Protein Variants | Comment | Organism |
---|---|---|
additional information | ADA-deficiency in mice inhibits the further differentiation of double positive CD4+CD8+ thymocytes in fetal thymic organ culture, the later stages of thymocyte development are sensitive to a lack of ADA, the block is mediated by a mitochondria-dependent mechanism. ADA-deficient cultures are partially rescued by the pan-caspase inhibitor carbobenzoxy-Val-Ala-Asp-fluoromethyl ketone or by the use of Apaf-1-deficient mice lacking apoptotic protease-activating factor-1, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-deoxycoformycin | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine + H2O | Mus musculus | the enzyme is important in thymocyte development, especially in late stages, overview | inosine + NH3 | - |
? | |
adenosine + H2O | Mus musculus C57BL/6 | the enzyme is important in thymocyte development, especially in late stages, overview | inosine + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thymus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine + H2O | - |
Mus musculus | inosine + NH3 | - |
? | |
adenosine + H2O | the enzyme is important in thymocyte development, especially in late stages, overview | Mus musculus | inosine + NH3 | - |
? | |
adenosine + H2O | - |
Mus musculus C57BL/6 | inosine + NH3 | - |
? | |
adenosine + H2O | the enzyme is important in thymocyte development, especially in late stages, overview | Mus musculus C57BL/6 | inosine + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADA | - |
Mus musculus |