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4.2.1.20: tryptophan synthase

This is an abbreviated version!
For detailed information about tryptophan synthase, go to the full flat file.

Word Map on EC 4.2.1.20

Reaction

1-C-(indol-3-yl)glycerol 3-phosphate
=
indole
 +
D-glyceraldehyde 3-phosphate

Synonyms

alpha2beta2 tryptophan synthase, alphaTS, AtTSB1, beta subunit of tryptophan synthase, indoleglycerol phosphate aldolase, It-TSA, L-serine hydro-lyase (adding indoleglycerol-phosphate), L-tryptophan synthetase, PtTSA, Rv1612, synthase, tryptophan, TrB, Trp synthase, Trp synthase beta, TrpA, trpB, TrpB1, TrpB2, TrpB2a, TrpB2i, TrpB2o, TRPS, tryptophan desmolase, tryptophan synthase, tryptophan synthase alpha subunit, tryptophan synthase alpha-subunit, tryptophan synthase alpha2beta2 complex, tryptophan synthase beta, tryptophan synthase beta 1, tryptophan synthase beta subunit, tryptophan synthetase, TS, TSA, TSase, TSB, TSB1, TSbeta

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.20 tryptophan synthase

Substrates Products

Substrates Products on EC 4.2.1.20 - tryptophan synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine
L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
show the reaction diagram
(3S)-2,3-dihydro-5-fluoro-L-tryptophan
?
show the reaction diagram
-
isomerization
-
-
?
1-(indol-3-yl)glycerol 3-phosphate
D-glyceraldehyde 3-phosphate + indole
show the reaction diagram
1-(indol-3-yl)glycerol 3-phosphate + L-serine
L-tryptophan + D-glyceraldehyde 3-phosphate
show the reaction diagram
1-(indol-3-yl)glycerol 3-phosphate + L-serine
L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
show the reaction diagram
1-C-(indol-3-yl)glycerol 3-phosphate
D-glyceraldehyde 3-phosphate + indole
show the reaction diagram
2-amino-3-butenoic acid
2-oxobutyric acid + NH3
show the reaction diagram
2-mercaptoethanol + L-serine + pyridoxal phosphate
S-pyruvylmercaptoethanol + pyridoxamine phosphate + H2O
show the reaction diagram
5-fluoro-L-tryptophan
?
show the reaction diagram
-
isomerization
-
-
?
beta-chloro-L-alanine
pyruvate + NH3 + HCl
show the reaction diagram
-
in absence of indole
-
?
beta-chloro-L-alanine + indole
L-tryptophan + HCl
show the reaction diagram
-
-
-
?
D-glyceraldehyde 3-phosphate + indole
1-(indol-3-yl)glycerol 3-phosphate
show the reaction diagram
-
-
-
?
indole + D-glyceraldehyde 3-phosphate
indole-3-glycerol phosphate
show the reaction diagram
indole + L-serine
L-tryptophan + H2O
show the reaction diagram
indole-3-glycerol phosphate
indole + D-glyceraldehyde 3-phosphate
show the reaction diagram
indoleglycerol phosphate
indole + D-glyceraldehyde 3-phosphate
show the reaction diagram
the reaction is catalyzed by the tryptophan synthase alpha-subunit TrpA
-
-
r
indoline + L-serine
dihydroisotryptophan + H2O
show the reaction diagram
-
monovalent cation-bound alpha-aminoacrylate Schiff base species E(A-A) reacts rapidly with indoline to give the indoline quinonoid species, E(Q)indoline, which slowly converts to dihydroiso-L-tryptophan
-
-
?
L-histidine + L-serine
?
show the reaction diagram
-
reaction of L-His with internal aldimine species gives an equilibrating mixture of external aldimine and quinonoid species, E(Aex)his and E(Q)his
-
-
?
L-Ser + indole
L-tryptophan + H2O
show the reaction diagram
-
reaction catalyzed by the beta subunit
-
-
ir
L-serine
pyruvate + NH3
show the reaction diagram
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate
L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
show the reaction diagram
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate
L-tryptophan + glyceraldehyde 3-phosphate + H2O
show the reaction diagram
L-serine + 1H-indole-5-carbaldehyde
5-formyl-L-tryptophan + H2O
show the reaction diagram
L-serine + 2-methylindole
2-methyltryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 2-methylindole
L-2-methyltryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 4-bromoindole
4-bromotryptophan + H2O
show the reaction diagram
L-serine + 4-hydroxyindole
4-hydroxytryptophan + H2O
show the reaction diagram
-
-
-
?
L-serine + 4-methylindole
