3.4.24.15: thimet oligopeptidase

This is an abbreviated version!
For detailed information about thimet oligopeptidase, go to the full flat file.

Word Map on EC 3.4.24.15

3.4.24.15

angiotensin

aminopeptidase

endothelial

angiotensin-converting

neuropeptides

metastasis

timp

mmp-9

metalloproteinase

neurotensin

carboxypeptidase

thrombospondin

chondrocytes

cartilage

osteoarthritis

endopeptidases

neurolysin

disintegrin

transwell

enkephalin

captopril

natriuretic

1,10-phenanthroline

phosphoramidon

zinc-dependent

dynorphins

aggrecan

bestatin

ace2

enkephalinase

adam17

hexxh

i-converting

gcpii

endothelin-converting

thiorphan

endopeptidase-24.11

lhrh

insulin-degrading

angiotensin-1-7

post-proline

adamts1

enkephalin-containing

medicine

Reaction

Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues =

Synonyms

BIE, bradykinin-inactivating endopeptidase, EC 3.4.22.19, EC 3.4.99.31, endo-oligopeptidase A, endooligopeptidase A, endopeptidase 24-15, endopeptidase 24.15, endopeptidase EC 3.4.24.15, EOPA, EP 24.15, EP24.15, MdpA, metallo-dipeptidase aeruginosa, metalloendopeptidase 24.15, metalloendopeptidase EC 3.4.24.15, metallopeptidase, More, MP78, neutral endopeptidase 24.15, PA4498, peptidase, thimet oligo-, Pz peptidase A, Pz peptidase B, Pz-peptidase, Pz-peptidase A, soluble metallo-endopeptidase, soluble metallopeptidase, thimet oligopeptidase, thimet peptidase, thimet-oligopeptidase, thiol-dependent metalloendopeptidase, THOP1, TOP, Top1, Top2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.15 thimet oligopeptidase

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Results	in table
16	Activating Compound
165	AA Sequence
1	Application
1	CAS Registry Number
26	Cloned(Commentary)
6	Crystallization (Commentary)
948	Disease/ Diagnostics
6	Expression
46	General Information
2	General Stability
20	IC50 Value
171	Inhibitors
20	kcat/KM [mM/s]
31	Ki Value [mM]
242	KM Value [mM]
60	Localization
39	Metals/Ions
17	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
296	Organism
2	Oxidation Stability
2	PDB ID
15	pH Optimum
5	pH Range
2	pH Stability
5	Posttranslational Modification
30	Protein Variants
20	Purification (Commentary)
1	Reaction
2	Reaction Type
89	Reference
1	Renatured (Commentary)
119	Source Tissue
12	Specific Activity [micromol/min/mg]
1	Storage Stability
417	Substrates and Products (Substrate)
21	Subunits
91	Synonyms
9	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
252	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 3.4.24.15 - thimet oligopeptidase

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Ca2+

4 entries

Cd2+

Gallus gallus

restores activity after EDTA treatment

Co2+

KCl

strong activation

Mn2+

restores activity after EDTA treatment

Na2SO4

strong activation

NaCl

strong activation

NaI

modest activation

NH4Cl

modest activation

Zinc

Zn2+

additional information

3 entries