Reference on EC 4.2.1.20 - tryptophan synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pratt, M.L.; DeMoss, J.A.
Neurospora tryptophan synthase. Characterization of the pyridoxal phosphate binding site
J. Biol. Chem.
263
6872-6876
1988
Neurospora crassa
Crawford, I.P.; Niermann, T.; Kirschner, K.
Prediction of secondary structure by evolutionary comparison: application to the alpha-subunit of tryptophan synthase
Proteins Struct. Funct. Genet.
2
118-129
1987
Klebsiella aerogenes, Bacillus subtilis, Corynebacterium glutamicum, Saccharomyces cerevisiae, Caulobacter vibrioides, Escherichia coli, Lacticaseibacillus casei, Neurospora crassa, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Vibrio parahaemolyticus
Miles, E.W.; Bauerle, R.; Ahmed S.A.
Tryptophan synthase from Escherichia coli and Salmonella thyphimurium
Methods Enzymol.
142
398-414
1987
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Yutani, K.; Ogasahara, K.; Tsujita, T.; Sugino, Y.
Dependence of conformational stability on hydrophobicity of the amino acid residue in a series of variant proteins substituted at a unique position of tryptophan synthase alpha subunit
Proc. Natl. Acad. Sci. USA
84
4441-4444
1987
Escherichia coli
Milton, D.L.; Napier, M.L.; Myers, R.M.; Hardman, J.K.
In vitro mutagensis and overexpression of the Escherichia coli trpA gene and the partial characterization of the resultant tryptophan synthase mutant alpha-subunits
J. Biol. Chem.
261
16604-16615
1986
Escherichia coli
Drewe, W.F.; Dunn, M.F.
Characterization of the reaction of L-serine and indole with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy
Biochemistry
25
2494-2501
1986
Escherichia coli
Bailey, C.J.; Turner, P.D.
Purification and properties of tryptophan synthase from baker's yeast (Saccharomyces cerevisiae)
Biochem. J.
209
151-157
1983
Saccharomyces cerevisiae
Bartholmes, P.; Boeker, H.; Jaenicke, R.
Purification of tryptophan synthase from Saccharomyces cerevisiae and partial activity of its nicked subunits
Eur. J. Biochem.
102
167-172
1979
Saccharomyces cerevisiae
Rocha, V.; Brennan, E.F.
Purification and partial characterization of the B subunit of Serratia marcescens tryptophan synthetase
J. Bacteriol.
134
950-957
1978
Serratia marcescens
Riverin, M.; Drapeau, G.R.
Purification and properties of the alpha2beta2 complex of tryptophan synthetase of Proteus mirabilis
J. Biol. Chem.
251
3875-3880
1976
Proteus mirabilis
Shannon, L.M.; Mills, S.E.
Purification and immunoadsorbtion chromatography of the normal and a mutant form of the B2 subunit of Escherichia coli tryptophan synthase
Eur. J. Biochem.
63
563-568
1976
Escherichia coli
Kirschner, K.; Wiskocil, R.L.; Foehn, M.; Rezeau, L.
The tryptophan synthase from Escherichia coli. An improved purification procedure for the alpha-subunit and binding studies with substrate analogues
Eur. J. Biochem.
60
513-523
1975
Escherichia coli
Wolf, D.H.; Hoffmann, M.
Tryptophan synthase from yeast. Purification by affinity chromatography, physical properties
Eur. J. Biochem.
45
269-276
1974
Saccharomyces cerevisiae
Owens, D.; Bailey, C.J.
The purification and structure of tryptohan synthetase from Neurospora crassa
Biochem. Soc. Trans.
2
1331-1332
1974
Neurospora crassa
-
Zaffaroni, P.; Vitobello, V.; Cecere, F.; Giacomozzi, E.; Morisi, F.
Synthesis of L-tryptophan from indole and DL-serine by tryptophan synthetase entrapped in fibres 1. Preparation and properties of free and entrapped enzyme
Agric. Biol. Chem.
