4.1.1.1: pyruvate decarboxylase
This is an abbreviated version!
For detailed information about pyruvate decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.1
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4.1.1.1
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dendritic
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plasmacytoid
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toll-like
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thiamin
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claim
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autoimmune
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prescript
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ifn-alpha
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pharmacy
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lymphoid
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herbicide
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zymomonas
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branched-chain
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cdc
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acetaldehyde
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mobilis
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sulfonylurea
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real-world
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tregs
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adhes
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interferon-alpha
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insurance
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lupus
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antigen-presenting
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statin
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costimulatory
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lipoylated
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erythematosus
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nonadherence
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refill
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medicare
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tolerogenic
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dabigatran
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acetolactate
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marketscan
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dispensing
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synthesis
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hla-dr
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antimitochondrial
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acetoin
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dihydrolipoyl
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biotechnology
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pharmacist
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herbicide-resistant
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beneficiaries
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icd-9-cm
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dihydrolipoamide
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transacetylase
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rivaroxaban
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dichloroacetate
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enrollees
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lipoate
- 4.1.1.1
- dendritic
-
plasmacytoid
-
toll-like
- thiamin
-
claim
- autoimmune
-
prescript
- ifn-alpha
-
pharmacy
-
lymphoid
-
herbicide
- zymomonas
-
branched-chain
- cdc
- acetaldehyde
- mobilis
- sulfonylurea
-
real-world
-
tregs
-
adhes
- interferon-alpha
-
insurance
-
lupus
-
antigen-presenting
- statin
-
costimulatory
-
lipoylated
- erythematosus
-
nonadherence
-
refill
-
medicare
-
tolerogenic
- dabigatran
- acetolactate
-
marketscan
-
dispensing
- synthesis
-
hla-dr
-
antimitochondrial
- acetoin
-
dihydrolipoyl
- biotechnology
-
pharmacist
-
herbicide-resistant
-
beneficiaries
-
icd-9-cm
- dihydrolipoamide
- transacetylase
- rivaroxaban
- dichloroacetate
-
enrollees
- lipoate
Reaction
Synonyms
2-oxo acid carboxylyase, 8-10 nm cytoplasmic filament-associated protein, acetohydroxyacid synthase, AHAS, alpha-Carboxylase, alpha-Keto acid carboxylase, ANC27, bifunctional pyruvate decarboxylase/pyruvate ferredoxin oxidoreductase, Decarboxylase, pyruvate, GPDC1, IFPL730, KivD, KlPDC, KviD, NcPDC, P59NC, PDC, PDC I, PDC II, PDC1, Pdc1p, PDC2, PDC3, PDC4, Pdc5, Pdc5p, Pdc6, PDCS.c., PDCZ.m., PDHC, POR, pyruvamide-activated yeast pyruvate decarboxylase, pyruvate decarboxylase, pyruvate decarboxylase 1, pyruvate decarboxylase 2, pyruvate decarboxylase complex, Pyruvic decarboxylase, R-selective pyruvate decarboxylase, SCPDC, scpdc1, ScPDC5, TTHA1213, yeast pyruvate decarboxylase, YPDC, ZbPDC, ZmPDC
ECTree
4.1.1.1 pyruvate decarboxylaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 4.1.1.1 - pyruvate decarboxylase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
([2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethoxy]hydroxyphosphoryldifluoromethyl)phosphonic acid
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([2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethoxy]hydroxyphosphorylmethyl) phosphonic acid
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2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethanol
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2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl diphosphate
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2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-5-methyl-1H-[1,2,3]triazol-4-yl]ethyl diphosphate
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2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethyl trihydrogen diphosphate
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a thiamine diphosphate analogue, almost irreversible inhibition
2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl]ethyl trihydrogen diphosphate
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a methyl triazole analogue of thiamine diphosphate, almost irreversible inhibition
3-deazathiamine diphosphate
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12-step synthesis of the isoelectronic thiophene analogue of thiamine diphosphate, overview
mono(2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl) iminodiacetate
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mono[2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl] malonate
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N-([2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethoxy]sulfonyl)phosphoramidic acid
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O-2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl sulfamate
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Omeprazole
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50% inhibition at 0.016 mg/ml for enzyme from metronidazole-resistant strain or from cells grown under iron-limited conditions, little effect on enzyme from metronidazole-susceptible strain
thiamine diphosphate
PDC I, complete inhibition at 75 mM, PDC II, complete inhibition at 100 mM
[(2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethoxy)sulfonyl]phosphoramidic acid
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a phosphoramidic acid thiamine diphosphate analogue
[[(2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethoxy)(hydroxy)phosphoryl](difluoro)methyl]phosphonic acid
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a difluoromethylenediphosphonate ester thiamine diphosphate analogue
[[(2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1H-1,2,3-triazol-4-yl]ethoxy)(hydroxy)phosphoryl]methyl]phosphonic acid
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a methylenediphosphonate ester thiamine diphosphate analogue
(E)-4-(4-Chlorophenyl)-2-oxo-3-butenoic acid
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wild type enzyme and mutant enzymes D28A, H114F, H115F and E477Q
acetaldehyde
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inhibits, more resistant than PDC from Zymomonas mobilis, 8 mM, 2h, stable
benzaldehyde
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after a 20 h incubation with 30 mM benzaldehyde, the residual activity is 84% of the initial activity, enzyme stability dramatically decreases in the presence of 200 mM benzaldehyde (27% residual activity after 3 h incubation)
pyruvate
substrate inhibition at pyruvate concentrations above 20 mM for isoenzyme 1; substrate inhibition at pyruvate concentrations above 40 mM for isoenzyme 2
additional information
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growth on a medium with oxythiamine increases enzyme activity, but may be in response to an earlier inhibition of enzyme leading to an accumulation of pyruvate, which induces the biosynthesis of enzyme apoform
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additional information
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dephosphorylation of Pdc1p by alkaline phosphatase inhibits the enzyme activity by 50%
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additional information
not inhibited by 25 mM EGTA or EDTA, at 37°C, pH 6.5, 90 min, without cofactors
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additional information
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not inhibited by 25 mM EGTA or EDTA, at 37°C, pH 6.5, 90 min, without cofactors
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additional information
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no product inhibition by (R)-1-phenyl-1-hydroxy-propane-2-one
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