3.4.24.B9: ADAM9 endopeptidase
This is an abbreviated version!
For detailed information about ADAM9 endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.B9
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3.4.24.B9
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adams
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metastasis
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ectodomains
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metalloproteases
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alpha-secretase
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hb-egf
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medicine
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adam-15
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non-amyloidogenic
- 3.4.24.B9
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adams
- metastasis
- ectodomains
- metalloproteases
- alpha-secretase
- hb-egf
- medicine
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adam-15
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non-amyloidogenic
Reaction
proteolytic degradation of proteins =
Synonyms
a disintegrin and metalloproteinase domain 9, ADAM 9, ADAM metallopeptidase domain 9, ADAM-9, ADAM-9 sheddase, ADAM9, cellular disintegrin-related protein, M12.209, MDC, MDC-9, MDC9, MDC9/meltrin-gamma/ADAM9, meltrin gamma, meltrin-gamma, metallo protease desintegrin 9, metalloprotease ADAM9, metalloprotease disintegrin 9, metalloprotease/disintegrin/cysteine-rich protein 9, MLTNG, More, myeloma cell metalloproteinase
ECTree
3.4.24.B9 ADAM9 endopeptidaseAdvanced search results
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Source Tissue on EC 3.4.24.B9 - ADAM9 endopeptidase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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carotid and femoral arteries, only weak ADAM-9 expression from thyroid artery without atherosclerosis
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grade 3, CIN lesions are premalignant changes
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lung cancer cell line, enzyme mRNA levels are significantly higher in highly brain-metastatic sublines than in the parent or highly bone-metastatic sublines
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synovial membrane-like interface tissue is collected from the proximal bone-cement or bone-stem interfaces around aseptically loosened femoral stems
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cells secrete a alternatively spliced variant of enzyme promoting carcinoma invasion
expression of full length and short enzyme form, with higher level of the short form than in other tissues
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in advanced human atherosclerotic plaques of aorta and carotid and femoral arteries, high expression level
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ADAM-9 is expressed in human melanoma at the tumor-stroma border where direct or indirect interactions between tumor cells and fibroblasts occur
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stromal liver myofibroblast, enzyme expression particularly by cells localized within the tumor stroma at the invasive front
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recombinant enzyme promotes a fivefold increase in interleukin IL-6, but not IL-1beta mRNA. Enzyme binds directly to alphabeta5 integrin
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elevated level of enzyme in malignant compared to benign tissue. Increase in enzyme protein and mRNA upon exposure of prostate cells to stress conditions. Inhibition of stress-induction of enzyme by actinomycin D and cycloheximide
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in normal epithelium, CIN3 lesions, and squamous cell carcinomas
additional information
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prostate cancer cell, elevated level of enzyme during the transition of cells from androgen-dependent to androgen-independent and metastatic state. Induction of enzyme is abrogated by the antioxidant ebselen or the enzyme catalase
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study on expression patterns of enzymes ADAM9, ADAM10, and ADAM 17 during pancreas ontogeny. The three enzymes are expressed in the pancreas anlagen. During development, ADAM9 becomes restricted to the insulin-producing beta-cells
additional information
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study on several human skin melanoma and melanoma cell lines. In melanoma, enzyme expression is restricted to the melanoma cells within the invading front. Enzyme is detected in melanoma cells and in peritumoral stromal fibroblasts, but absent in fibroblasts distal to the tumor site. In melanoma cell lines, enzyme is expressed in varying amounts in all cell lines studied. Downregulation of enzyme expression upon culture of cells within 3-dimensional latticies of fibrillar type I collagen, but not in the polysaccharide alginate
additional information
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ADAM9 expression is low in the squamous epithelium of the cervix, but is increased in CIN3 lesions as well as squamous cell carcinomas, only weak expression of ADAM9 in the normal cervical epithelium
