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Literature summary for 3.5.4.4 extracted from
- A study on the inhibition of adenosine deaminase (2008), J. Enzyme Inhib. Med. Chem., 23, 182-189.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Aminopurine | competitive inhibition | Bos taurus |  |
| 4-aminopyridine | competitive inhibition | Bos taurus | |
| 4-aminopyrimidine | competitive inhibition | Bos taurus | |
| 4-hydroxypyridine | competitive inhibition | Bos taurus | |
| adenine | competitive inhibition | Bos taurus | |
| Inosine | competitive inhibition | Bos taurus | |
| phenylhydrazine | competitive inhibition | Bos taurus | |
| purine | competitive inhibition | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine + H2O | Bos taurus | - |
inosine + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | from spleen | Bos taurus | - |
| spleen | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 60 | 130 | purified commercial preparation from spleen | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine + H2O | - |
Bos taurus | inosine + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADA | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Bos taurus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics | Bos taurus | |
| 0.17 | - |
adenine | pH 7.5, 25°C | Bos taurus | |
| 0.25 | - |
phenylhydrazine | pH 7.5, 25°C | Bos taurus | |
| 0.33 | - |
2-Aminopurine | pH 7.5, 25°C | Bos taurus | |
| 0.35 | - |
Inosine | pH 7.5, 25°C | Bos taurus | |
| 1.1 | - |
purine | pH 7.5, 25°C | Bos taurus | |
| 1.3 | - |
4-aminopyrimidine | pH 7.5, 25°C | Bos taurus | |
| 1.4 | - |
4-hydroxypyridine | pH 7.5, 25°C | Bos taurus | |
| 1.8 | - |
4-aminopyridine | pH 7.5, 25°C | Bos taurus | |
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Release 2023.1 (January 2023)
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