Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glycine | competitive | Salmonella enterica subsp. enterica serovar Typhimurium | |
additional information | inhibition mechanism | Salmonella enterica subsp. enterica serovar Typhimurium | |
oxindolyl-L-alanine | competitive | Salmonella enterica subsp. enterica serovar Typhimurium |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics, temperature-, and pH-dependence, and isotope effect at pH 7.0, not at pH 9.0, overview | Salmonella enterica subsp. enterica serovar Typhimurium |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O | also catalyses the conversion of serine and indole into tryptophan and water, and of indoleglycerol phosphate into indole and glyceraldehyde phosphate (the latter reaction was listed formerly as EC 4.2.1.8), catalytic mechanism, allosteric ligand binding | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-(indol-3-yl)glycerol 3-phosphate + L-serine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | L-tryptophan + D-glyceraldehyde 3-phosphate | - |
? | |
serine + indole | - |
Salmonella enterica subsp. enterica serovar Typhimurium | tryptophan + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | alpha2beta2 complex | Salmonella enterica subsp. enterica serovar Typhimurium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | dependent on | Salmonella enterica subsp. enterica serovar Typhimurium |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
7.3 | - |
glycine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
7.3 | - |
oxindolyl-L-alanine | - |
Salmonella enterica subsp. enterica serovar Typhimurium |