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Literature summary for 3.4.24.B9 extracted from

  • Wang, X.; Polverino, F.; Rojas-Quintero, J.; Zhang, D.; Sánchez, J.; Yambayev, I.; Lindqvist, E.; Virtala, R.; Djukanovic, R.; Davies, D.; Wilson, S.; ODonnell, R.; Cunoosamy, D.; Hazon, P.; Higham, A.; Singh, D.; Olsson, H.; Owen, C.
    A disintegrin and metalloproteinase domain-9 A novel proteinase culprit with multifarious contributions to chronic obstructive pulmonary disease (2018), Am. J. Respir. Crit. Care Med., 198, 1500-1518 .
No PubMed abstract available
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Application

Application Comment Organism
medicine ADAM9 staining is increased in lung epithelial cells and macrophages in smokers and even more so in patients with chronic obstructive pulmonary disease COPD. ADAM9 staining correlates directly with pack-year smoking history and inversely with airflow obstruction and/or FEV1 percent predicted. Bronchial epithelial cell ADAM9 mRNA levels are higher in patients with COPD than control subjects and correlate directly with pack-year smoking history Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13443
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
blood
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 Homo sapiens
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lung
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 Mus musculus
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lung
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function Adam9-/- mice are protected from emphysema development, small-airway fibrosis, and airway mucus metaplasia. Cigarette smoke-exposed Adam9-/- mice have reduced lung macrophage counts, alveolar septal cell apoptosis, lung elastin degradation, and shedding of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor in BAL fluid samples Mus musculus