3.5.1.19: nicotinamidase
This is an abbreviated version!
For detailed information about nicotinamidase, go to the full flat file.
Word Map on EC 3.5.1.19
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3.5.1.19
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mycobacterium
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tuberculosis
-
pyrazinamide
-
pyrazinoic
-
pza-resistant
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bactec
-
pyrazinamide-resistant
-
sir2-dependent
-
kansasii
-
wayne
-
sir2-mediated
-
pza-susceptible
-
analysis
-
drug development
-
medicine
- 3.5.1.19
- mycobacterium
- tuberculosis
- pyrazinamide
-
pyrazinoic
-
pza-resistant
-
bactec
-
pyrazinamide-resistant
-
sir2-dependent
- kansasii
-
wayne
-
sir2-mediated
-
pza-susceptible
- analysis
- drug development
- medicine
Reaction
Synonyms
AS87_01735, ASAC_0847, NAAA, NA_As0847, NIC, nicotinamidase, nicotinamidase PNC-1, nicotinamidase Pnc1p, nicotinamidase PncA, nicotinamidase/pyrazinamidase, nicotinamidase/pyrazinamidase PncA, nicotinamide amidase, nicotinamide deaminase, Nicotine deamidase, OiNIC, PNC-1, Pnc1, Pnc1p, PNC2, PncA, polygenomic nicotinamidase, PolyNic, pyrazinamidase, PZAase, PZAse, SpNic, TTHA0328, UbNic, YNDase
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Reference on EC 3.5.1.19 - nicotinamidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shibata, K.; Hayakawa, T.; Iwai, K.
Tissue distribution of the enzymes concerned with the biosynthesis of NAD in rats
Agric. Biol. Chem.
50
3037-3041
1986
Rattus norvegicus
-
Foster, J.W.; Brestel, C.
NAD metabolism in Vibrio cholerae
J. Bacteriol.
149
368-371
1982
Vibrio cholerae serotype O1
Sarma, D.S.; Rajalakshmi, S.; Sarma, P.
Studies on the enzymes involved in nicotinamide adenine dinucleotide metabolism in Aspergillus niger
Biochim. Biophys. Acta
81
311-322
1964
Aspergillus niger
-
Petrack, B.; Greengard, P.; Craston, N.; Sheppy, F.
Nicotinamide deaminase from mammalian liver
J. Biol. Chem.
240
1725-1730
1965
Oryctolagus cuniculus, Rattus norvegicus
Pardee, B.P.
Hyperproduction and purification of nicotinamide deamidase, a microconstitutive enzyme of Escherichia coli
J. Biol. Chem.
246
6792-6796
1971
Escherichia coli
Albizati, L.D.; Hedrick, J.L.
Active-site studies on rabbit liver nicotinamide deamidase
Biochemistry
11
1508-1516
1972
Oryctolagus cuniculus
Tanigawa, J.; Shimiyama, M.; Dohi, K.; Ueda, I.
Purification and properties of nicotinamide deamidase from Flavobacterium peregrinum
J. Biol. Chem.
247
8036-8042
1972
Flavobacterium peregrinum
Gillam, S.S.; Watson, J.G.; Chaykin, S.
Nicotinamide deamidase from rabbit liver. 3. Inhibition and sedimentation studies
Arch. Biochem. Biophys.
157
268-284
1973
Oryctolagus cuniculus
Gadd, R.E.A.; Johson, W.J.
Kinetic studies of nicotinamide deaminase from Micrococcus lysodeikticus
Int. J. Biochem.
5
397-407
1974
Micrococcus luteus
-
Johnson, W.J.; Gadd, R.E.A.
Inhibition of nicotinamide deaminase from Micrococcus lysodeikticus by analogues of nicotinamide
Int. J. Biochem.
5
633-641
1974
Micrococcus luteus
-
Foster, W.J.; Kinney, D.M.; Moat, A.G.
Pyridine nucleotide cycle of Salmonella typhimurium: regulation of nicotinic acid phosphoribosyltransferase and nicotinamide deamidase
J. Bacteriol.
138
957-961
1979
Salmonella enterica subsp. enterica serovar Typhimurium
Wintzerith, M.; Dierich, A.; Mandel, P.
