3.5.1.19: nicotinamidase
This is an abbreviated version!
For detailed information about nicotinamidase, go to the full flat file.
Word Map on EC 3.5.1.19
-
3.5.1.19
-
mycobacterium
-
tuberculosis
-
pyrazinamide
-
pyrazinoic
-
pza-resistant
-
bactec
-
pyrazinamide-resistant
-
sir2-dependent
-
kansasii
-
wayne
-
sir2-mediated
-
pza-susceptible
-
analysis
-
drug development
-
medicine
- 3.5.1.19
- mycobacterium
- tuberculosis
- pyrazinamide
-
pyrazinoic
-
pza-resistant
-
bactec
-
pyrazinamide-resistant
-
sir2-dependent
- kansasii
-
wayne
-
sir2-mediated
-
pza-susceptible
- analysis
- drug development
- medicine
Reaction
Synonyms
AS87_01735, ASAC_0847, NAAA, NA_As0847, NIC, nicotinamidase, nicotinamidase PNC-1, nicotinamidase Pnc1p, nicotinamidase PncA, nicotinamidase/pyrazinamidase, nicotinamidase/pyrazinamidase PncA, nicotinamide amidase, nicotinamide deaminase, Nicotine deamidase, OiNIC, PNC-1, Pnc1, Pnc1p, PNC2, PncA, polygenomic nicotinamidase, PolyNic, pyrazinamidase, PZAase, PZAse, SpNic, TTHA0328, UbNic, YNDase
ECTree
3.5.1.19 nicotinamidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.5.1.19 - nicotinamidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
pyridine-3-carbothioamide + H2O
?
-
44% activity compared to nicotinamide
-
-
?
4-methoxypyridine-3-carboxamide + H2O
?
-
20% activity compared to nicotinamide
-
-
?
4-methoxypyridine-3-carboxamide + H2O
?
-
12% activity compared to nicotinamide
-
-
?
4-methoxypyridine-3-carboxamide + H2O
?
-
5% activity compared to nicotinamide
-
-
?
4-methoxypyridine-3-carboxamide + H2O
?
-
6.5% activity compared to nicotinamide
-
-
?
5-methoxypyridine-3-carboxamide + H2O
?
-
221% activity compared to nicotinamide
-
-
?
5-methoxypyridine-3-carboxamide + H2O
?
-
646% activity compared to nicotinamide
-
-
?
5-methoxypyridine-3-carboxamide + H2O
?
-
206% activity compared to nicotinamide
-
-
?
5-methoxypyridine-3-carboxamide + H2O
?
-
137% activity compared to nicotinamide
-
-
?
5-methyl nicotinamide + H2O
5-methyl nicotinate + NH3
-
-
-
?
5-methyl nicotinamide + H2O
5-methyl nicotinate + NH3
-
-
-
?
5-methylnicotinamide + H2O
5-methylnicotinate + NH3
-
-
-
?
5-methylpyridine-3-carboxamide + H2O
?
-
51% activity compared to nicotinamide
-
-
?
5-methylpyridine-3-carboxamide + H2O
?
-
330% activity compared to nicotinamide
-
-
?
5-methylpyridine-3-carboxamide + H2O
?
-
80% activity compared to nicotinamide
-
-
?
5-methylpyridine-3-carboxamide + H2O
?
-
163% activity compared to nicotinamide
-
-
?
6-aminopyridine-3-carboxamide + H2O
?
-
45% activity compared to nicotinamide
-
-
?
6-aminopyridine-3-carboxamide + H2O
?
-
20% activity compared to nicotinamide
-
-
?
6-aminopyridine-3-carboxamide + H2O
?
-
36% activity compared to nicotinamide
-
-
?
6-chloropyridine-3-carboxamide + H2O
?
-
17% activity compared to nicotinamide
-
-
?
6-chloropyridine-3-carboxamide + H2O
?
-
1.8% activity compared to nicotinamide
-
-
?
6-methylpyridine-3-carboxamide + H2O
?
-
45% activity compared to nicotinamide
-
-
?
6-methylpyridine-3-carboxamide + H2O
?
-
40% activity compared to nicotinamide
-
-
?
6-methylpyridine-3-carboxamide + H2O
?
-
11% activity compared to nicotinamide
-
-
?
ethyl pyridine-3-carboxylate + H2O
?
-
2.3% activity compared to nicotinamide
-
-
?
ethyl pyridine-3-carboxylate + H2O
?
-
4.4% activity compared to nicotinamide
-
-
?
ethyl pyridine-3-carboxylate + H2O
?
-
0.86% activity compared to nicotinamide
-
-
?
methyl pyridine-3-carboxylate + H2O
?
-
6500% activity compared to nicotinamide
-
-
?
methyl pyridine-3-carboxylate + H2O
?
-
15% activity compared to nicotinamide
-
-
?
methyl pyridine-3-carboxylate + H2O
?