38
1335-1342
1974
Escherichia coli
-
O'Neil Hoch, S.
Tryptophan synthetase from Bacillus subtilis, purification and characterization of the alpha component
J. Biol. Chem.
248
2999-3003
1973
Bacillus subtilis
O'Neil Hoch, S.
Tryptophan synthetase from Bacillus subtilis. Purification and characterization of the beta2 component
J. Biol. Chem.
248
2992-2998
1973
Bacillus subtilis
-
Tsai, H.; Suskind, S.R.
Enzymatic properties of a mutant tryptophan synthase from Neurospora crassa
Biochim. Biophys. Acta
284
324-340
1972
Neurospora crassa
Nagao, R.T.; Moore, T.C.
Partial purification and properties of tryptophan synthase of pea plants
Arch. Biochem. Biophys.
149
402-443
1972
Pisum sativum
Miles, E.W.
Tryptophan synthase, structure, function, and protein engineering
Subcell. Biochem.
24
207-254
1995
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Hyde, C.C.; Ahmed, S.A.; Padlan, E.A.; Miles, E.W.; Davies, D.R.
Three-dimensional structure of the tryptophan synthase alpha2beta2 multienzyme complex from Salmonella typhimurium
J. Biol. Chem.
263
17857-17871
1988
Salmonella enterica subsp. enterica serovar Typhimurium
Ahmed, S.A.; Hyde, C.C.; Thomas, G.; Miles, E.W.
Microcrystals of tryptophan synthase alpha2beta2 complex from Salmonella typhimurium are catalytically active
Biochemistry
26
5492-5498
1987
Salmonella enterica subsp. enterica serovar Typhimurium
Lane, A.N.; Paul, C.H.; Kirschner, K.
The mechanism of self-assembly of the multi-enzyme complex tryptophan synthase from Escherichia coli
EMBO J.
3
279-287
1984
Escherichia coli
Rekoslavskava, N.I.; Kuznetsova, E.V.; Vysotskaya, E.F.; Salyaec, R.K.
Tryptophan synthase from Agrobacterium tumefaciens 8628: isolation and properties
Biokhimiya
62
433-439
1997
Agrobacterium tumefaciens
Radwanski, E.R.; Barczak, A.J.; Last, R.L.
Characterization of tryptophan synthase alpha subunit mutants of Arabidopsis thaliana
Mol. Gen. Genet.
253
353-361
1996
Arabidopsis thaliana
Ahmed, S.A.; McPhie, P.; Miles, E.W.
A thermally induced reversible conformational transition of the tryptophan synthase beta2 subunit probed by the spectroscopic properties of pyridoxal phosphate and by enzymatic activity
J. Biol. Chem.
271
8612-8617
1996
Escherichia coli
Choi, S.G.; O'Donnell, S.E.; Sarken, K.D.; Hardmann, J.K.
Tryptophan-containing alpha-subunits of the Escherichia coli tryptophan synthase. Enzymatic and urea stability properties
J. Biol. Chem.
270
17712-17715
1995
Escherichia coli
Peracchi, A.; Mozzarelli, A.; Rosi, G.L.
Monovalent cations affect dynamic and functional properties of the tryptophan synthase alpha2beta2 complex
Biochemistry
34
9459-9465
1995
Salmonella enterica subsp. enterica serovar Typhimurium
Choi, S.G.; Hardmann, J.K.
Unfolding properties of tryptophan-containing alpha-subunits of the Escherichia coli tryptophan synthase
J. Biol. Chem.
270
28177-28182
1995
Escherichia coli
Anderson, K.S.; Kim, A.Y.; Quillen, J.M.; Sayers, E.; Yang, X.J.; Miles, E.W.
Kinetic characterization of channel impaired mutants of tryptophan synthase
J. Biol. Chem.
270
29936-29944
1995
Escherichia coli
Zhao, G.P.; Somerville, R.L.