Purification and characterization of a nicotinamide deamidase released into the growth medium of neuroblastoma in vitro
Biochim. Biophys. Acta
613
191-202
1980
Mus musculus
Fuller, L.
Determination of nicotinamide
Methods Enzymol.
66
3-4
1980
Saccharomyces cerevisiae
-
Tanigawa, Y.; Shimiyama, M.; Ueda, I.
Nicotinamide deamidase from Flavobacterium peregrinum
Methods Enzymol.
66
132-136
1980
Flavobacterium peregrinum
Yan, C.; Sloan, D.L.
Purification and characterization of nicotinamide deamidase from yeast
J. Biol. Chem.
262
9082-9087
1987
Saccharomyces cerevisiae
Frothingham, R.; Meeker-OæConnell, W.A.; Talbot, E.A.S.; George, J.W.; Kreuzer K.N.
Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA
Antimicrob. Agents Chemother.
40
1426-1431
1996
Escherichia coli
Sun, Z.; Zhang, Y.
Reduced pyrazinamidase activity and the natural resistance of Mycobacterium kansasii to the antituberculois drug pyrazinamide
Antimicrob. Agents Chemother.
43
537-542
1999
Mycobacterium kansasii
Guo, M.; Sun, Z.; Zhang, Y.
Mycobacterium smegmatis has two pyrazinamidase enzymes PncA and PzaA
J. Bacteriol.
182
3881-3884
2000
Mycolicibacterium smegmatis
Boshoff, H.I.; Mizrahi, V.
Purification, gene cloning, targeted knockout, overexpression, and biochemical characterization of the major pyrazinamidase from Mycobacterium smegmatis
J. Bacteriol.
180
5809-5814
1998
Mycobacterium tuberculosis, Mycolicibacterium smegmatis
Zrez, C.R.; Roth, E.F.; Schulman, S.; Tanaka, K.R.
Increased nicotinamideadenine dinucleotide content and synthesis in Plasmodium falciparum - infected human erythrocytes
Blood
75
1705-1710
1990
Plasmodium falciparum
Raynaud, C.; Etienne, G.; Peyron, P.; Laneelle, M.A.; Daffe, M.
Extracellular enzyme activities potentially involved in the pathogenicity of Mycobacterium tuberculosis
Microbiology
144
577-587
1998
Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis, Mycolicibacterium fortuitum, Mycobacterium kansasii, Mycolicibacterium phlei
-
Kgayama, T.; Ohe, T.
Purification and properties of an aromatic amidase from Pseudomonas sp. GDI 211
Agric. Biol. Chem.
54
2565-2571
1990
Pseudomonas sp., Pseudomonas sp. GDI 211
-
Zheng, X.Q.; Hayashibe, E.; Ashihara, H.
Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mungbean (Phaseolus aureus) seeds
J. Exp. Bot.
56
1615-1623
2005
Vigna radiata var. radiata
Kim, S.; Kurokawa, D.; Watanabe, K.; Makino, S.i.; Shirahata, T.; Watarai, M.
Brucella abortus nicotinamidase (PncA) contributes to its intracellular replication and infectivity in mice
FEMS Microbiol. Lett.
234
289-295
2004
Brucella abortus, Brucella abortus 544 / ATCC 23448
Gallo, C.M.; Smith, D.L.; Smith, J.S.
Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity
Mol. Cell. Biol.
24
1301-1312
2004
Saccharomyces cerevisiae
Hu, G.; Taylor, A.B.; McAlister-Henn, L.; Hart, P.J.
Crystal structure of the yeast nicotinamidase Pnc1p
Arch. Biochem. Biophys.
461
66-75
2007
Saccharomyces cerevisiae (P53184), Saccharomyces cerevisiae
Zhang, H.; Deng, J.Y.; Bi, L.J.; Zhou, Y.F.; Zhang, Z.P.; Zhang, C.G.; Zhang, Y.; Zhang, X.E.
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
FEBS J.
275
753-762
2008
Mycobacterium tuberculosis
van der Horst, A.; Schavemaker, J.M.; Pellis-van Berkel, W.; Burgering, B.M.
The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival
Mech. Ageing Dev.
128
346-349
2007
Caenorhabditis elegans
Wang, G.; Pichersky, E.