-
3.5% activity compared to nicotinamide
-
-
?
methylnicotinate + H2O
nicotinate + methanol
-
-
-
?
nicotinamide + H2O
nicotinate + NH3
the enzyme also catalyzes the hydrolysis of pyrazinamide
-
-
?
nicotinamide + H2O
nicotinate + NH3
the enzyme also catalyzes the hydrolysis of pyrazinamide
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
active site structure, overview
-
-
?
nicotinamide + H2O
nicotinate + NH3
binding structure involving residues A155, C159, and Ile154, and unbinding mechanism, modeling, overview
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
the enzyme is involved in degradation of nicotinamide
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
contributes to the intracellular replication and infectivity of Brucella abortus in mice
-
-
?
nicotinamide + H2O
nicotinate + NH3
Brucella abortus 544 / ATCC 23448
-
contributes to the intracellular replication and infectivity of Brucella abortus in mice
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
enzyme is induced at high nicotinamide concentrations
-
-
?
nicotinamide + H2O
nicotinate + NH3
preferred substrate
-
-
?
nicotinamide + H2O
nicotinate + NH3
preferred substrate
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
enzyme is involved in NAD+ biosynthesis
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
59.5% of the activity with pyrazinamide
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
59.5% of the activity with pyrazinamide
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
nicotinamidase is a key enzyme in the NAD+ salvage pathway
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
nicotinamidase is a key enzyme in the NAD+ salvage pathway
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
nicotinamide is a by-product of the Sir2 deacetylase reaction and is a natural Sir2 inhibitor, Pnc1, therefore, positively regulates Sir2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide during times of stress, PNC1 specifically prevents nicotinamide-induced inhibition of telomeric and rDNA silencing in vivo, overview, the enzyme is involved in the NAD+ biosynthesis and salvage, pathway overview
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
Pnc1 stimulates Sir2, an NAD+-dependent histone deacetylase, and prevents the accumulation of nicotinamide
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
-
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
the enzyme of the pyridine nucleotide cycle is not controlled by end-product repression
-
-
?
nicotinamide + H2O
nicotinate + NH3
binding structure and unbinding mechanism, modeling, overview
-
-
?
nicotinamide + H2O
nicotinate + NH3
key enzyme of the NAD+ salvage pathway
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
the enzyme is an essential component of the NAD+ salvage pathway
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
enzyme is involved in the pyridine nucleotide cycle
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
the enzyme is involved in the trigonelline biosynthesis
-
-
?
nicotinamide + H2O
nicotinate + NH3
-
assay with radiolabeled substrate
-
-
?
nicotinamide + H2O
nicotinic acid + NH3
-
as nicotinamide is an inhibitor of Arabidopsis seed germination, enzyme activity is important for germination
-
-
?
nicotinamide + H2O
nicotinic acid + NH3
-
enzyme involved in the NAD salvage pathway
-
-
?
phenyl pyridine-3-carboxylate + H2O
?
-
13% activity compared to nicotinamide
-
-
?
phenyl pyridine-3-carboxylate + H2O
?
-
3.1% activity compared to nicotinamide
-
-
?
phenyl pyridine-3-carboxylate + H2O
?
-
3.1% activity compared to nicotinamide
-
-
?
pyrazinamide + H2O
pyrazine-2-carboxylic acid + NH3
-
-
-
?
pyrazinamide + H2O
pyrazine-2-carboxylic acid + NH3
-
-
-
-
?
pyrazinamide + H2O
pyrazine-2-carboxylic acid + NH3
-
-
-
-
?
pyrazinamide + H2O
pyrazinoic acid + NH3
-
a nicotinamide prodrug. In Mycobacterium tuberculosis the enzyme converts the nicotinamide analogue prodrug pyrazinamide into the bacteriostatic pyrazinoic acid, hence the alternative name, pyrazinamidase, PncA
a bacteriostatic drug
-
?
pyrazinamide + H2O
pyrazinoic acid + NH3
-
the natural resistance of Mycobacterium kansasii to pyrazinamide is due to a deficient pyrazinamidase activity of nicotinamidase
-
-
?
pyrazinamide + H2O
pyrazinoic acid + NH3
residues Cys133 and Phe68 are critical for the pyraminidase activity
-
-
?
pyrazinamide + H2O
pyrazinoic acid + NH3
residues Cys133 and Phe68 are critical for the pyraminidase activity
-
-
?
additional information
?
-
no activity with N-carbamoylsarcosine, hydantoic acid, acrylamide, D- and L-asparagine, D- and L-glutamine
-
-
?
additional information
?
-
-
no activity with N-carbamoylsarcosine, hydantoic acid, acrylamide, D- and L-asparagine, D- and L-glutamine
-
-
?
additional information
?
-
no activity with N-carbamoylsarcosine, hydantoic acid, acrylamide, D- and L-asparagine, D- and L-glutamine
-
-
?
additional information
?
-
-
nicotinamidase cannot hydrolyze 1-methyl isonicotinamide
-
-
?
additional information
?
-
-
nicotinamidase cannot hydrolyze 1-methylisonicotinamide
-
-
?
additional information
?
-
-
nicotinamidase cannot hydrolyze 1-methyl isonicotinamide
-
-
?
additional information
?
-
-
nicotinamidase cannot hydrolyze 1-methyl isonicotinamide
-
-
?
additional information
?
-
no activity with nicotinamide mononucleotide and NAD+
-
-
?
additional information
?
-
-
no activity with nicotinamide mononucleotide and NAD+
-
-
?
additional information
?
-
-
nicotinamidase cannot hydrolyze 1-methylisonicotinamide
-
-
?
additional information
?
-
-
changes in trigonelline content and nicotinic acid metabolism during germination, overview
-
-
?