Genetic and biochemical characterization of the trpB8 mutation of Escherichia coli tryptophan synthase. An amino acid switch at the sharp turn of the trypsin-sensitive hinge region diminishes substrate binding and alters solubility
J. Biol. Chem.
267
526-541
1992
Escherichia coli
Yang, X.J.; Ruvinov, S.B.; Miles, E.W.
Overexpression and purification of separate tryptophan synthase alpha and beta subunits from Salmonella typhimurium
Protein Expr. Purif.
3
347-354
1992
Salmonella enterica subsp. enterica serovar Typhimurium
Ki Lim, W.; Sarkar, S.K.; Hardman, J.K.
Enzymatic properties of mutant Escherichia coli tryptophan synthase alpha-subunits
J. Biol. Chem.
266
20205-20212
1991
Escherichia coli
Blond-Elguindi, S.; Goldberg, M.E.
Kinetic characterization of early immunoreactive intermediates during the refolding of guanidine-unfolded Escherichia coli tryptophan synthase beta2 subunits
Biochemistry
29
2409-2417
1990
Escherichia coli
Sakaguchi, K.
The similarity of tryptophan synthetases of Anabaena variabilis and Chlorella ellipsoida with that of bacteria
Biochim. Biophys. Acta
220
580-593
1970
Trichormus variabilis, Pseudochlorella pringsheimii
Zhao, J.; Last, R.L.
Immunological characterization and chloroplast localization of the tryptophan biosynthetic enzymes of the flowering plant Arabidopsis thaliana
J. Biol. Chem.
270
6081-6087
1995
Arabidopsis thaliana
Jeong, M.S.; Jeong, J.K.; Park, K.S.; Kim, H.T.; Lee, K.M.; Lim, W.K.; Jang, S.B.
Crystallization and preliminary X-ray analysis of tryptophan synthase alpha-subunits from Escherichia coli
Acta Crystallogr. Sect. D
60
132-134
2004
Escherichia coli
Kim, J.W.; Kim, E.Y.; Park, H.H.; Jung, J.E.; Kim, H.D.; Shin, H.J.; Lim, W.K.
Homodimers of mutant tryptophan synthase alpha-subunits in Escherichia coli
Biochem. Biophys. Res. Commun.
289
568-572
2001
Escherichia coli
Jeong, J.K.; Shin, H.J.; Kim, J.W.; Lee, C.H.; Kim, H.D.; Lim, W.K.
Fluorescence and folding properties of Tyr mutant tryptophan synthase alpha-subunits from Escherichia coli
Biochem. Biophys. Res. Commun.
300
29-35
2003
Escherichia coli
Nibeilliu, M.E.; Malthouse, J.P.
The stereospecificity and catalytic efficiency of the tryptophan synthase catalysed exchange of the alpha-protons of amino acids
Biochem. J.
381
847-852
2004
Salmonella enterica subsp. enterica serovar Typhimurium
Zitzewitz, J.A.; Matthews, C.R.
Molecular dissection of the folding mechanism of the alpha subunit of tryptophan synthase: an amino-terminal autonomous folding unit controls several rate-limiting steps in the folding of a single domain protein
Biochemistry
38
10205-10214
1999
Escherichia coli
Sachpatzidis, A.; Dealwis, C.; Lubetsky, J.B.; Liang, P.H.; Anderson, K.S.; Lolis, E.
Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase
Biochemistry
38
12665-12674
1999
Salmonella enterica subsp. enterica serovar Typhimurium
Gualfetti, P.J.; Iwakura, M.; Lee, J.C.; Kihara, H.; Bilsel, O.; Zitzewitz, J.A.; Matthews, C.R.
Apparent radii of the native, stable intermediates and unfolded conformers of the alpha-subunit of tryptophan synthase from E. coli, a TIM barrel protein
Biochemistry
38
13367-13378
1999
Escherichia coli
Weyand, M.; Schlichting, I.
Crystal structure of wild-type tryptophan synthase complexed with the natural substrate indole-3-glycerol phosphate
Biochemistry
38
16469-16480
1999
Salmonella enterica subsp. enterica serovar Typhimurium
Bahar, I.; Jernigan, R.L.
