3.4.24.B9: ADAM9 endopeptidase
This is an abbreviated version!
For detailed information about ADAM9 endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.B9
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3.4.24.B9
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adams
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metastasis
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ectodomains
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metalloproteases
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alpha-secretase
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hb-egf
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medicine
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adam-15
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non-amyloidogenic
- 3.4.24.B9
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adams
- metastasis
- ectodomains
- metalloproteases
- alpha-secretase
- hb-egf
- medicine
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adam-15
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non-amyloidogenic
Reaction
proteolytic degradation of proteins =
Synonyms
a disintegrin and metalloproteinase domain 9, ADAM 9, ADAM metallopeptidase domain 9, ADAM-9, ADAM-9 sheddase, ADAM9, cellular disintegrin-related protein, M12.209, MDC, MDC-9, MDC9, MDC9/meltrin-gamma/ADAM9, meltrin gamma, meltrin-gamma, metallo protease desintegrin 9, metalloprotease ADAM9, metalloprotease disintegrin 9, metalloprotease/disintegrin/cysteine-rich protein 9, MLTNG, More, myeloma cell metalloproteinase
ECTree
3.4.24.B9 ADAM9 endopeptidaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.24.B9 - ADAM9 endopeptidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
amyloid precursor protein + H2O
90-100 kDa non-amyloid N-terminal protein fragment
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alpha-secretase activity
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?
EVHHQKLVFFAE + H2O
EVHH + QKLVFFAE
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peptides derived from beta-amyloid precursor protein, comprises the predicted cleavage site
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?
heparin-binding EGF-like growth factor + H2O
heparin-binding EGF-like growth factor fragment
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cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding
soluble product
?
insulin B chain + H2O
3 peptides
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cleavage sites are Tyr16-Leu17 and Tyr26-Thr27
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?
Mca-PLAQAV-Dpa-RSSSR-NH2 + H2O
Mca-PLAQA + V-Dpa-RSSSR-NH2
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quenched fluorescent substrate
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?
SMAPGAVHLPQP + H2O
SMAPGAVH + LPQP
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peptides derived from P75 TNF-receptor, comprises the predicted cleavage site
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?
SPLAQAVRSSSR + H2O
SPLA + QAVRSSSR
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peptides derived from TNF-alpha, comprises the predicted cleavage site
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?
SPLAQAVRSSSR + H2O
SPLAQAVRS + SSR
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peptides derived from TNF-alpha, comprises the predicted cleavage site
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?
transmembrane collagen XVII + H2O
soluble collagen ectodomain
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substrate protein is an endothelial adhesion molecule on the surface of keratinocytes, protein is shed from the cell surface
cells show altered motility
?
amyloid precursor protein + H2O
?
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enzyme shows alpha-secretase activity
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?
amyloid precursor protein + H2O
?
enzyme shows alpha-secretase activity
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?
amyloid precursor protein + H2O
?
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enzyme shows alpha-secretase activity, the alpha-secretase might be composed of several ADAM enzymes in a complexe
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?
beta-casein + H2O
?
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recombinant metalloprotease domain is catalytically active against beta-casein
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?
Fibronectin + H2O
?
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recombinant metalloprotease domain is catalytically active against fibronectin
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?
Gelatin + H2O
?
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recombinant metalloprotease domain is catalytically active gelatin
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?
pro-heparin-binding EGF-like growth factor + H2O
?
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cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding
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?
proteins + H2O
peptides
enzymes of the ADAM family play importants roles in cell-cell fusion, intracellular signaling, and other cellular functions
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?
additional information
?
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interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme
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?
additional information
?
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the enzyme interacts in a RGD motif-independent manner with the alphaVbeta5-domain of integrins, e.g. on the surface of myeloma but not lymphoblastoid cells, dependent on cations Ca2+ or Mn2+
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?
additional information
?
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potential ADAM-9 sheddase substrates include growth factors and cytokines, which have been linked to atherosclerosis
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-
?
additional information
?
-
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ADAM-9 is capable of binding to alpha6beta1 and alphanubeta5 integrins
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?
additional information
?
-
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interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme
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?
additional information
?
-
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regulation of metalloprotease desintegrins via a cysteine-switch mechanism
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?
additional information
?
-
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enzyme can cleave and release epidermal growth factor and FGFR2iiib from cells
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?
additional information
?
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enzyme is a polyvalent ligand, through its disintegrin domain, for multiple renal integrins of the beta1 class
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?
