3.4.24.15: thimet oligopeptidase

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For detailed information about thimet oligopeptidase, go to the full flat file.

Reaction

Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues =

Synonyms

BIE, bradykinin-inactivating endopeptidase, EC 3.4.22.19, EC 3.4.99.31, endo-oligopeptidase A, endooligopeptidase A, endopeptidase 24-15, endopeptidase 24.15, endopeptidase EC 3.4.24.15, EOPA, EP 24.15, EP24.15, MdpA, metallo-dipeptidase aeruginosa, metalloendopeptidase 24.15, metalloendopeptidase EC 3.4.24.15, metallopeptidase, More, MP78, neutral endopeptidase 24.15, PA4498, peptidase, thimet oligo-, Pz peptidase A, Pz peptidase B, Pz-peptidase, Pz-peptidase A, soluble metallo-endopeptidase, soluble metallopeptidase, thimet oligopeptidase, thimet peptidase, thimet-oligopeptidase, thiol-dependent metalloendopeptidase, THOP1, TOP, Top1, Top2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.15 thimet oligopeptidase

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Results	in table
16	Activating Compound
165	AA Sequence
1	Application
1	CAS Registry Number
26	Cloned(Commentary)
6	Crystallization (Commentary)
948	Disease/ Diagnostics
6	Expression
46	General Information
2	General Stability
20	IC50 Value
171	Inhibitors
20	kcat/KM [mM/s]
31	Ki Value [mM]
242	KM Value [mM]
60	Localization
39	Metals/Ions
17	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
296	Organism
2	Oxidation Stability
2	PDB ID
15	pH Optimum
5	pH Range
2	pH Stability
5	Posttranslational Modification
30	Protein Variants
20	Purification (Commentary)
1	Reaction
2	Reaction Type
89	Reference
1	Renatured (Commentary)
119	Source Tissue
12	Specific Activity [micromol/min/mg]
1	Storage Stability
417	Substrates and Products (Substrate)
21	Subunits
91	Synonyms
9	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
252	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.24.15 - thimet oligopeptidase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3.5

Bos taurus

-

irreversible inactivation at or below

37066

8

Rattus norvegicus

-

unstable above

37063