Cooperative fluctuations and subunit communication in tryptophan synthase
Biochemistry
38
3478-3490
1999
Salmonella enterica subsp. enterica serovar Typhimurium
Woehl, E.; Dunn, M.F.
Mechanisms of monovalent cation action in enzyme catalysis: the first stage of the tryptophan synthase beta-reaction
Biochemistry
38
7118-7130
1999
Salmonella enterica subsp. enterica serovar Typhimurium
Woehl, E.; Dunn, M.F.
Mechanisms of monovalent cation action in enzyme catalysis: the tryptophan synthase alpha-, beta-, and alphabeta-reactions
Biochemistry
38
7131-7141
1999
Salmonella enterica subsp. enterica serovar Typhimurium
Fan, Y.X.; McPhie, P.; Miles, E.W.
Guanidine hydrochloride exerts dual effects on the tryptophan synthase alpha2beta2 complex as a cation Activator and as a modulator of the active site conformation
Biochemistry
38
7881-7890
1999
Salmonella enterica subsp. enterica serovar Typhimurium
Fan, Y.X.; McPhie, P.; Miles, E.W.
Regulation of tryptophan synthase by temperature, monovalent cations, and an allosteric ligand. Evidence from Arrhenius plots, absorption spectra, and primary kinetic isotope effects
Biochemistry
39
4692-4703
2000
Salmonella enterica subsp. enterica serovar Typhimurium
Weber-Ban, E.; Hur, O.; Bagwell, C.; Banik, U.; Yang, L.H.; Miles, E.W.; Dunn, M.F.
Investigation of allosteric linkages in the regulation of tryptophan synthase: the roles of salt bridges and monovalent cations probed by site-directed mutation, optical spectroscopy, and kinetics
Biochemistry
40
3497-3511
2001
Salmonella enterica subsp. enterica serovar Typhimurium
Ferrari, D.; Yang, L.H.; Miles, E.W.; Dunn, M.F.
BetaD305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity
Biochemistry
40
7421-7432
2001
Salmonella enterica subsp. enterica serovar Typhimurium
Hur, O.; Niks, D.; Casino, P.; Dunn, M.F.
Proton transfers in the beta-reaction catalyzed by tryptophan synthase
Biochemistry
41
9991-10001
2002
Salmonella enterica subsp. enterica serovar Typhimurium
Ferrari, D.; Niks, D.; Yang, L.H.; Miles, E.W.; Dunn, M.F.
Allosteric communication in the tryptophan synthase bienzyme complex: roles of the beta-subunit aspartate 305-arginine 141 salt bridge
Biochemistry
42
7807-7818
2003
Salmonella enterica subsp. enterica serovar Typhimurium
Marabotti, A.; Cozzini, P.; Mozzarelli, A.
Novel allosteric effectors of the tryptophan synthase alpha(2)beta(2) complex identified by computer-assisted molecular modeling
Biochim. Biophys. Acta
1476
287-299
2000
Salmonella enterica subsp. enterica serovar Typhimurium
Raboni, S.; Pioselli, B.; Bettati, S.; Mozzarelli, A.
The molecular pathway for the allosteric regulation of tryptophan synthase
Biochim. Biophys. Acta
1647
157-160
2003
Salmonella enterica subsp. enterica serovar Typhimurium
Rondard, P.; Bedouelle, H.
Mutational scanning of a hairpin loop in the tryptophan synthase beta-subunit implicated in allostery and substrate channeling
Biol. Chem.
381
1185-1193
2000
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Miles, E.W.
Tryptophan synthase: a multienzyme complex with an intramolecular tunnel
Chem. Rec.
1
140-151
2001
Salmonella enterica subsp. enterica serovar Typhimurium
Tang, X.F.; Ezaki, S.; Atomi, H.; Imanaka, T.
Biochemical analysis of a thermostable tryptophan synthase from a hyperthermophilic archaeon
Eur. J. Biochem.
267
6369-6377
2000
Thermococcus kodakarensis
Ro, H.S.; Wilson Miles, E.
