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3.5.4.4: adenosine deaminase

This is an abbreviated version!
For detailed information about adenosine deaminase, go to the full flat file.

Word Map on EC 3.5.4.4

Reaction

adenosine
+
H2O
=
Inosine
+
NH3

Synonyms

AD, ADA, ADA1, ADA2, ADAI, ADAII, ADAIII, Adenosine aminohydrolase, adenosine deaminase, adenosine deaminase 1, adenosine deaminase 2, ciADA, HadA, LADA, MadA, MJ1541, PvADA, SADA, SCO4901, TadA

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.4 adenosine deaminase

Expression

Expression on EC 3.5.4.4 - adenosine deaminase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
activity of ADA in striatum and in hippocampus do not change in acute hyperammonemia as compared to control levels
-
ADA activity is reduced in serum and erythrocytes in rats infected with Trypanosoma evansi compared to non-infected rats. ADA activity in lymphocytes is decreased after 4 days, when the parasitaemia is high and increases after 20 days, when the number of circulating parasites is low
-
adenosine deaminase levels increases in animals intoxicated by aflatoxin compared to the control group
-
enzyme activity is lowered in gastric tissues treated with the static magnetic field
-
HgCl2 does not alter ADA gene expression
-
interferon gamma inhibits secretion of ADA2 by macrophages
no change of activity is observed in the enzyme activity of colon tissues treated with the static magnetic field
-
subacute hepatitis leads to 135% increase in hepatic ADA activity, in hyperammonemic rats hepatic ADA activity is 3.2fold higher than in control animals. In the cerebellum of hyperammonemic rats ADA activity is increased by 26%. Activity of ADA in the neocortex from hyperammonemic rats is 46% higher than in control rats
-
the administration of 50 mg/kg methotrexate induces a significant decrease in the ADA activity in the cerebral cortex, kidney and liver, but not in the hippocampus
-