3.5.4.4: adenosine deaminase
This is an abbreviated version!
For detailed information about adenosine deaminase, go to the full flat file.
Word Map on EC 3.5.4.4
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3.5.4.4
-
purine
-
nucleoside
-
lymphocyte
-
immunodeficiency
-
inosine
-
pleural
-
tuberculous
-
deamination
-
effusion
-
erythrocyte
-
phosphorylase
-
agonist
-
leukemia
-
5'-nucleotidase
-
deoxyadenosine
-
marrow
-
xanthine
-
adenylate
-
hypoxanthine
-
t-cells
-
lymphoid
-
ehna
-
dipyridamole
-
purinergic
-
hematopoietic
-
exudative
-
lipolysis
-
pleurisy
-
meningitis
-
theophylline
-
datp
-
ecto-5\'-nucleotidase
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s-adenosylhomocysteine
-
2-chloroadenosine
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dpcpx
-
autoinflammatory
-
pericarditis
-
acid-fast
-
deoxycytidine
-
transudate
-
antilipolytic
-
diphosphohydrolase
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hypoxanthine-guanine
-
adenosine-induced
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ectonucleotidases
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n6-cyclopentyladenosine
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empyema
-
deaminases
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ntpdases
-
purinoceptors
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medicine
-
pharmacology
-
drug development
-
diagnostics
-
analysis
- 3.5.4.4
- purine
- nucleoside
- lymphocyte
- immunodeficiency
- inosine
- pleural
-
tuberculous
-
deamination
- effusion
- erythrocyte
- phosphorylase
- agonist
- leukemia
- 5'-nucleotidase
- deoxyadenosine
- marrow
- xanthine
- adenylate
- hypoxanthine
- t-cells
-
lymphoid
- ehna
- dipyridamole
-
purinergic
-
hematopoietic
-
exudative
-
lipolysis
- pleurisy
- meningitis
- theophylline
- datp
-
ecto-5\'-nucleotidase
- s-adenosylhomocysteine
- 2-chloroadenosine
- dpcpx
-
autoinflammatory
- pericarditis
-
acid-fast
- deoxycytidine
-
transudate
-
antilipolytic
-
diphosphohydrolase
-
hypoxanthine-guanine
-
adenosine-induced
- ectonucleotidases
-
n6-cyclopentyladenosine
- empyema
- deaminases
- ntpdases
-
purinoceptors
- medicine
- pharmacology
- drug development
- diagnostics
- analysis
Reaction
Synonyms
AD, ADA, ADA1, ADA2, ADAI, ADAII, ADAIII, Adenosine aminohydrolase, adenosine deaminase, adenosine deaminase 1, adenosine deaminase 2, ciADA, HadA, LADA, MadA, MJ1541, PvADA, SADA, SCO4901, TadA
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 3.5.4.4 - adenosine deaminase
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REACTION DIAGRAM
viramidine + H2O
ribavirin + NH3
-
the enzyme catalyzes viramidine deamination to ribavirin in vivo as a prodrug conversion to active drug, pharmacokinetic analysis, overview
-
-
?
2'-deoxyadenosine + H2O
2'-deoxyinosine + NH3
-
the enzyme plays an important role in the immune system
-
-
?
5'-methylthioadenosine + H2O
5'-methylthioinosine + NH3
adenosine deaminase has a secondary function in recycling methylthiopurines from the polyamine biosynthetic pathway
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-
ir
inosine + NH3
-
key enzyme in controlling intra- and extracellular adenosine levels
-
-
?
adenosine + H2O
inosine + NH3
key enzyme involved in the purine metabolism
-
-
?
adenosine + H2O
inosine + NH3
-
-
-
-
?
adenosine + H2O
inosine + NH3
isozyme ADA2 is important in lymphocyte activation, and may be active in sites of inflammation and during hypoxia and in areas of tumor growth with elevated adenosine levels and acidic pH, overview
-
-
?
adenosine + H2O
inosine + NH3
-
the enzyme activity is correlated with the content in malonaldehyde in nasal polyps and nasal mucosa, overview
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-
?
adenosine + H2O
inosine + NH3
-
the enzyme expression and activity is suppressed in normal pregnancy, but not in woman with recurrent spontaneous abortion
-
-
?
adenosine + H2O
inosine + NH3
-
the enzyme is involved in differentiation and maturation of the lymphoid system, the enzyme activity is decreased in multiple sclerosis patients irrespective of whether patients have relapsing-remitting or chronic progressive multiple sclerosis, overview
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-
?
adenosine + H2O
inosine + NH3
-
the enzyme plays an important role in the immune system
-
-
?
adenosine + H2O
inosine + NH3
-
metabolization of extracellular adenosine leads to exacerbation of inflammation
-
-
ir
adenosine + H2O
inosine + NH3
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adenosine deaminase is involved in purine metabolism and is a key enzyme for the control of the cellular levels of adenosine
-
-
?
adenosine + H2O
inosine + NH3
the enzyme is crucial for purine metabolism and normal immune competence
-
-
ir
adenosine + H2O
inosine + NH3
-
the enzyme is important in thymocyte development, especially in late stages, overview
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-
?
adenosine + H2O
inosine + NH3
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the enzyme is important in thymocyte development, especially in late stages, overview
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-
?
adenosine + H2O
inosine + NH3
-
the enzyme is involved in the bile duct-inflammation and fibrosis caused chronic fascioliasis including an atrophy of the liver parenchyma and liver cirrhosis
-
-
ir
adenosine + H2O
inosine + NH3
-
adenosine deamination is involved in the essential pathway of purine salvage in Plasmodium falciparum, and inhibition of purine salvage results in parasite death
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-
?
?
-
-
regulatory role of dipeptidyl peptidase IV on adenosine deaminase activity
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-
?
additional information
?
-
-
the enzyme is bound and complexed by the cell membraneous dipeptidyl peptidase IV, which is identical to the activated immune cell antigen CD26, playing a role in the immune system, overview
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-
?
additional information
?
-
-
adenosine deaminase inhibition enhances the efficiency of signal transduction and inotropic response mediated by A1 adenosine receptor in hyperthyroid guinea pig atrium via elevated intracellular adenosine levels, overview
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-
?
additional information
?
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-
the enzyme is involved in purine metabolism and plays an important role in the mechanism of the immune system
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-
?
additional information
?
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-
the large isozyme is bound and complexed by the cell membraneous dipeptidyl peptidase IV, which is identical to the activated immune cell antigen CD26, playing a role in the immune system, overview
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-
?
additional information
?
-
-
adenosine modulates the immune system and inhibits inflammation via reduction of cytokine biosynthesis and neutrophil functions, enzyme inhibition reduces inflammation in experimental colitis, overview
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-
?