4.2.1.20: tryptophan synthase
This is an abbreviated version!
For detailed information about tryptophan synthase, go to the full flat file.
Word Map on EC 4.2.1.20
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4.2.1.20
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pain
-
pyridoxal
-
typhimurium
-
myofascial
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alpha-subunits
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beta-subunits
-
5'-phosphate
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aldimine
-
vanilloid
-
indole-3-glycerol
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trapezius
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nociceptive
-
nose
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cone-shaped
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melastatin
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palpation
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bienzyme
-
epiphyses
-
quinonoid
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craniofacial
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miles
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pear-shaped
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tension-type
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polycystin
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sternocleidomastoid
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beta-site
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tryptophanase
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l-trp
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urea-induced
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temporalis
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suboccipital
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metacarpal
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bulbous
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phalanx
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tryptophanyl-trna
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taut
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assessor
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scapula
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chaffeensis
-
indoline
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ehrlichia
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levator
-
5'-phosphate-dependent
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eyebrows
-
masseter
-
dimethylallyl
-
trpcs
-
capitis
-
exostoses
-
polymodal
-
biotechnology
-
synthesis
-
analysis
- 4.2.1.20
- pain
- pyridoxal
- typhimurium
-
myofascial
- alpha-subunits
- beta-subunits
- 5'-phosphate
-
aldimine
-
vanilloid
-
indole-3-glycerol
-
trapezius
-
nociceptive
-
nose
-
cone-shaped
-
melastatin
-
palpation
-
bienzyme
-
epiphyses
-
quinonoid
-
craniofacial
- miles
-
pear-shaped
-
tension-type
-
polycystin
-
sternocleidomastoid
-
beta-site
- tryptophanase
- l-trp
-
urea-induced
-
temporalis
-
suboccipital
-
metacarpal
-
bulbous
-
phalanx
-
tryptophanyl-trna
-
taut
- assessor
-
scapula
- chaffeensis
- indoline
- ehrlichia
-
levator
-
5'-phosphate-dependent
-
eyebrows
-
masseter
-
dimethylallyl
-
trpcs
-
capitis
- exostoses
-
polymodal
- biotechnology
- synthesis
- analysis
Reaction
Synonyms
alpha2beta2 tryptophan synthase, alphaTS, AtTSB1, beta subunit of tryptophan synthase, indoleglycerol phosphate aldolase, It-TSA, L-serine hydro-lyase (adding indoleglycerol-phosphate), L-tryptophan synthetase, PtTSA, Rv1612, synthase, tryptophan, TrB, Trp synthase, Trp synthase beta, TrpA, trpB, TrpB1, TrpB2, TrpB2a, TrpB2i, TrpB2o, TRPS, tryptophan desmolase, tryptophan synthase, tryptophan synthase alpha subunit, tryptophan synthase alpha-subunit, tryptophan synthase alpha2beta2 complex, tryptophan synthase beta, tryptophan synthase beta 1, tryptophan synthase beta subunit, tryptophan synthetase, TS, TSA, TSase, TSB, TSB1, TSbeta
ECTree
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Metals Ions
Metals Ions on EC 4.2.1.20 - tryptophan synthase
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Cd2+
enzyme is up-regulated in plants treated with Cd2+. Overexpression in Arabidopsis and Solanum lycopersicum confers tolerance to cadmium stress
Cs+
DL-glycerol 3-phosphate
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enhances beta-reaction activity of mutant D305N and K167T
K+
Li+
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has an effect on the conformational equilibrium
Na+
NaCl
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ligand binding sites, effector on the action of activators or inhibitors, overview
NH4+
Rb+
-
has an effect on the conformational equilibrium
additional information
Cs+
-
activates the wild-type enzyme and mutant D305A
Cs+
-
activation of mutants D56A and K167T
Cs+
-
affects kinetic properties of the enzyme complex and stabilizes the quinoid intermediates formed
Cs+
-
involved in the thermal stability and activity equilibrium of the enzyme complex, overview
Cs+
-
has an effect on the conformational equilibrium
Cs+
-
the enzyme contains three Cs+ ions
K+
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enhances beta-reaction activity of wild-type and mutants, except for mutant D56A
K+
-
monovalent cations are effectors of the 2-step beta-reaction, role in reaction equilibrium and rate-limitation, overview
K+
-
has an effect on the conformational equilibrium
Na+
-
affects kinetic properties of the enzyme complex and stabilizes the quinoid intermediates formed
Na+
-
enhances beta-reaction activity of wild-type
Na+
-
involved in the thermal stability and activity equilibrium of the enzyme complex, overview
Na+
-
monovalent cations are effectors of the 2-step beta-reaction, role in reaction equilibrium and rate-limitation, overview
Na+
-
has an effect on the conformational equilibrium
Na+
-
in the presence of 100 mM NaCl the enzyme keeps in the Na+ activated form
NH4+
-
activates the wild-type enzyme and mutant D305A
NH4+
-
enhances beta-reaction activity of all wild-type and mutants
NH4+
-
has little effect on the conformational equilibrium
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the enzyme shows high tolerance to ammonium chloride from hair acid hydrolysis industries waste water, and shows no inhibition by ammonium chloride up to 75 mg/ml
additional information
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effects of Na+ and Cs+ in the intermediate formation between L-serine and aniline
additional information
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monovalent cations are involved in the thermal stability and activity equilibrium of the enzyme complex, overview
additional information
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the beta-reaction is influenced by protons, monovalent cations, and alpha-subunit ligands, that modulate the distribution between open and closed conformation
additional information
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without a bound monovalent cation both the reaction of indoline with alpha-aminoacrylate Schiff base species E(A-A) and the reaction with L-His with internal aldimine Schiff base species are strongly impaired. Monovalent cation binding ensures the structural integrity needed by the beta-active site during stage II of the beta-reaction