3.5.1.19: nicotinamidase

This is an abbreviated version!
For detailed information about nicotinamidase, go to the full flat file.

Reaction

Synonyms

AS87_01735, ASAC_0847, NAAA, NA_As0847, NIC, nicotinamidase, nicotinamidase PNC-1, nicotinamidase Pnc1p, nicotinamidase PncA, nicotinamidase/pyrazinamidase, nicotinamidase/pyrazinamidase PncA, nicotinamide amidase, nicotinamide deaminase, Nicotine deamidase, OiNIC, PNC-1, Pnc1, Pnc1p, PNC2, PncA, polygenomic nicotinamidase, PolyNic, pyrazinamidase, PZAase, PZAse, SpNic, TTHA0328, UbNic, YNDase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.19 nicotinamidase

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Results	in table
10	Activating Compound
4445	AA Sequence
7	Application
1	CAS Registry Number
28	Cloned(Commentary)
7	Crystallization (Commentary)
39	General Information
4	General Stability
150	Inhibitors
79	kcat/KM [mM/s]
45	Ki Value [mM]
97	KM Value [mM]
14	Localization
30	Metals/Ions
29	Molecular Weight [Da]
96	Natural Substrates/ Products (Substrates)
281	Organism
1	Oxidation Stability
8	Pathway
36	PDB ID
25	pH Optimum
10	pH Range
5	pH Stability
1	Posttranslational Modification
48	Protein Variants
29	Purification (Commentary)
3	Reaction
1	Reaction Type
76	Reference
19	Source Tissue
42	Specific Activity [micromol/min/mg]
4	Storage Stability
185	Substrates and Products (Substrate)
31	Subunits
69	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
9	Temperature Range [°C]
23	Temperature Stability [°C]
85	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.5.1.19 - nicotinamidase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 10

Oryctolagus cuniculus

-

37°C, 1 h, stable

246570

5 - 9.5

uncultured Acidobacteria bacterium

H5SPS2

very stable nicotinamidase from acid (pH 5.0) to basic pHs (up to pH 9.5). Its stability is higher in sodium phosphate pH 7.3 and in glycine pH 9.5, maintaining 90% activity after 24 hours of incubation at such pHs. At lower pH values, the enzyme is less stable. It maintains 75% activity in sodium acetate pH 5.0 and pH 6.0 after 24 hours

755150

6 - 7.3

Oceanobacillus iheyensis

Q8ESQ6

purified recombinant wild-type enzyme, very stable at pH 6.0 and pH 7.3, where it maintains 40% and 30% residual activity, respectively, after 20 hours of incubation

735084

6 - 8

Mycobacterium tuberculosis

-

-

679806

7 - 9.5

Micrococcus luteus

-

37°C, 10 min, stable

246573