reaction
0.035
indole
pH 7.5, 85°C, reaction catalyzed by TrpB1 in presence of subunit TrpA
0.035
indole
pH 7.5, 85°C, he reaction is catalyzed by TrpB1
0.044
indole
-
cosubstrate L-Ser, presence of 20 mM Li+
0.048
indole
mutant P25L/P30G/I80V/L285S/T303S/T321A, pH 8.0, 60°C
0.0629
indole
pH 7.5, 85°C, reaction catalyzed by TrpB2
0.0629
indole
pH 7.5, 85°C, the reaction is catalyzed by the complex of TrpB1 and TrpA
0.067
indole
-
cosubstrate L-Ser, presence of 20 mM Cs+
0.094
indole
-
37°C, beta-replacement, enzyme in solution
0.095
indole
-
cosubstrate L-Ser, presence of 20 mM K+
0.15
indole
-
37°C, beta-replacement, enzyme encapsulated in tetramethylorthosilicate-derived wet silica gels
8.7
indole
subunit TrpB1, mutant P12L/E17G/I68V/F274S/T292S/T321A, pH 8.0, 75°C
11
indole
subunit TrpB1, mutant E17G/I68V/F274S/T292S/T321A, pH 8.0, 75°C
0.0076
subunit TrpB2 plus subunit TrpA, at pH 7.5 and 85°C
0.0081
L-serine
subunit TrpB2, at pH 7.5 and 85°C
0.035
L-serine
subunit TrpB1 plus subunit TrpA, at pH 7.5 and 85°C
0.14
L-serine
-
in the presence of 250 mM NaCl, at pH 8.5 and 25°C
0.27
L-serine
-
in the presence of 100 mM KCl, at pH 8.5 and 25°C
0.52
L-serine
-
in the presence of 250 mM NaCl, at pH 7.8 and 25°C
0.58
L-serine
-
in the presence of 100 mM KCl, at pH 7.8 and 25°C
0.629
L-serine
subunit TrpB1, at pH 7.5 and 85°C
0.7
L-serine
subunit TrpB1, mutant P12L/E17G/I68V/F274S/T292S/T321A, pH 8.0, 75°C
0.98
L-serine
-
37°C, beta-replacement, enzyme in solution
1.16
L-serine
-
37°C, beta-elimination, enzyme in solution
1.17
L-serine
-
37°C, beta-replacement, enzyme encapsulated in tetramethylorthosilicate-derived wet silica gels
1.2
L-serine
subunit TrpB1, mutant E17G/I68V/F274S/T292S/T321A, pH 8.0, 75°C
1.4
L-serine
-
mutant L166V, pH not specified in the publication, temperature not specified in the publication
1.41
L-serine
-
37°C, beta-elimination, enzyme encapsulated in tetramethylorthosilicate-derived wet silica gels
1.6
L-serine
-
without monovalent cations, at pH 6.5 and 25°C
1.6
L-serine
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without monovalent cations, at pH 7.8 and 25°C
1.6
L-serine
-
wild-type, pH not specified in the publication, temperature not specified in the publication
1.89
L-serine
-
in the presence of 100 mM KCl, at pH 6.5 and 25°C
1.9
L-serine
-
in the presence of 100 mM CsCl, at pH 8.5 and 25°C
2.7
L-serine
-
without monovalent cations, at pH 8.5 and 25°C
3.7
L-serine
-
pH 7.5, 80°C, recombinant (TrpA-TrpB1)2 tetrameric complex, beta-reaction
4.78
L-serine
-
in the presence of 250 mM NaCl, at pH 6.5 and 25°C
5.6
L-serine
-
in the presence of 100 mM CsCl, at pH 7.8 and 25°C
9
L-serine
-
in the presence of 100 mM CsCl, at pH 6.5 and 25°C
52
L-serine
-
mutant L166A, pH not specified in the publication, temperature not specified in the publication
1.3
pH 8.0, temperature not specified in the publication
210
L-threonine
-
wild-type, pH not specified in the publication, temperature not specified in the publication
310
L-threonine
-
mutant L166V, pH not specified in the publication, temperature not specified in the publication
340
L-threonine
-
mutant L166A, pH not specified in the publication, temperature not specified in the publication
additional information
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kinetics
-
additional information
additional information
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kinetics
-
additional information
additional information
-
dissociation constants of the beta-subunit combined with the different subunits of wild-type and mutants
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additional information
additional information
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dissociation constants, kinetics
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additional information
additional information
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kinetic isotope effects with alpha-2H-L-Ser, and thermodynamics, wild-type and mutant
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additional information
additional information
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kinetics and temperature-dependence
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additional information
additional information
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kinetics for the wild-type and channel-impaired mutants
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additional information
additional information
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kinetics of formation of quinoid reaction intermediates in the beta-active site upon reaction with the substrates, pH-dependence
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additional information
additional information
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kinetics of proton release during beta-reaction, thermodynamic cycle of the interconversion of L-serine and alpha-aminoacrylate intermediate structures
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additional information
additional information
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kinetics of the hydrogen-deuterium exchange reactions
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additional information
additional information
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kinetics of wild-type enzyme complex and mutant betaA169L/betaC170W
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additional information
additional information
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kinetics, beta-reaction
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additional information
additional information
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kinetics, temperature-, and pH-dependence, and isotope effect at pH 7.0, not at pH 9.0, overview
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additional information
additional information
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kinetics, wild-type and mutant H86L enzymes
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additional information
additional information
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kinetics, wild-type and mutants, isotope effects and effector influence
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additional information
additional information
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thermodynamic parameters of subunit association, kinetics
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