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3.4.24.15: thimet oligopeptidase

This is an abbreviated version!
For detailed information about thimet oligopeptidase, go to the full flat file.

Word Map on EC 3.4.24.15

Reaction

Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues =

Synonyms

BIE, bradykinin-inactivating endopeptidase, EC 3.4.22.19, EC 3.4.99.31, endo-oligopeptidase A, endooligopeptidase A, endopeptidase 24-15, endopeptidase 24.15, endopeptidase EC 3.4.24.15, EOPA, EP 24.15, EP24.15, MdpA, metallo-dipeptidase aeruginosa, metalloendopeptidase 24.15, metalloendopeptidase EC 3.4.24.15, metallopeptidase, More, MP78, neutral endopeptidase 24.15, PA4498, peptidase, thimet oligo-, Pz peptidase A, Pz peptidase B, Pz-peptidase, Pz-peptidase A, soluble metallo-endopeptidase, soluble metallopeptidase, thimet oligopeptidase, thimet peptidase, thimet-oligopeptidase, thiol-dependent metalloendopeptidase, THOP1, TOP, Top1, Top2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.15 thimet oligopeptidase

KI Value

KI Value on EC 3.4.24.15 - thimet oligopeptidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0004
(o-aminobenzoyl)-GFSIFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
pH 7.4, 37°C
0.014
(o-aminobenzoyl)-GFSPPRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
pH 7.4, 37°C
1.25
ADP
-
-
0.00429
angiotensin I
-
inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
0.00812
angiotensin II
-
inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
0.042
ATP
-
-
0.00536
bradykinin
-
inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
0.00009
CBZ-Phe-PSI[PO2CH2]-Ala-Lys-Ser
pH and temperature not specified in the publication
0.00004
dynorphin A1-13
-
inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
0.0000192 - 0.0000889
Gly-Pro-Phe-PSI[PO2CH2]-Gly-Pro-Nle
0.0063
L-phospho-Thr-Leu-Arg-Thr-Lys-Leu
-
pH 8.0, 37°C
0.0026
LTLRTKL
-
pH 8.0, 37°C
0.0008
LVVYPW-phenylThr-Gln-Arg-Tyr
-
pH 8.0, 37°C
0.0021 - 0.00256
LVVYPWTQRY
0.000023
N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-(alpha-aminoisobutyryl)-Tyr-p-aminobenzoate
-
-
0.0000142 - 0.0000298
N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-p-aminobenzoate
0.02776
PVNFKFLSH
-
inhibition of hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
0.0046
VVYPW-phenylThr-Gln-Arg-Tyr
-
pH 8.0, 37°C
0.0014 - 0.01002
VVYPWTQRY
0.0000378 - 0.0000901
Z-(D,L)-Phe-PSI[PO2CH2]-(D,L)-Ala-Lys-Ser
0.000043 - 0.0000877
Z-(D,L)-Phe-PSI[PO2CH2]-(D,L)-Ala-Lys-Tyr
additional information
additional information
-