3.4.24.15: thimet oligopeptidase
This is an abbreviated version!
For detailed information about thimet oligopeptidase, go to the full flat file.
Word Map on EC 3.4.24.15
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3.4.24.15
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angiotensin
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aminopeptidase
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endothelial
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angiotensin-converting
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neuropeptides
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metastasis
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timp
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mmp-9
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metalloproteinase
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neurotensin
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carboxypeptidase
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thrombospondin
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chondrocytes
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cartilage
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osteoarthritis
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endopeptidases
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neurolysin
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disintegrin
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transwell
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enkephalin
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captopril
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natriuretic
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1,10-phenanthroline
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phosphoramidon
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zinc-dependent
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dynorphins
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aggrecan
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bestatin
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ace2
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enkephalinase
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adam17
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hexxh
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i-converting
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gcpii
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endothelin-converting
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thiorphan
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endopeptidase-24.11
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lhrh
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insulin-degrading
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angiotensin-1-7
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post-proline
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adamts1
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enkephalin-containing
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medicine
- 3.4.24.15
- angiotensin
- aminopeptidase
- endothelial
-
angiotensin-converting
- neuropeptides
- metastasis
- timp
- mmp-9
- metalloproteinase
- neurotensin
- carboxypeptidase
- thrombospondin
- chondrocytes
- cartilage
- osteoarthritis
- endopeptidases
- neurolysin
-
disintegrin
-
transwell
- enkephalin
- captopril
-
natriuretic
- 1,10-phenanthroline
- phosphoramidon
-
zinc-dependent
- dynorphins
- aggrecan
- bestatin
- ace2
- enkephalinase
- adam17
-
hexxh
-
i-converting
- gcpii
-
endothelin-converting
- thiorphan
- endopeptidase-24.11
- lhrh
-
insulin-degrading
-
angiotensin-1-7
-
post-proline
- adamts1
-
enkephalin-containing
- medicine
Reaction
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues =
Synonyms
BIE, bradykinin-inactivating endopeptidase, EC 3.4.22.19, EC 3.4.99.31, endo-oligopeptidase A, endooligopeptidase A, endopeptidase 24-15, endopeptidase 24.15, endopeptidase EC 3.4.24.15, EOPA, EP 24.15, EP24.15, MdpA, metallo-dipeptidase aeruginosa, metalloendopeptidase 24.15, metalloendopeptidase EC 3.4.24.15, metallopeptidase, More, MP78, neutral endopeptidase 24.15, PA4498, peptidase, thimet oligo-, Pz peptidase A, Pz peptidase B, Pz-peptidase, Pz-peptidase A, soluble metallo-endopeptidase, soluble metallopeptidase, thimet oligopeptidase, thimet peptidase, thimet-oligopeptidase, thiol-dependent metalloendopeptidase, THOP1, TOP, Top1, Top2
ECTree
3.4.24.15 thimet oligopeptidaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.24.15 - thimet oligopeptidase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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aortic endothelial cell culture. Enzyme is sensitive to Gialpha2/3 inhibition. Under cyclic strain conditions, level of secreted enzyme increases 2.6fold
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aortic endothelial cell culture. Enzyme is sensitive to Gialpha2/3 inhibition. Under cyclic strain conditions, level of secreted enzyme increases 2.6fold
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cultured trigeminal ganglia, similar expression profile of enzyme and type 2 bradykinin receptor
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longitudinal smooth muscle membranes and circular smooth muscle membranes
additional information
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median eminence and preoptic area in close proximity with LHRH cell bodies
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treated with pentylenentetrazol, an antagonist of GABAa receptor ion channel binding site. Significant decrease of enzyme activity and protein in the hippocampus after administration of pentylenentetrazol, pretreatment with MK-801 recovered the change of activity
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EP24.15 colocalizes with calmodulin in the cytosol of resting HEK293 cells
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the nuclear thimet oligopeptidase is coexpressed with estrogen receptor alpha in hypothalamic cells, and also in ventrolateral portion of the ventromedial hypothalamic nucleus and the midbrain central grey
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the nuclear thimet oligopeptidase is coexpressed with estrogen receptor alpha in hypothalamic cells, and also in ventrolateral portion of the ventromedial hypothalamic nucleus and the midbrain central grey
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additional information
enzyme expression analysis by quantitative real-time PCR
additional information
enzyme expression analysis by quantitative real-time PCR
additional information
the enzyme shows a broad tissue and subcellular compartment distribution
additional information
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during embryonic development, EP24.15 is localized in the same neuroanatomical regions as LHRH and LHRH-(1-5)
additional information
THOP1 is ubiquitously expressed in mammalian cells and tissues, and in rodents its specific activity is highest in brain, endocrine tissues, bone marrow and immune system
additional information
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THOP1 is ubiquitously expressed in mammalian cells and tissues, and in rodents its specific activity is highest in brain, endocrine tissues, bone marrow and immune system
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additional information
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presence of EP24.15 in the perivascular space of the median eminence and secretion into portal blood
