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Literature summary for 3.4.24.B9 extracted from

  • Amour, A.; Knight, C.G.; English, W.R.; Webster, A.; Slocombe, P.M.; Knauper, V.; Docherty, A.J.; Becherer, J.D.; Blobel, C.P.; Murphy, G.
    The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs (2002), FEBS Lett., 524, 154-158.
    View publication on PubMed
Search for more literature for 3.4.24.B9

Activating Compound

Activating Compound Comment Organism Structure
Phorbol esters
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin 11% inhibition at 0.025 mM Homo sapiens
benzamidine 14% inhibition at 1 mM Homo sapiens
Hydroxamates metalloprotease inhibitors, derivatives FN-439, BB3103, BB 3241, and IC-3 Homo sapiens
additional information no inhibition by metalloprotease inhibitor TIMP-2 Homo sapiens
o-phenanthroline 91% inhibition at 0.1 mM Homo sapiens
phosphoramidon 4% inhibition at 0.01 mM Homo sapiens
TIMP-1 metalloprotease inhibitor, 11% inhibition at 0.0005 mM Homo sapiens
TIMP-3 metalloprotease inhibitor, 15% inhibition at 0.00015 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
79000
-
 x * 79000, processed mature enzyme, SDS-PAGE, x * 110000, enzyme proform, SDS-PAGE Homo sapiens
110000
-
 x * 79000, processed mature enzyme, SDS-PAGE, x * 110000, enzyme proform, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proteins + H2O Homo sapiens
-
 peptides
-
 ?
transmembrane collagen XVII + H2O Homo sapiens substrate protein is an endothelial adhesion molecule on the surface of keratinocytes, protein is shed from the cell surface soluble collagen ectodomain cells show altered motility ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification processing cleavage by furin Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte epidermis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proteins + H2O
-
 Homo sapiens peptides
-
 ?
transmembrane collagen XVII + H2O
-
 Homo sapiens soluble collagen
-
 ?
transmembrane collagen XVII + H2O substrate protein is an endothelial adhesion molecule on the surface of keratinocytes, protein is shed from the cell surface Homo sapiens soluble collagen ectodomain cells show altered motility ?

Subunits

Subunits Comment Organism
? x * 79000, processed mature enzyme, SDS-PAGE, x * 110000, enzyme proform, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ADAM-9
-
 Homo sapiens
M12.209 Merops-ID Homo sapiens