4-methyltryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 5-bromoindole
5-bromo-L-tryptophan + H2O
show the reaction diagram
L-serine + 5-bromoindole
5-bromotryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 5-chloroindole
5-chloro-L-tryptophan + H2O
show the reaction diagram
L-serine + 5-chloroindole
5-chlorotryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 5-cyanoindole
5-cyano-L-tryptophan + H2O
show the reaction diagram
substrate of mutant M145T/N167D, 49% yield
-
-
?
L-serine + 5-fluoroindole
5-fluorotryptophan + H2O
show the reaction diagram
L-serine + 5-hydroxyindole
5-hydroxy-L-tryptophan + H2O
show the reaction diagram
L-serine + 5-hydroxyindole
5-hydroxytryptophan + H2O
show the reaction diagram
-
-
-
?
L-serine + 5-methoxyindole
5-methoxy-L-tryptophan + H2O
show the reaction diagram
L-serine + 5-methylindole
5-methyl-L-tryptophan + H2O
show the reaction diagram
L-serine + 5-methylindole
5-methyltryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 5-nitroindole
5-nitro-L-tryptophan + H2O
show the reaction diagram
L-serine + 6-bromoindole
6-bromotryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 6-chloroindole
6-chlorotryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 6-fluoroindole
6-fluorotryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 6-methylindole
6-methyltryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 7-bromoindole
7-bromotryptophan + H2O
show the reaction diagram
L-serine + 7-chloroindole
7-chlorotryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + 7-fluoroindole
7-fluorotryptophan + H2O
show the reaction diagram
L-serine + 7-hydroxyindole
7-hydroxytryptophan + H2O
show the reaction diagram
-
-
-
?
L-serine + 7-methylindole
7-methyltryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-serine + indole
L-tryptophan + H2O
show the reaction diagram
L-serine + indole
tryptophan + H2O
show the reaction diagram
L-serine + indoline
dihydro-iso-L-tryptophan + H2O
show the reaction diagram
-
-
i.e. DIT
?
L-serine + indoline
dihydroiso-L-tryptophan
show the reaction diagram
-
wild-type and mutant D305A enzymes
-
?
L-serine + indoline
dihydroiso-L-tryptophan + H2O
show the reaction diagram
-
-
i.e. DIT
?
L-serine + N-(4'-trifluoromethoxybenzenesulfonyl)-2-aminoethyl phosphate
?
show the reaction diagram
-
-
-
-
?
L-serine + N-(4'-trifluoromethoxybenzoyl)-2-aminoethyl phosphate
?
show the reaction diagram
-
-
-
-
?
L-serine + thiophenol
(S)-phenyl-L-cysteine + H2O
show the reaction diagram
-
-
-
-
?
L-threonine + 1-C-(indol-3-yl)glycerol 3-phosphate
(2S,3S)-beta-methyltryptophan + D-glyceraldehyde 3-phosphate + H2O
show the reaction diagram
L-threonine + 2-methylindole
2-methyl-(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
L-threonine + 4-fluoroindole
4-fluoro-(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
L-threonine + 4-methylindole
4-methyl-(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
L-threonine + 5-fluoroindole
5-fluoro-(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
reaction of mutant I16V/E17G/I68V/F95L/F274S/T292S/T321A/V384A
-
-
?
L-threonine + 6-methylindole
6-methyl-(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
L-threonine + 7-azaindole
7-aza-(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
reaction of mutant I16V/E17G/I68V/F95L/F274S/T292S/T321A/V384A
-
-
?
L-threonine + 7-chloroindole
7-chloro-(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-threonine + 7-fluoroindole
7-fluoro-(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-threonine + 7-methoxyindole
7-methoxy-(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-threonine + 7-methylindole
7-methyl-(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
-
-
-
-
?
L-threonine + indole
(2S,3S)-beta-methyltryptophan + H2O
show the reaction diagram
L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
indole-3-glycerol phosphate + L-serine
show the reaction diagram
-
r
r
?
O-phospho-L-serine + indole
L-tryptophan + phosphate
show the reaction diagram
serine + indole
tryptophan + H2O
show the reaction diagram
-
-
-
?
additional information
?
-