3.5.4.4: adenosine deaminase
This is an abbreviated version!
For detailed information about adenosine deaminase, go to the full flat file.
Word Map on EC 3.5.4.4
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3.5.4.4
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purine
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nucleoside
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lymphocyte
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immunodeficiency
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inosine
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pleural
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tuberculous
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deamination
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effusion
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erythrocyte
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phosphorylase
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agonist
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leukemia
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5'-nucleotidase
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deoxyadenosine
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marrow
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xanthine
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adenylate
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hypoxanthine
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t-cells
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lymphoid
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ehna
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dipyridamole
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purinergic
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hematopoietic
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exudative
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lipolysis
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pleurisy
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meningitis
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theophylline
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datp
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ecto-5\'-nucleotidase
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s-adenosylhomocysteine
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2-chloroadenosine
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dpcpx
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autoinflammatory
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pericarditis
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acid-fast
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deoxycytidine
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transudate
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antilipolytic
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diphosphohydrolase
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hypoxanthine-guanine
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adenosine-induced
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ectonucleotidases
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n6-cyclopentyladenosine
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empyema
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deaminases
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ntpdases
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purinoceptors
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medicine
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pharmacology
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drug development
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diagnostics
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analysis
- 3.5.4.4
- purine
- nucleoside
- lymphocyte
- immunodeficiency
- inosine
- pleural
-
tuberculous
-
deamination
- effusion
- erythrocyte
- phosphorylase
- agonist
- leukemia
- 5'-nucleotidase
- deoxyadenosine
- marrow
- xanthine
- adenylate
- hypoxanthine
- t-cells
-
lymphoid
- ehna
- dipyridamole
-
purinergic
-
hematopoietic
-
exudative
-
lipolysis
- pleurisy
- meningitis
- theophylline
- datp
-
ecto-5\'-nucleotidase
- s-adenosylhomocysteine
- 2-chloroadenosine
- dpcpx
-
autoinflammatory
- pericarditis
-
acid-fast
- deoxycytidine
-
transudate
-
antilipolytic
-
diphosphohydrolase
-
hypoxanthine-guanine
-
adenosine-induced
- ectonucleotidases
-
n6-cyclopentyladenosine
- empyema
- deaminases
- ntpdases
-
purinoceptors
- medicine
- pharmacology
- drug development
- diagnostics
- analysis
Reaction
Synonyms
AD, ADA, ADA1, ADA2, ADAI, ADAII, ADAIII, Adenosine aminohydrolase, adenosine deaminase, adenosine deaminase 1, adenosine deaminase 2, ciADA, HadA, LADA, MadA, MJ1541, PvADA, SADA, SCO4901, TadA
ECTree
3.5.4.4 adenosine deaminaseAdvanced search results
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Source Tissue on EC 3.5.4.4 - adenosine deaminase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
activity is determined in cattle experimentally infected by Fasciola hepatica on days 20, 40, 60 and 80 post-infection. A reduction in activity on day 20 post-infection, as well as an increase in adenosine deaminase activity on days 40 and 60 post-infection is observed when compared to the control. Based on these results, it can be conclude that ATP, ADP and AMP hydrolysis and adenosine deamination are altered in platelets of cattle infected by Fasciola hepatica
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reduced enzyme activity is associated with increased membrane fluidity in transformed versus normal fibroblasts
the salivary levels of adenosine deaminase activity are significantly elevated in animals with local inflammation, gastrointestinal disorder and respiratory disorder
additional information
from Friesian male cattle. Animals infected with Fasciola hepatica show lower enzyme activity on days 40 and 60 post infection compared with the uninfected control. The reduction on seric activity on days 40 and 60 post-inection can contribute to restrict the inflammatory response, and the subsequent cellular damage
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adenosine deaminase activity increases in serum of animal intoxicated by aflatoxins (group B)
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the activity of isozyme ADA2 is increased in individuals with cancer
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adenosine deaminase activity is significantly higher in patients with renal cell carcinoma than in controls
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enzyme activity is not significantly different between patients with fibromyalgia syndrome and controls
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adenosine deaminase activity increases in brain of animal intoxicated by aflatoxins (group B)
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the enzyme activity is highest in tuberculous meningitis patients, followed by non-infectious meningitis patients and healthy persons, the latter showing the lowest activity
apparent activity difference between healthy and hepatoma mice
from Friesian male cattle. Activity increases on day 100 post-infection (with Fasciola hepatica) contributed to the intense inflammatory process and oxidative damage due to the depletion of adenosine levels, an antiinflammatory molecule
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adenosine deaminase activity increases in liver of animal intoxicated by aflatoxins (group B)
ADA2 is secreted by promonocytic cell lines and blood monocytes differentiated into macrophages and dendritic cells
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trophoblast, enzyme activity and its isoenzyme pattern in women with recurrent spontaneous abortions
