4.2.1.20: tryptophan synthase
This is an abbreviated version!
For detailed information about tryptophan synthase, go to the full flat file.
Word Map on EC 4.2.1.20
-
4.2.1.20
-
pain
-
pyridoxal
-
typhimurium
-
myofascial
-
alpha-subunits
-
beta-subunits
-
5'-phosphate
-
aldimine
-
vanilloid
-
indole-3-glycerol
-
trapezius
-
nociceptive
-
nose
-
cone-shaped
-
melastatin
-
palpation
-
bienzyme
-
epiphyses
-
quinonoid
-
craniofacial
-
miles
-
pear-shaped
-
tension-type
-
polycystin
-
sternocleidomastoid
-
beta-site
-
tryptophanase
-
l-trp
-
urea-induced
-
temporalis
-
suboccipital
-
metacarpal
-
bulbous
-
phalanx
-
tryptophanyl-trna
-
taut
-
assessor
-
scapula
-
chaffeensis
-
indoline
-
ehrlichia
-
levator
-
5'-phosphate-dependent
-
eyebrows
-
masseter
-
dimethylallyl
-
trpcs
-
capitis
-
exostoses
-
polymodal
-
biotechnology
-
synthesis
-
analysis
- 4.2.1.20
- pain
- pyridoxal
- typhimurium
-
myofascial
- alpha-subunits
- beta-subunits
- 5'-phosphate
-
aldimine
-
vanilloid
-
indole-3-glycerol
-
trapezius
-
nociceptive
-
nose
-
cone-shaped
-
melastatin
-
palpation
-
bienzyme
-
epiphyses
-
quinonoid
-
craniofacial
- miles
-
pear-shaped
-
tension-type
-
polycystin
-
sternocleidomastoid
-
beta-site
- tryptophanase
- l-trp
-
urea-induced
-
temporalis
-
suboccipital
-
metacarpal
-
bulbous
-
phalanx
-
tryptophanyl-trna
-
taut
- assessor
-
scapula
- chaffeensis
- indoline
- ehrlichia
-
levator
-
5'-phosphate-dependent
-
eyebrows
-
masseter
-
dimethylallyl
-
trpcs
-
capitis
- exostoses
-
polymodal
- biotechnology
- synthesis
- analysis
Reaction
Synonyms
alpha2beta2 tryptophan synthase, alphaTS, AtTSB1, beta subunit of tryptophan synthase, indoleglycerol phosphate aldolase, It-TSA, L-serine hydro-lyase (adding indoleglycerol-phosphate), L-tryptophan synthetase, PtTSA, Rv1612, synthase, tryptophan, TrB, Trp synthase, Trp synthase beta, TrpA, trpB, TrpB1, TrpB2, TrpB2a, TrpB2i, TrpB2o, TRPS, tryptophan desmolase, tryptophan synthase, tryptophan synthase alpha subunit, tryptophan synthase alpha-subunit, tryptophan synthase alpha2beta2 complex, tryptophan synthase beta, tryptophan synthase beta 1, tryptophan synthase beta subunit, tryptophan synthetase, TS, TSA, TSase, TSB, TSB1, TSbeta
ECTree
Advanced search results
Cofactor
Cofactor on EC 4.2.1.20 - tryptophan synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
-
-
pyridoxal 5'-phosphate
-
dependent on
pyridoxal 5'-phosphate
-
2 mol bound per mol of beta2 subunit
pyridoxal 5'-phosphate
-
forms a Schiff base with the epsilon amino-group of Lys87
pyridoxal 5'-phosphate
-
dependent on, bound to the enzyme
pyridoxal 5'-phosphate
-
dependent on, bound via Schiff base to beta-subunit residue Lys87
pyridoxal 5'-phosphate
-
dependent on, His86 is necessary for binding and stabilization in a correct orientation in the active site of the beta-subunit
pyridoxal 5'-phosphate
-
forms an alpha-aminoacrylate Schiffbase intermediate with L-serine
pyridoxal 5'-phosphate
crystal structures of apo-beta2 and holo-beta2 from Escherichia coli is determined at 3.0 and 2.9 A resolutions. The apo-type and holo-type molecule retain a dimeric form in solution. The subunit structures of both the apo-beta2 and the holo-beta2 forms consist of two domains, (N domain, C domain). The pyridoxal 5'-phosphate-bound holo-form has multiple interactions between the two domains and a long loop (residues 260-310), which are missing in the apo-form
pyridoxal 5'-phosphate
-
the coenzyme for reactions catalyzed at the active site of the beta-subunit
pyridoxal 5'-phosphate
in all intermediates, the unprotonated phosphoryl group with a formal -2 charge serves as the main anchor for the cofactor, maintaining important protein-substrate interactions and allowing for chemical transformations mediated by the functional groups of the PLP and substrates. The unprotonated pyridine nitrogen can form an H-bond with Ser377, which stabilizes the PLP ring structure
pyridoxal 5'-phosphate
residue Lys87 of the beta-subunit activates C4' of pyridoxal 5'-phosphate for substrate nucleophilic attack