3.4.24.15: thimet oligopeptidase

This is an abbreviated version!
For detailed information about thimet oligopeptidase, go to the full flat file.

Reaction

Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues =

Synonyms

BIE, bradykinin-inactivating endopeptidase, EC 3.4.22.19, EC 3.4.99.31, endo-oligopeptidase A, endooligopeptidase A, endopeptidase 24-15, endopeptidase 24.15, endopeptidase EC 3.4.24.15, EOPA, EP 24.15, EP24.15, MdpA, metallo-dipeptidase aeruginosa, metalloendopeptidase 24.15, metalloendopeptidase EC 3.4.24.15, metallopeptidase, More, MP78, neutral endopeptidase 24.15, PA4498, peptidase, thimet oligo-, Pz peptidase A, Pz peptidase B, Pz-peptidase, Pz-peptidase A, soluble metallo-endopeptidase, soluble metallopeptidase, thimet oligopeptidase, thimet peptidase, thimet-oligopeptidase, thiol-dependent metalloendopeptidase, THOP1, TOP, Top1, Top2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.15 thimet oligopeptidase

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Results	in table
16	Activating Compound
165	AA Sequence
1	Application
1	CAS Registry Number
26	Cloned(Commentary)
6	Crystallization (Commentary)
948	Disease/ Diagnostics
6	Expression
46	General Information
2	General Stability
20	IC50 Value
171	Inhibitors
20	kcat/KM [mM/s]
31	Ki Value [mM]
242	KM Value [mM]
60	Localization
39	Metals/Ions
17	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
296	Organism
2	Oxidation Stability
2	PDB ID
15	pH Optimum
5	pH Range
2	pH Stability
5	Posttranslational Modification
30	Protein Variants
20	Purification (Commentary)
1	Reaction
2	Reaction Type
89	Reference
1	Renatured (Commentary)
119	Source Tissue
12	Specific Activity [micromol/min/mg]
1	Storage Stability
417	Substrates and Products (Substrate)
21	Subunits
91	Synonyms
9	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
252	Turnover Number [1/s]

Expression

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Expression on EC 3.4.24.15 - thimet oligopeptidase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

cocaine treatment causes an increase in the ventral striatum in enzyme specific activity and enzyme relative mRNA amount determined by real time RT-PCR

2 entries

enzyme mRNA and protein are consistently up-regulated by shear stress, which can be completely prevented by pre-treatment of cells with either N-acetylcysteine, superoxide dismutase, or catalase, confirming ROS involvement

2 entries

expression and activity of thimet oligopeptidase are increased in the hippocampus of in rats during the acute phase of pilocarpine-induced epilepsy model

Rattus norvegicus

P24155

733751

expression and activity of thimet oligopeptidase are increased in the hippocampus of subjects with temporal lobe epilepsy

Homo sapiens

P52888

733751

cocaine treatment causes an increase in the ventral striatum in enzyme specific activity and enzyme relative mRNA amount determined by real time RT-PCR

Rattus norvegicus

P24155

733250

cocaine treatment causes an increase in the ventral striatum in enzyme specific activity and enzyme relative mRNA amount determined by real time RT-PCR

Rattus norvegicus Wistar

-

-

enzyme mRNA and protein are consistently up-regulated by shear stress, which can be completely prevented by pre-treatment of cells with either N-acetylcysteine, superoxide dismutase, or catalase, confirming ROS involvement

Homo sapiens

P52888

733616

enzyme mRNA and protein are consistently up-regulated by shear stress, which can be completely prevented by pre-treatment of cells with either N-acetylcysteine, superoxide dismutase, or catalase, confirming ROS involvement

Bos taurus

Q1JPJ8

733616