3.5.4.4: adenosine deaminase
This is an abbreviated version!
For detailed information about adenosine deaminase, go to the full flat file.
Word Map on EC 3.5.4.4
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3.5.4.4
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purine
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nucleoside
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lymphocyte
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immunodeficiency
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inosine
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pleural
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tuberculous
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deamination
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effusion
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erythrocyte
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phosphorylase
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agonist
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leukemia
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5'-nucleotidase
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deoxyadenosine
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marrow
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xanthine
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adenylate
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hypoxanthine
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t-cells
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lymphoid
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ehna
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dipyridamole
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purinergic
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hematopoietic
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exudative
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lipolysis
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pleurisy
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meningitis
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theophylline
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datp
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ecto-5\'-nucleotidase
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s-adenosylhomocysteine
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2-chloroadenosine
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dpcpx
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autoinflammatory
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pericarditis
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acid-fast
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deoxycytidine
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transudate
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antilipolytic
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diphosphohydrolase
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hypoxanthine-guanine
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adenosine-induced
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ectonucleotidases
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n6-cyclopentyladenosine
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empyema
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deaminases
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ntpdases
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purinoceptors
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medicine
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pharmacology
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drug development
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diagnostics
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analysis
- 3.5.4.4
- purine
- nucleoside
- lymphocyte
- immunodeficiency
- inosine
- pleural
-
tuberculous
-
deamination
- effusion
- erythrocyte
- phosphorylase
- agonist
- leukemia
- 5'-nucleotidase
- deoxyadenosine
- marrow
- xanthine
- adenylate
- hypoxanthine
- t-cells
-
lymphoid
- ehna
- dipyridamole
-
purinergic
-
hematopoietic
-
exudative
-
lipolysis
- pleurisy
- meningitis
- theophylline
- datp
-
ecto-5\'-nucleotidase
- s-adenosylhomocysteine
- 2-chloroadenosine
- dpcpx
-
autoinflammatory
- pericarditis
-
acid-fast
- deoxycytidine
-
transudate
-
antilipolytic
-
diphosphohydrolase
-
hypoxanthine-guanine
-
adenosine-induced
- ectonucleotidases
-
n6-cyclopentyladenosine
- empyema
- deaminases
- ntpdases
-
purinoceptors
- medicine
- pharmacology
- drug development
- diagnostics
- analysis
Reaction
Synonyms
AD, ADA, ADA1, ADA2, ADAI, ADAII, ADAIII, Adenosine aminohydrolase, adenosine deaminase, adenosine deaminase 1, adenosine deaminase 2, ciADA, HadA, LADA, MadA, MJ1541, PvADA, SADA, SCO4901, TadA
ECTree
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General Information
General Information on EC 3.5.4.4 - adenosine deaminase
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malfunction
metabolism
physiological function
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apoptosis is enhanced in ADAR1-deficient cells following infection with wild type and V knockout measles virus but not following infection with C knockout measles virus or treatment with tumor necrosis factor-alpha or staurosporine
malfunction
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disruption of TADA has profound effects on chloroplast translation efficiency, leading to reduced yields of chloroplast-encoded proteins and impaired photosynthetic function
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ADA is a key enzyme in the pathway of hypoxanthine formation
metabolism
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ADA is a key enzyme in the pathway of hypoxanthine formation
metabolism
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ADA is a key enzyme in the pathway of hypoxanthine formation
metabolism
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ADA is a key enzyme in the pathway of hypoxanthine formation
metabolism
the enzyme is involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens
metabolism
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comparison of growth characteristics including intracellular protein levels, RNA content, and nucleotide pool sizes between the extreme halophile Halobacterium halobium and the moderate halophile Haloferax volcanii. The differences in the metabolism of purine bases and nucleosides and the sensitivity to purine analogs between the two halobacteria are reflected in differences in purine enzyme levels
metabolism
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comparison of growth characteristics including intracellular protein levels, RNA content, and nucleotide pool sizes between the extreme halophile Halobacterium halobium and the moderate halophile Haloferax volcanii. The differences in the metabolism of purine bases and nucleosides and the sensitivity to purine analogs between the two halobacteria are reflected in differences in purine enzyme levels
metabolism
important enzyme in the purine metabolism. Oxidative stress occurs in cattle experimentally infected by Fasciola hepatica, mainly due to excessive production of reactive oxygen species in the course of fasciolosis, contributing to hepatic damage. Increase in hepatic adenosine deaminase activity may contribute to the inflammatory process
metabolism
Plasmodium falciparum, a malarial pathogen, can only synthesize purine nucleotides employing a salvage pathway because it lacks de novo biosynthesis. Adenosine deaminase, one of the three purine salvage enzymes
metabolism
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the enzyme is involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens
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ADAR1 deaminase increases exogenous gene expression at the translational level by decreasing protein kinase regulated by RNA-dependent eIF-2alpha phosphorylation
physiological function
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ADAR1 is a proviral, antiapoptotic host factor in the context of measles virus infection. ADAR1 enhances the growth of measles virus. ADAR1 suppresses wild type and V knockout measles virus-induced apoptosis. ADAR1 does not protect against tumor necrosis factor-alpha- or staurosporine-induced apoptosis. ADAR1 suppresses wild type and V knockout measles virus-induced protein kinase regulated by RNA activation. ADAR1 suppresses interferon regulatory transcription factor-3 activation by wild type and V knockout measles viruses
physiological function
isozyme ADA1 does not induce T cell-dependent differentiation of monocytes into macrophages
physiological function
isozyme ADA2 but not ADA1 induces T cell-dependent differentiation of monocytes into macrophages and stimulates macrophage proliferation. ADA2 exhibits a growth factor activity and increases proliferation of CD4+ T cells. ADA2 binds to cells via proteoglycans and adenosine receptors
physiological function
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tRNA adenosine deaminase arginine is a chloroplast tRNA editing protein specifically required for deamination of chloroplast (cp)-tRNAArg(ACG) to cp-tRNAArg(ICG)
physiological function
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Trypanosoma evansi infection results in either the reduction or increase in the ADA activity in brain of rat. Alterations in ADA activity of the brain in Trypanosoma evansi-infected rats may have implications for pathogenesis of the disease
physiological function
adenosine deaminase is important in regulating the concentration of adenine nucleotides, molecules known to be involved on platelet aggregation
physiological function
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increased activity of adenosine deaminase as an effect of aflatoxins intoxication contributes directly to the inflammatory process and tissue damage, and might be involved in disease development