3.5.4.4: adenosine deaminase
This is an abbreviated version!
For detailed information about adenosine deaminase, go to the full flat file.
Word Map on EC 3.5.4.4
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3.5.4.4
-
purine
-
nucleoside
-
lymphocyte
-
immunodeficiency
-
inosine
-
pleural
-
tuberculous
-
deamination
-
effusion
-
erythrocyte
-
phosphorylase
-
agonist
-
leukemia
-
5'-nucleotidase
-
deoxyadenosine
-
marrow
-
xanthine
-
adenylate
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hypoxanthine
-
t-cells
-
lymphoid
-
ehna
-
dipyridamole
-
purinergic
-
hematopoietic
-
exudative
-
lipolysis
-
pleurisy
-
meningitis
-
theophylline
-
datp
-
ecto-5\'-nucleotidase
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s-adenosylhomocysteine
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2-chloroadenosine
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dpcpx
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autoinflammatory
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pericarditis
-
acid-fast
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deoxycytidine
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transudate
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antilipolytic
-
diphosphohydrolase
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hypoxanthine-guanine
-
adenosine-induced
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ectonucleotidases
-
n6-cyclopentyladenosine
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empyema
-
deaminases
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ntpdases
-
purinoceptors
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medicine
-
pharmacology
-
drug development
-
diagnostics
-
analysis
- 3.5.4.4
- purine
- nucleoside
- lymphocyte
- immunodeficiency
- inosine
- pleural
-
tuberculous
-
deamination
- effusion
- erythrocyte
- phosphorylase
- agonist
- leukemia
- 5'-nucleotidase
- deoxyadenosine
- marrow
- xanthine
- adenylate
- hypoxanthine
- t-cells
-
lymphoid
- ehna
- dipyridamole
-
purinergic
-
hematopoietic
-
exudative
-
lipolysis
- pleurisy
- meningitis
- theophylline
- datp
-
ecto-5\'-nucleotidase
- s-adenosylhomocysteine
- 2-chloroadenosine
- dpcpx
-
autoinflammatory
- pericarditis
-
acid-fast
- deoxycytidine
-
transudate
-
antilipolytic
-
diphosphohydrolase
-
hypoxanthine-guanine
-
adenosine-induced
- ectonucleotidases
-
n6-cyclopentyladenosine
- empyema
- deaminases
- ntpdases
-
purinoceptors
- medicine
- pharmacology
- drug development
- diagnostics
- analysis
Reaction
Synonyms
AD, ADA, ADA1, ADA2, ADAI, ADAII, ADAIII, Adenosine aminohydrolase, adenosine deaminase, adenosine deaminase 1, adenosine deaminase 2, ciADA, HadA, LADA, MadA, MJ1541, PvADA, SADA, SCO4901, TadA
ECTree
3.5.4.4 adenosine deaminaseAdvanced search results
results (
results (Specific Activity
Specific Activity on EC 3.5.4.4 - adenosine deaminase
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SPECIFIC ACTIVITY [µmol/min/mg] 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
0.12
0.5
0.9
120
-
crude cell extract, pH 7.5, temperature not specified in the publication
2
enzymatic data, conformational properties and docking scores for adenosine analogue 2,3-O-methoxymethylideneadenosine, modeling studies
760
-
crude cell extract, pH 7.5, temperature not specified in the publication
additional information
0.9
enzymatic data, conformational properties and docking scores for adenosine analogue 2,3-O-isopropylidenadenosine, modeling studies
additional information
no activity with substrate 9H-(1-deoxy-3,4-O-isopropylidene-beta-D-psicofuranosyl)adenine, adenosine deaminase aptly transforms substrates largely modified at the 2- and 3-O-positions, whereas C-modification at the 1-position prevents the adenosine deaminase-catalyzed deamination
additional information
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the serum adenosine deaminase activity increases significantly in all infected groups compared to control group (adenosine deaminase activity: 5.99 IU/l control group, 27.62 IU/l infected group)
additional information
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relative substrate specificity in nmol NH3/min/mg of protein, adenosine 11.2, 2-deoxyadenosine 23.6, guanosine 1.8, 2-deoxyguanosine 2.0 for the soluble fraction, adenosine 20.9, 2-deoxyadenosine 5.4, guanosine 1.7, 2-deoxyguanosine 1.8 for the membrane-bound adenosine deaminase
additional information
the adenosine deaminase activity level is highest at day 1 in all the regions of chicken gastrointestinal tract and could be reduced or enhanced by corticosterone and dibutyryl cAMP, respectively, in an age-specific manner
additional information
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the adenosine deaminase activity level is highest at day 1 in all the regions of chicken gastrointestinal tract and could be reduced or enhanced by corticosterone and dibutyryl cAMP, respectively, in an age-specific manner
additional information
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activity in cerebrospinal fluid of healthy persons and tuberculous or non-infectious meningitis patients
additional information
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enzyme activity in T-lymphocytes of healthy persons and multiple sclerosis patients
additional information
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patients with fever attack have significantly higher adenosine deaminase levels in plasma compared to attack-free periods and healthy control group
additional information
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tADA and ADA2 levels are higher in patients with Chronic Granulomatous Disease (CGD), Leukocyte Adhesion Deficiency (LAD), hyper IgM (HIM) and Wiskott-Aldrich Syndrome (WAS) than those of corresponding controls. There is a significant elevation of tADA and ADA1 activities in IgA deficiency patients as compared to healthy individuals
additional information
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adenosine deaminase activity is higher in young rat brains when compared to the 60-day-old rats and is higher in hippocampus when compared to the cerebral cortex
additional information
326 nkat/mg with substrate adenine, reaction of EC 3.5.4.2, adenine deaminase
additional information
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326 nkat/mg with substrate adenine, reaction of EC 3.5.4.2, adenine deaminase
additional information
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ADA activity is observed in the parasites at all concentrations tested and its activity is proportional to the concentration of protein, ranging between 0.64 and 2.24 U/l in the lowest and highest concentration of protein, respectively
