Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.1.1.1: pyruvate decarboxylase

This is an abbreviated version!
For detailed information about pyruvate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.1

Reaction

a 2-oxo carboxylate
=
an aldehyde
 +
CO2

Synonyms

2-oxo acid carboxylyase, 8-10 nm cytoplasmic filament-associated protein, acetohydroxyacid synthase, AHAS, alpha-Carboxylase, alpha-Keto acid carboxylase, ANC27, bifunctional pyruvate decarboxylase/pyruvate ferredoxin oxidoreductase, Decarboxylase, pyruvate, GPDC1, IFPL730, KivD, KlPDC, KviD, NcPDC, P59NC, PDC, PDC I, PDC II, PDC1, Pdc1p, PDC2, PDC3, PDC4, Pdc5, Pdc5p, Pdc6, PDCS.c., PDCZ.m., PDHC, POR, pyruvamide-activated yeast pyruvate decarboxylase, pyruvate decarboxylase, pyruvate decarboxylase 1, pyruvate decarboxylase 2, pyruvate decarboxylase complex, Pyruvic decarboxylase, R-selective pyruvate decarboxylase, SCPDC, scpdc1, ScPDC5, TTHA1213, yeast pyruvate decarboxylase, YPDC, ZbPDC, ZmPDC

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.1 pyruvate decarboxylase

Renatured

Renatured on EC 4.1.1.1 - pyruvate decarboxylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
renaturation of apoenzyme with MgCl2 is achieved by incubation of dialyzed enzyme with 1 mM thiamine diphosphate and increasing concentrations of MgCl2
-
study of subunit dissociation into two types of dimers depending on the experimental conditions and their reassociation
-
unfolding and folding kinetics after treatment with urea, reactivation study in terms of dependence on different conditions and additives, reactivation of homomeric PDC requires both refolding to monomers and their correct association to enzymatically active dimers or tetramers
-