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4.1.1.1: pyruvate decarboxylase

This is an abbreviated version!
For detailed information about pyruvate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.1

Reaction

a 2-oxo carboxylate
=
an aldehyde
 +
CO2

Synonyms

2-oxo acid carboxylyase, 8-10 nm cytoplasmic filament-associated protein, acetohydroxyacid synthase, AHAS, alpha-Carboxylase, alpha-Keto acid carboxylase, ANC27, bifunctional pyruvate decarboxylase/pyruvate ferredoxin oxidoreductase, Decarboxylase, pyruvate, GPDC1, IFPL730, KivD, KlPDC, KviD, NcPDC, P59NC, PDC, PDC I, PDC II, PDC1, Pdc1p, PDC2, PDC3, PDC4, Pdc5, Pdc5p, Pdc6, PDCS.c., PDCZ.m., PDHC, POR, pyruvamide-activated yeast pyruvate decarboxylase, pyruvate decarboxylase, pyruvate decarboxylase 1, pyruvate decarboxylase 2, pyruvate decarboxylase complex, Pyruvic decarboxylase, R-selective pyruvate decarboxylase, SCPDC, scpdc1, ScPDC5, TTHA1213, yeast pyruvate decarboxylase, YPDC, ZbPDC, ZmPDC

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.1 pyruvate decarboxylase

pH Range

pH Range on EC 4.1.1.1 - pyruvate decarboxylase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.6 - 8
-
pH 4.6: about 35% of maximal activity, pH 8.0: about 70% of maximal activity
5
-
about 50% of maximal activity at pH 5.0 and at pH 7.5
5 - 7
-
pH-dependence overview
5.5 - 7
-
pH 5.5: about 60% of maximal activity, pH 7.0: about 45% of maximal activity
5.5 - 7.2
-
nearly identical Vmax values in the pH range, wild-type YPDC
5.9 - 8
16% of maximal activity at pH 8.0
7
-
wild-type YPDC forms more acetaldehyde at higher pH, followed by a decrease above pH 7
8 - 11.5
-
pH 8.0: about 60% of maximal activity, pH 10.0: about 50% of maximal activity
additional information