3.5.1.19: nicotinamidase
This is an abbreviated version!
For detailed information about nicotinamidase, go to the full flat file.
Word Map on EC 3.5.1.19
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3.5.1.19
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mycobacterium
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tuberculosis
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pyrazinamide
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pyrazinoic
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pza-resistant
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bactec
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pyrazinamide-resistant
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sir2-dependent
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kansasii
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wayne
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sir2-mediated
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pza-susceptible
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analysis
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drug development
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medicine
- 3.5.1.19
- mycobacterium
- tuberculosis
- pyrazinamide
-
pyrazinoic
-
pza-resistant
-
bactec
-
pyrazinamide-resistant
-
sir2-dependent
- kansasii
-
wayne
-
sir2-mediated
-
pza-susceptible
- analysis
- drug development
- medicine
Reaction
Synonyms
AS87_01735, ASAC_0847, NAAA, NA_As0847, NIC, nicotinamidase, nicotinamidase PNC-1, nicotinamidase Pnc1p, nicotinamidase PncA, nicotinamidase/pyrazinamidase, nicotinamidase/pyrazinamidase PncA, nicotinamide amidase, nicotinamide deaminase, Nicotine deamidase, OiNIC, PNC-1, Pnc1, Pnc1p, PNC2, PncA, polygenomic nicotinamidase, PolyNic, pyrazinamidase, PZAase, PZAse, SpNic, TTHA0328, UbNic, YNDase
ECTree
3.5.1.19 nicotinamidaseAdvanced search results
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results (KI Value
KI Value on EC 3.5.1.19 - nicotinamidase
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Ki VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.316
3-acetylpyridine
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
0.00029
3-pyridine carboxaldehyde
-
wild type enzyme, in 100 mM HEPES at pH 8.0 and 25°C
0.000023
5-methylnicotinaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.0206
benzaldehyde
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
6.7
pyrazinoic acid
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
0.1
pyridine-3-carbonitrile
-
Ki about 0.1 mM, wild type enzyme, in 100 mM HEPES at pH 8.0 and 25°C
0.37
2-chloropyridine-3-carbaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
5
2-chloropyridine-3-carbaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.00044
4-methoxylnicotinaldehyde
-
isoform PNC2, in 100 mM phosphate buffer, pH 7.3 at 25°C
0.001
4-methoxylnicotinaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.05
4-methoxylnicotinaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.068
4-methoxylnicotinaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.153
4-methoxylnicotinaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.00007
5-bromonicotinaldehyde
-
pH 7.3, temperature not specified in the publication, substrate: pyrazinamide
0.0044
5-bromonicotinaldehyde
recombinant wild-type enzyme, pH 7.3, 37°C
0.00059
5-bromopyridine-3-carbaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.004
5-bromopyridine-3-carbaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.000039
5-methoxypyridine-3-carbaldehyde
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in 100 mM phosphate buffer, pH 7.3 at 25°C
0.000056
5-methoxypyridine-3-carbaldehyde
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in 100 mM phosphate buffer, pH 7.3 at 25°C
0.00014
5-methoxypyridine-3-carbaldehyde
-
isoform PNC2, in 100 mM phosphate buffer, pH 7.3 at 25°C
0.00031
5-methoxypyridine-3-carbaldehyde
-
isoform PNC1, in 100 mM phosphate buffer, pH 7.3 at 25°C
0.00085
5-methoxypyridine-3-carbaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.0038
5-methoxypyridine-3-carbaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.000023
5-methylpyridine-3-carbaldehyde
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in 100 mM phosphate buffer, pH 7.3 at 25°C
0.00019
5-methylpyridine-3-carbaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.00065
5-methylpyridine-3-carbaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.004
6-fluoropyridine-3-carbaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.018
6-fluoropyridine-3-carbaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.000011
nicotinaldehyde
-
in 100 mM phosphate buffer, pH 7.3 at 25°C
0.000015
nicotinaldehyde
-
pH 7.3, temperature not specified in the publication, substrate: pyrazinamide
0.000022
nicotinaldehyde
-
isoform PNC2, in 100 mM phosphate buffer, pH 7.3 at 25°C
0.00011
nicotinaldehyde
-
isoform PNC1, in 100 mM phosphate buffer, pH 7.3 at 25°C
0.00094
nicotinaldehyde
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
0.0035
nicotinaldehyde
recombinant wild-type enzyme, pH 7.3, 37°C
0.12
nicotinic acid
wild type enzyme, in 50 mM sodium phosphate (pH 7.5), at 25°C