Nicotinamidase participates in the salvage pathway of NAD biosynthesis in Arabidopsis
Plant J.
49
1020-1029
2007
Arabidopsis thaliana
Hunt, L.; Holdsworth, M.J.; Gray, J.E.
Nicotinamidase activity is important for germination
Plant J.
51
341-351
2007
Arabidopsis thaliana
Chong, Z.Z.; Maiese, K.
Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways
Curr. Neurovasc. Res.
5
159-170
2008
Drosophila melanogaster
McClure, J.M.; Gallo, C.M.; Smith, D.L.; Matecic, M.; Hontz, R.D.; Buck, S.W.; Racette, F.G.; Smith, J.S.
Pnc1p-mediated nicotinamide clearance modifies the epigenetic properties of rDNA silencing in Saccharomyces cerevisiae
Genetics
180
797-810
2008
Saccharomyces cerevisiae
Balan, V.; Miller, G.S.; Kaplun, L.; Balan, K.; Chong, Z.Z.; Li, F.; Kaplun, A.; VanBerkum, M.F.; Arking, R.; Freeman, D.C.; Maiese, K.; Tzivion, G.
Life span extension and neuronal cell protection by Drosophila nicotinamidase
J. Biol. Chem.
283
27810-27819
2008
Drosophila melanogaster
Yin, Y.; Matsui, A.; Sakuta, M.; Ashihara, H.
Changes in pyridine metabolism profile during growth of trigonelline-forming Lotus japonicus cell cultures
Phytochemistry
69
2891-2898
2008
Lotus japonicus
Fyfe, P.; Rao, V.; Zemla, A.; Cameron, S.; Hunter, W.
Specificity and mechanism of Acinetobacter baumanii nicotinamidase: Implications for activation of the front-line tuberculosis drug pyrazinamide
Angew. Chem. Int. Ed. Engl.
48
9176-9179
2009
Acinetobacter baumannii
Vrablik, T.L.; Huang, L.; Lange, S.E.; Hanna-Rose, W.
Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans
Development
136
3637-3646
2009
Caenorhabditis elegans
French, J.B.; Cen, Y.; Vrablik, T.L.; Xu, P.; Allen, E.; Hanna-Rose, W.; Sauve, A.A.
Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism
Biochemistry
49
10421-10439
2010
Borreliella burgdorferi, Saccharomyces cerevisiae, Caenorhabditis elegans, Streptococcus pneumoniae, Plasmodium falciparum
French, J.B.; Cen, Y.; Sauve, A.A.; Ealick, S.E.
High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes
Biochemistry
49
8803-8812
2010
Streptococcus pneumoniae (A0A0H2UR34), Streptococcus pneumoniae
Seiner, D.R.; Hegde, S.S.; Blanchard, J.S.
Kinetics and inhibition of nicotinamidase from Mycobacterium tuberculosis
Biochemistry
49
9613-9619
2010
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Smith, B.C.; Anderson, M.A.; Hoadley, K.A.; Keck, J.L.; Cleland, W.W.; Denu, J.M.
Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae
Biochemistry
51
243-256
2012
Saccharomyces cerevisiae (P53184), Saccharomyces cerevisiae
Gazanion, E.; Seblova, V.; Votypka, J.; Vergnes, B.; Garcia, D.; Volf, P.; Sereno, D.
Leishmania infantum nicotinamidase is required for late-stage development in its natural sand fly vector, Phlebotomus perniciosus
Int. J. Parasitol.
42
323-327
2012
Leishmania infantum
Gazanion, E.; Garcia, D.; Silvestre, R.; Gerard, C.; Guichou, J.F.; Labesse, G.; Seveno, M.; Cordeiro-Da-Silva, A.; Ouaissi, A.; Sereno, D.; Vergnes, B.
The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation
Mol. Microbiol.
82
21-38
2011
Leishmania infantum, Leishmania infantum MHOM/MA/67/ITMAP-263
Stekhanova, T.N.; Bezsudnova, E.Y.; Mardanov, A.V.; Osipov, E.M.; Ravin, N.V.; Skryabin, K.G.; Popov, V.O.