Catalytic mechanism of the tryptophan synthase alpha(2)beta(2) complex. Effects of pH, isotopic substitution, and allosteric ligands
J. Biol. Chem.
274
31189-31194
1999
Salmonella enterica subsp. enterica serovar Typhimurium
Ro, H.S.; Miles, E.W.
Structure and function of the tryptophan synthase alpha(2)beta(2) complex. Roles of beta subunit histidine 86
J. Biol. Chem.
274
36439-36445
1999
Salmonella enterica subsp. enterica serovar Typhimurium
Fan, Y.X.; McPhie, P.; Miles, E.W.
Thermal repair of tryptophan synthase mutations in a regulatory intersubunit salt bridge. Evidence from Arrhenius plots, absorption spectra, and primary kinetic isotope effects
J. Biol. Chem.
275
20302-20307
2000
Salmonella enterica subsp. enterica serovar Typhimurium
Weyand, M.; Schlichting, I.
Structural basis for the impaired channeling and allosteric inter-subunit communication in the beta A169L/beta C170W mutant of tryptophan synthase
J. Biol. Chem.
275
41058-41063
2000
Salmonella enterica subsp. enterica serovar Typhimurium
Mozzarelli, A.; Peracchi, A.; Rovegno, B.; Dale, G.; Rossi, G.L.; Dunn, M.F.
Effect of pH and monovalent cations on the formation of quinonoid intermediates of the tryptophan synthase alpha2beta2 complex in solution and in the crystal
J. Biol. Chem.
275
6956-6962
2000
Salmonella enterica subsp. enterica serovar Typhimurium
Yamagata, Y.; Ogasahara, K.; Hioki, Y.; Lee, S.J.; Nakagawa, A.; Nakamura, H.; Ishida, M.; Kuramitsu, S.; Yutani, K.
Entropic stabilization of the tryptophan synthase alpha-subunit from a hyperthermophile, Pyrococcus furiosus. X-ray analysis and calorimetry
J. Biol. Chem.
276
11062-11071
2001
Pyrococcus furiosus (Q8U094), Pyrococcus furiosus
Marabotti, A.; De Biase, D.; Tramonti, A.; Bettati, S.; Mozzarelli, A.
Allosteric communication of tryptophan synthase. Functional and regulatory properties of the beta S178P mutant
J. Biol. Chem.
276
17747-17753
2001
Salmonella enterica subsp. enterica serovar Typhimurium
Weyand, M.; Schlichting, I.; Marabotti, A.; Mozzarelli, A.
Crystal structures of a new class of allosteric effectors complexed to tryptophan synthase
J. Biol. Chem.
277
10647-10652
2002
Salmonella enterica subsp. enterica serovar Typhimurium
Hettwer, S.; Sterner, R.
A novel tryptophan synthase beta-subunit from the hyperthermophile Thermotoga maritima. Quaternary structure, steady-state kinetics, and putative physiological role
J. Biol. Chem.
277
8194-8201
2002
Thermotoga maritima
Osborne, A.; Teng, Q.; Miles, E.W.; Phillips, R.S.
Detection of Open and Closed Conformations of Tryptophan Synthase by 15N-Heteronuclear Single-Quantum Coherence Nuclear Magnetic Resonance of Bound 1-15N-L-Tryptophan
J. Biol. Chem.
278
44083-44090
2003
Escherichia coli
Ogasahara, K.; Ishida, M.; Yutani, K.
Stimulated interaction between and subunits of tryptophan synthase from hyperthermophile enhances its thermal stability
J. Biol. Chem.
278
8922-8928
2003
Pyrococcus furiosus
Schiaretti, F.; Bettati, S.; Viappiani, C.; Mozzarelli, A.
pH dependence of tryptophan synthase catalytic mechanism. I. The first stage, the beta-elimination reaction
J. Biol. Chem.
279
29572-29582
2004
Salmonella enterica subsp. enterica serovar Typhimurium
Kulik, V.; Weyand, M.; Seidel, R.; Niks, D.; Arac, D.; Dunn, M.F.; Schlichting, I.
