Literature summary for 3.4.24.B9 extracted from

Zigrino, P.; Nischt, R.; Mauch, C.
The disintegrin-like and cysteine-rich domains of ADAM-9 mediate interactions between melanoma cells and fibroblasts (2011), J. Biol. Chem., 286, 6801-6807.

Search for more literature for 3.4.24.B9

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell	ADAM-9 is expressed in human melanoma at the tumor-stroma border where direct or indirect interactions between tumor cells and fibroblasts occur	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ADAM-9	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	silencing of ADAM-9 in melanoma cells significantly reduces cell adhesion to fibroblasts. Ablation of ADAM-9 in fibroblasts almost completely abolishes these cellular interactions and melanoma cell invasion in vitro	Homo sapiens
physiological function	fibroblasts adhere to the adhesive domains of ADAM-9 in the presence of Mn2+ ions. ADAM-9 expression plays an important role in mediating cell-cell contacts between fibroblasts and melanoma cells. These interactions contribute to proteolytic activities required during invasion of melanoma cells	Homo sapiens

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Release 2023.1 (January 2023)