Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.1 extracted from

  • Wang, Q.; He, P.; Lu, D.; Shen, A.; Jiang, N.
    Purification, characterization, cloning and expression of pyruvate decarboxylase from Torulopsis glabrata IFO005 (2004), J. Biochem., 136, 447-455.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
pyruvate
-
[Candida] glabrata

Inhibitors

Inhibitors Comment Organism Structure
Ag+ complete inhibition at 20 mM [Candida] glabrata
Cu+ complete inhibition at 20 mM [Candida] glabrata
glyoxylate complete inhibition [Candida] glabrata
thiamine diphosphate PDC I, complete inhibition at 75 mM, PDC II, complete inhibition at 100 mM [Candida] glabrata

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.8
-
pyruvate isoform PDC I, pH 6.0, 30°C [Candida] glabrata
0.9
-
pyruvate isoform PDC II, pH 6.0, 30°C [Candida] glabrata

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required [Candida] glabrata

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58700
-
2 * 58700, SDS-PAGE, 2 * 62000, calculated, both isoform PDC I and PDC II [Candida] glabrata
62000
-
2 * 58700, SDS-PAGE, 2 * 62000, calculated, both isoform PDC I and PDC II [Candida] glabrata
120000
-
PAGE [Candida] glabrata
150000
-
gel filtration [Candida] glabrata

Organism

Organism UniProt Comment Textmining
[Candida] glabrata Q6FJA3 strain IFO005, isoforms PDC I and PDC II
-
[Candida] glabrata CBS 138 Q6FJA3 strain IFO005, isoforms PDC I and PDC II
-

Purification (Commentary)

Purification (Comment) Organism
-
[Candida] glabrata

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
21.7
-
isoform PDC I, pH 6.0, 30°C [Candida] glabrata
40
-
isoform PDC II, pH 6.0, 30°C [Candida] glabrata

Storage Stability

Storage Stability Organism
-20°C, lyophilized preparation, stable for at least 3 months [Candida] glabrata

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate
-
[Candida] glabrata acetaldehyde + CO2
-
?
pyruvate
-
[Candida] glabrata CBS 138 acetaldehyde + CO2
-
?

Subunits

Subunits Comment Organism
dimer 2 * 58700, SDS-PAGE, 2 * 62000, calculated, both isoform PDC I and PDC II [Candida] glabrata

Synonyms

Synonyms Comment Organism
PDC I
-
[Candida] glabrata
PDC II
-
[Candida] glabrata

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
40
-
1 h, 73.2% residual activity, isoform PDC, 93.2% residual activity, isoform PDC II [Candida] glabrata
50
-
1 h, 23.9% residual activity, isoform PDC, 43.1% residual activity, isoform PDC II [Candida] glabrata
60
-
1 h, 3% residual activity, isoform PDC, 2.7% residual activity, isoform PDC II [Candida] glabrata

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
43.6
-
pyruvate isoform PDC I, pH 6.0, 30°C [Candida] glabrata
77
-
pyruvate isoform PDC II, pH 6.0, 30°C [Candida] glabrata

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.5
-
[Candida] glabrata

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.5 7.5
-
[Candida] glabrata

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
[Candida] glabrata