3.5.1.19: nicotinamidase
This is an abbreviated version!
For detailed information about nicotinamidase, go to the full flat file.
Word Map on EC 3.5.1.19
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3.5.1.19
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mycobacterium
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tuberculosis
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pyrazinamide
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pyrazinoic
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pza-resistant
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bactec
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pyrazinamide-resistant
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sir2-dependent
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kansasii
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wayne
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sir2-mediated
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pza-susceptible
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analysis
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drug development
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medicine
- 3.5.1.19
- mycobacterium
- tuberculosis
- pyrazinamide
-
pyrazinoic
-
pza-resistant
-
bactec
-
pyrazinamide-resistant
-
sir2-dependent
- kansasii
-
wayne
-
sir2-mediated
-
pza-susceptible
- analysis
- drug development
- medicine
Reaction
Synonyms
AS87_01735, ASAC_0847, NAAA, NA_As0847, NIC, nicotinamidase, nicotinamidase PNC-1, nicotinamidase Pnc1p, nicotinamidase PncA, nicotinamidase/pyrazinamidase, nicotinamidase/pyrazinamidase PncA, nicotinamide amidase, nicotinamide deaminase, Nicotine deamidase, OiNIC, PNC-1, Pnc1, Pnc1p, PNC2, PncA, polygenomic nicotinamidase, PolyNic, pyrazinamidase, PZAase, PZAse, SpNic, TTHA0328, UbNic, YNDase
ECTree
3.5.1.19 nicotinamidaseAdvanced search results
results (
results (KCat KM Value
KCat KM Value on EC 3.5.1.19 - nicotinamidase
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kcat/KM VALUE [1/mMs-1] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0086
1-methylnicotinamide
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
0.05
Thionicotinamide
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
3.4
5-methyl nicotinamide
recombinant mutant Q96K, pH 7.3, 37°C
7.5
5-methyl nicotinamide
recombinant wild-type enzyme, pH 7.3, 37°C
11.07
5-methyl nicotinamide
recombinant mutant C133A, pH 7.3, 37°C
29.04
5-methyl nicotinamide
recombinant mutant Q96A, pH 7.3, 37°C
0.061
5-Methylnicotinamide
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
18.5
5-Methylnicotinamide
37°C, pH 7.3, mutant enzyme W83F
18.9
5-Methylnicotinamide
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pH 7.3, temperature not specified in the publication
29
5-Methylnicotinamide
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
35
5-Methylnicotinamide
37°C, pH 7.3, mutant enzyme H75E
40.1
5-Methylnicotinamide
37°C, pH 7.3, wild-type enzyme
45.7
5-Methylnicotinamide
37°C, pH 7.3, mutant enzyme A151C
53.9
5-Methylnicotinamide
37°C, pH 7.3, mutant enzyme H75S
0.025
Benzamide
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
0.35
Benzamide
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
0.1
ethyl nicotinate
recombinant wild-type enzyme, pH 7.3, 37°C
0.1
ethylnicotinate
37°C, pH 7.3, mutant enzyme W83F
0.2
ethylnicotinate
37°C, pH 7.3, mutant enzyme H75E
0.2
ethylnicotinate
37°C, pH 7.3, mutant enzyme H75S
0.3
ethylnicotinate
37°C, pH 7.3, mutant enzyme A151C
0.31
methyl nicotinate
recombinant wild-type enzyme, pH 7.3, 37°C
1.14
methyl nicotinate
recombinant mutant C133A, pH 7.3, 37°C
1.4
methylnicotinate
37°C, pH 7.3, mutant enzyme W83F
2.8
methylnicotinate
37°C, pH 7.3, mutant enzyme H75S
14.1
methylnicotinate
37°C, pH 7.3, mutant enzyme H75E
20.5
methylnicotinate
37°C, pH 7.3, mutant enzyme A151C
50.5
methylnicotinate
37°C, pH 7.3, wild-type enzyme
0.0096
nicotinamide
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
2.2
nicotinamide
mutant enzyme H53A, in 50 mM sodium phosphate (pH 7.5), at 25°C
6.7
nicotinamide
kcat/Km above 6.7 (1/sec*mM), mutant enzyme K122A, in 50 mM sodium phosphate (pH 7.5), at 25°C
7.4
nicotinamide
kcat/Km above 7.4 (1/sec*mM), mutant enzyme H94A, in 50 mM sodium phosphate (pH 7.5), at 25°C
8.3
nicotinamide
kcat/Km above 8.3 (1/sec*mM), mutant enzyme D51A, in 50 mM sodium phosphate (pH 7.5), at 25°C
35
nicotinamide
kcat/Km above 35 (1/sec*mM), mutant enzyme D51N, in 50 mM sodium phosphate (pH 7.5), at 25°C
37
nicotinamide
-
mutant enzyme H57D, in 100 mM HEPES at pH 8.0 and 25°C
43.48
nicotinamide
recombinant wild-type enzyme, pH 7.3, 37°C
52.8
nicotinamide
recombinant mutant F68W/C133A, pH 7.3, 37°C
72
nicotinamide
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
220
nicotinamide
-
wild type enzyme, in 100 mM HEPES at pH 8.0 and 25°C
427
nicotinamide
pH and temperature not specified in the publication
3000
nicotinamide
pH and temperature not specified in the publication
0.157
Pyrazinamide
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
6.2
Pyrazinamide
-
mutant enzyme H57D, in 100 mM HEPES at pH 8.0 and 25°C
6.28
Pyrazinamide
recombinant mutant F68W/C133A, pH 7.3, 37°C
13
Pyrazinamide
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wild type enzyme, in 100 mM HEPES at pH 8.0 and 25°C
16
Pyrazinamide
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
34.1
Pyrazinamide
37°C, pH 7.3, mutant enzyme A151C