On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase
J. Mol. Biol.
324
677-690
2002
Salmonella enterica subsp. enterica serovar Typhimurium
Vadrevu, R.; Falzone, C.J.; Matthews, C.R.
Partial NMR assignments and secondary structure mapping of the isolated alpha subunit of Escherichia coli tryptophan synthase, a 29-kD TIM barrel protein
Protein Sci.
12
185-191
2003
Escherichia coli
Bang, W.; Lang, S.; Sahm, H.; Wagner, F.
Production of L-tryptophan by Escherichia coli cells
Biotechnol. Bioeng.
25
999-1011
1983
Escherichia coli
Jeong, M.S.; Jeong, J.K.; Lim, W.K.; Jang, S.B.
Structures of wild-type and P28L/Y173F tryptophan synthase alpha-subunits from Escherichia coli
Biochem. Biophys. Res. Commun.
323
1257-1264
2004
Escherichia coli (P0A877), Escherichia coli
Lee, S.J.; Ogasahara, K.; Ma, J.; Nishio, K.; Ishida, M.; Yamagata, Y.; Tsukihara, T.; Yutani, K.
Conformational changes in the tryptophan synthase from a hyperthermophile upon alpha2beta2 complex formation: crystal structure of the complex
Biochemistry
44
11417-11427
2005
Pyrococcus furiosus
Nishio, K.; Morimoto, Y.; Ishizuka, M.; Ogasahara, K.; Tsukihara, T.; Yutani, K.
Conformational changes in the alpha-subunit coupled to binding of the beta 2-subunit of tryptophan synthase from Escherichia coli: crystal structure of the tryptophan synthase alpha-subunit alone
Biochemistry
44
1184-1192
2005
Escherichia coli (P0A877), Escherichia coli
Phillips, R.S.; Miles, E.W.; Holtermann, G.; Goody, R.S.
Hydrostatic pressure affects the conformational equilibrium of Salmonella typhimurium tryptophan synthase
Biochemistry
44
7921-7928
2005
Salmonella enterica subsp. enterica serovar Typhimurium
Hioki, Y.; Ogasahara, K.; Lee, S.J.; Ma, J.; Ishida, M.; Yamagata, Y.; Matsuura, Y.; Ota, M.; Ikeguchi, M.; Kuramitsu, S.; Yutani, K.
The crystal structure of the tryptophan synthase beta subunit from the hyperthermophile Pyrococcus furiosus. Investigation of stabilization factors
Eur. J. Biochem.
271
2624-2635
2004
Pyrococcus furiosus (Q8U093), Pyrococcus furiosus
Pioselli, B.; Bettati, S.; Mozzarelli, A.
Confinement and crowding effects on tryptophan synthase alpha2beta2 complex
FEBS Lett.
579
2197-2202
2005
Salmonella enterica subsp. enterica serovar Typhimurium
Asada, Y.; Sawano, M.; Ogasahara, K.; Nakamura, J.; Ota, M.; Kuroishi, C.; Sugahara, M.; Yutani, K.; Kunishima, N.
Stabilization mechanism of the tryptophan synthase alpha-subunit from Thermus thermophilus HB8: X-ray crystallographic analysis and calorimetry
J. Biochem.
138
343-353
2005
Thermus thermophilus (Q5SJC0), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SJC0)
Wintrode, P.L.; Rojsajjakul, T.; Vadrevu, R.; Matthews, C.R.; Smith, D.L.
An obligatory intermediate controls the folding of the alpha-subunit of tryptophan synthase, a TIM barrel protein
J. Mol. Biol.
347
911-919
2005
Escherichia coli
Wu, Y.; Vadrevu, R.; Yang, X.; Matthews, C.R.
Specific structure appears at the N terminus in the sub-millisecond folding intermediate of the alpha subunit of tryptophan synthase, a TIM barrel protein
J. Mol. Biol.
351
445-452
2005
Escherichia coli
Kulik, V.; Hartmann, E.; Weyand, M.; Frey, M.; Gierl, A.; Niks, D.; Dunn, M.F.; Schlichting, I.
