Literature summary for 3.4.24.B9 extracted from

Sung, S.; Kubo, H.; Shigemura, K.; Arnold, R.S.; Logani, S.; Wang, R.; Konaka, H.; Nakagawa, M.; Mousses, S.; Amin, M.; Anderson, C.; Johnstone, P.; Petros, J.A.; Marshall, F.F.; Zhau, H.E.; Chung, L.W.
Oxidative stress induces ADAM9 protein expression in human prostate cancer cells (2006), Cancer Res., 66, 9519-9526.

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Application

Application	Comment	Organism
medicine	elevated level of enzyme in malignant compared to benign prostate tissue. Increase in enzyme protein and mRNA upon exposure of prostate cells to stress conditions. Inhibition of stress-induction of enzyme by actinomycin D and cycloheximide. Decrease of enzyme expression results in apoptotic cell death in prostate cancer cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
LNCaP cell	prostate cancer cell, elevated level of enzyme during the transition of cells from androgen-dependent to androgen-independent and metastatic state. Induction of enzyme is abrogated by the antioxidant ebselen or the enzyme catalase	Homo sapiens	-
prostate gland	elevated level of enzyme in malignant compared to benign tissue. Increase in enzyme protein and mRNA upon exposure of prostate cells to stress conditions. Inhibition of stress-induction of enzyme by actinomycin D and cycloheximide	Homo sapiens	-

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Release 2023.1 (January 2023)