Nicotinamidase from the thermophilic archaeon Acidilobus saccharovorans: structural and functional characteristics
Biochemistry
79
54-61
2014
Acidilobus saccharovorans (D9Q1R5), Acidilobus saccharovorans, Acidilobus saccharovorans DSM 16705 (D9Q1R5)
Stekhanova, T.N.; Bezsudnova, E.Y.; Mardanov, A.V.; Osipov, E.M.; Ravin, N.V.; Skryabin, K.G.; Popov, V.O.
Nicotinamidase from the thermophilic archaeon Acidilobus saccharovorans: structural and functional characteristics
Biochemistry (Moscow)
79
54-61
2014
Acidilobus saccharovorans (D9Q1R5), Acidilobus saccharovorans, Acidilobus saccharovorans DSM 16705 (D9Q1R5)
Ion, B.F.; Kazim, E.; Gauld, J.W.
A multi-scale computational study on the mechanism of Streptococcus pneumoniae nicotinamidase (SpNic)
Molecules
19
15735-15753
2014
Streptococcus pneumoniae
Zhang, J.L.; Zheng, Q.C.; Li, Z.Q.; Zhang, H.X.
Molecular dynamics simulations suggest ligands binding to nicotinamidase/pyrazinamidase
PLoS ONE
7
e39546
2012
Streptococcus pneumoniae (A0A0H2UR34), Acinetobacter baumannii (B0VA03)
Sanchez-Carron, G.; Garcia-Garcia, M.I.; Zapata-Perez, R.; Takami, H.; Garcia-Carmona, F.; Sanchez-Ferrer, A.
Biochemical and mutational analysis of a novel nicotinamidase from Oceanobacillus iheyensis HTE831
PLoS ONE
8
e56727
2013
Oceanobacillus iheyensis (Q8ESQ6), Oceanobacillus iheyensis HTE831 (Q8ESQ6), Oceanobacillus iheyensis HTE831
Rueda, D.; Sheen, P.; Gilman, R.H.; Bueno, C.; Santos, M.; Pando-Robles, V.; Batista, C.V.; Zimic, M.
Nicotinamidase/pyrazinamidase of Mycobacterium tuberculosis forms homo-dimers stabilized by disulfide bonds
Tuberculosis
94
644-648
2014
Mycobacterium tuberculosis (I6XD65), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (I6XD65)
Wang, X.; Liu, B.; Dou, Y.; Fan, H.; Wang, S.; Li, T.; Ding, C.; Yu, S.
The Riemerella anatipestifer AS87_01735 gene encodes nicotinamidase PncA, an important virulence factor
Appl. Environ. Microbiol.
82
5815-5823
2016
Riemerella anatipestifer, Riemerella anatipestifer Yb2
Shang, F.; Chen, J.; Wang, L.; Jin, L.; Zou, L.; Bu, T.; Dong, Y.; Ha, N.C.; Nam, K.H.; Quan, C.; Xu, Y.
Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis
Biochem. Biophys. Res. Commun.
503
2906-2911
2018
Bacillus velezensis (A0A223CGG0)
Zapata-Perez, R.; Garcia-Saura, A.G.; Jebbar, M.; Golyshin, P.N.; Sanchez-Ferrer, A.
Combined whole-cell high-throughput functional screening for identification of new nicotinamidases/pyrazinamidases in metagenomic/polygenomic libraries
Front. Microbiol.
7
1915
2016
uncultured bacterium, no activity in Homo sapiens, unidentified
Taniguchi, H.; Sungwallek, S.; Chotchuang, P.; Okano, K.; Honda, K.
A key enzyme of the NAD+ salvage pathway in Thermus thermophilus characterization of nicotinamidase and the impact of its gene deletion at high temperatures
J. Bacteriol.
199
e00359-17
2017
Thermus thermophilus (Q5SLG5), Thermus thermophilus
Zapata-Perez, R.; Martinez-Monino, A.B.; Garcia-Saura, A.G.; Cabanes, J.; Takami, H.; Sanchez-Ferrer, A.
Biochemical characterization of a new nicotinamidase from an unclassified bacterium thriving in a geothermal water stream microbial mat community
PLoS ONE
12
e0181561
2017
uncultured Acidobacteria bacterium (H5SPS2)
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