On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes
J. Mol. Biol.
352
608-620
2005
Salmonella enterica subsp. enterica serovar Typhimurium
Jeong, M.S.; Jang, S.B.
Crystallization and X-ray crystallographic studies of wild-type and mutant tryptophan synthase alpha-subunits from Escherichia coli
Mol. Cells
19
219-222
2005
Escherichia coli
Phillips, R.S.; McPhie, P.; Miles, E.W.; Marchal, S.; Lange, R.
Quantitative effects of allosteric ligands and mutations on conformational equilibria in Salmonella typhimurium tryptophan synthase
Arch. Biochem. Biophys.
470
8-19
2008
Salmonella enterica subsp. enterica serovar Typhimurium
Leopoldseder, S.; Hettwer, S.; Sterner, R.
Evolution of multi-enzyme complexes: the case of tryptophan synthase
Biochemistry
45
14111-14119
2006
Saccharolobus solfataricus
Raboni, S.; Mozzarelli, A.; Cook, P.F.
Control of ionizable residues in the catalytic mechanism of tryptophan synthase from Salmonella typhimurium
Biochemistry
46
13223-13234
2007
Salmonella enterica subsp. enterica serovar Typhimurium
Ngo, H.; Harris, R.; Kimmich, N.; Casino, P.; Niks, D.; Blumenstein, L.; Barends, T.R.; Kulik, V.; Weyand, M.; Schlichting, I.; Dunn, M.F.
Synthesis and characterization of allosteric probes of substrate channeling in the tryptophan synthase bienzyme complex
Biochemistry
46
7713-7727
2007
Salmonella enterica subsp. enterica serovar Typhimurium
Ngo, H.; Kimmich, N.; Harris, R.; Niks, D.; Blumenstein, L.; Kulik, V.; Barends, T.R.; Schlichting, I.; Dunn, M.F.
Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the beta-reaction by alpha-site ligands
Biochemistry
46
7740-7753
2007
Salmonella enterica subsp. enterica serovar Typhimurium
Spyrakis, F.; Raboni, S.; Cozzini, P.; Bettati, S.; Mozzarelli, A.
Allosteric communication between alpha and beta subunits of tryptophan synthase: Modelling the open-closed transition of the alpha subunit
Biochim. Biophys. Acta
1764
1102-1109
2006
Salmonella enterica subsp. enterica serovar Typhimurium
Dias, M.V.; Canduri, F.; da Silveira, N.J.; Czekster, C.M.; Basso, L.A.; Palma, M.S.; Santos, D.S.; de Azevedo, W.F.
Molecular models of tryptophan synthase from Mycobacterium tuberculosis complexed with inhibitors
Cell Biochem. Biophys.
44
375-384
2006
Mycobacterium tuberculosis
Goss, R.J.; Newill, P.L.
A convenient enzymatic synthesis of L-halotryptophans
Chem. Commun. (Camb. )
47
4924-4925
2006
Salmonella enterica
-
Akers, J.C.; Tan, M.
Molecular mechanism of tryptophan-dependent transcriptional regulation in Chlamydia trachomatis
J. Bacteriol.
188
4236-4243
2006
Chlamydia trachomatis
Wu, Y.; Vadrevu, R.; Kathuria, S.; Yang, X.; Matthews, C.R.
A tightly packed hydrophobic cluster directs the formation of an off-pathway sub-millisecond folding intermediate in the alpha subunit of tryptophan synthase, a TIM barrel protein
J. Mol. Biol.
366
1624-1638
2007
Escherichia coli (P0A877)
Carlson, J.H.; Wood, H.; Roshick, C.; Caldwell, H.D.; McClarty, G.
In vivo and in vitro studies of Chlamydia trachomatis TrpR:DNA interactions
Mol. Microbiol.
59
1678-1691
2006
Chlamydia trachomatis
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Escherichia coli (P0A877), Escherichia coli
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