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Literature summary for 3.4.24.B9 extracted from
- Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays (2017), Biochem. J., 474, 1469-1479 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | ADAM9 does not respond to stimulation with phorbol esters, calcium ionophore or phosphatase inhibitors | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in COS-7 cell | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| batimastat | - |
Mus musculus |  |
| GM6001 | hydroxamate inhibitor | Mus musculus | |
| GW280264X | - |
Mus musculus | |
| marimastat | - |
Mus musculus | |
| additional information | not inhibitory: up to 20 nM of TIMP-1 or -2 | Mus musculus | |
| TAPI-2 | hydroxamate inhibitor | Mus musculus | |
| TIMP-3 | i.e. tissue inhibitor of metalloproteinases-3, inhibition at 10 nM | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q61072 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryonic fibroblast cell line | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ephrin receptor B4 + H2O | - |
Mus musculus | ? | - |
? | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00005 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | batimastat | |
| 0.00013 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | marimastat | |
| 0.00048 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | GW280264X | |
| 0.00072 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | GM6001 | |
| 0.0135 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | TAPI-2 | |
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